FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154745425> ?p ?o ?g. }

• W2154745425 endingPage "942" @default.
• W2154745425 startingPage "928" @default.
• W2154745425 abstract "Multiple pathways are involved in maintaining the genetic integrity of a cell after its exposure to ionizing radiation. Although repair mechanisms such as homologous recombination and nonhomologous end-joining are important mammalian responses to double-strand DNA damage, cell cycle regulation is perhaps the most important determinant of ionizing radiation sensitivity. A common cellular response to DNA-damaging agents is the activation of cell cycle checkpoints. The DNA damage induced by ionizing radiation initiates signals that can ultimately activate either temporary checkpoints that permit time for genetic repair or irreversible growth arrest that results in cell death (necrosis or apoptosis). Such checkpoint activation constitutes an integrated response that involves sensor (RAD, BRCA, NBS1), transducer (ATM, CHK), and effector (p53, p21, CDK) genes. One of the key proteins in the checkpoint pathways is the tumor suppressor gene p53, which coordinates DNA repair with cell cycle progression and apoptosis. Specifically, in addition to other mediators of the checkpoint response (CHK kinases, p21), p53 mediates the two major DNA damage-dependent cellular checkpoints, one at the G1–S transition and the other at the G2–M transition, although the influence on the former process is more direct and significant. The cell cycle phase also determines a cell's relative radiosensitivity, with cells being most radiosensitive in the G2-M phase, less sensitive in the G1 phase, and least sensitive during the latter part of the S phase. This understanding has, therefore, led to the realization that one way in which chemotherapy and fractionated radiotherapy may work better is by partial synchronization of cells in the most radiosensitive phase of the cell cycle. We describe how cell cycle and DNA damage checkpoint control relates to exposure to ionizing radiation." @default.
• W2154745425 created "2016-06-24" @default.
• W2154745425 creator A5016519845 @default.
• W2154745425 creator A5042960706 @default.
• W2154745425 date "2004-07-01" @default.
• W2154745425 modified "2023-10-18" @default.
• W2154745425 title "Role of cell cycle in mediating sensitivity to radiotherapy" @default.
• W2154745425 cites W1000864245 @default.
• W2154745425 cites W1541806623 @default.
• W2154745425 cites W1603239391 @default.
• W2154745425 cites W1604195255 @default.
• W2154745425 cites W1611268078 @default.
• W2154745425 cites W1618806168 @default.
• W2154745425 cites W1633875338 @default.
• W2154745425 cites W1657827244 @default.
• W2154745425 cites W1661087247 @default.
• W2154745425 cites W1725731812 @default.
• W2154745425 cites W178749539 @default.
• W2154745425 cites W1842375597 @default.
• W2154745425 cites W1850446337 @default.
• W2154745425 cites W1896635905 @default.
• W2154745425 cites W1964466129 @default.
• W2154745425 cites W1966647512 @default.
• W2154745425 cites W1966675362 @default.
• W2154745425 cites W1967006634 @default.
• W2154745425 cites W1967880683 @default.
• W2154745425 cites W1968423730 @default.
• W2154745425 cites W1970736880 @default.
• W2154745425 cites W1972376460 @default.
• W2154745425 cites W1972666371 @default.
• W2154745425 cites W1973501326 @default.
• W2154745425 cites W1973771911 @default.
• W2154745425 cites W1974010399 @default.
• W2154745425 cites W1975664090 @default.
• W2154745425 cites W1976146332 @default.
• W2154745425 cites W1978518304 @default.
• W2154745425 cites W1982061874 @default.
• W2154745425 cites W1984998883 @default.
• W2154745425 cites W1985840237 @default.
• W2154745425 cites W1986179131 @default.
• W2154745425 cites W1986965946 @default.
• W2154745425 cites W1987238939 @default.
• W2154745425 cites W1988309683 @default.
• W2154745425 cites W1988876917 @default.
• W2154745425 cites W1989936068 @default.
• W2154745425 cites W1990933519 @default.
• W2154745425 cites W1991494214 @default.
• W2154745425 cites W1991736202 @default.
• W2154745425 cites W1992389078 @default.
• W2154745425 cites W1996173407 @default.
• W2154745425 cites W1996237823 @default.
• W2154745425 cites W1996626174 @default.
• W2154745425 cites W1996930825 @default.
• W2154745425 cites W1997439972 @default.
• W2154745425 cites W2001797499 @default.
• W2154745425 cites W2002204846 @default.
• W2154745425 cites W2002503549 @default.
• W2154745425 cites W2004008931 @default.
• W2154745425 cites W2006550224 @default.
• W2154745425 cites W2009963985 @default.
• W2154745425 cites W2011994306 @default.
• W2154745425 cites W2012126331 @default.
• W2154745425 cites W2012764502 @default.
• W2154745425 cites W2013330927 @default.
• W2154745425 cites W2015807631 @default.
• W2154745425 cites W2017297714 @default.
• W2154745425 cites W2018685233 @default.
• W2154745425 cites W2018800110 @default.
• W2154745425 cites W2019519191 @default.
• W2154745425 cites W2019595393 @default.
• W2154745425 cites W2022811243 @default.
• W2154745425 cites W2023214683 @default.
• W2154745425 cites W2024544131 @default.
• W2154745425 cites W2027732005 @default.
• W2154745425 cites W2029248336 @default.
• W2154745425 cites W2033861133 @default.
• W2154745425 cites W2035560215 @default.
• W2154745425 cites W2036754489 @default.
• W2154745425 cites W2037538036 @default.
• W2154745425 cites W2038809726 @default.
• W2154745425 cites W2043262099 @default.
• W2154745425 cites W2044874191 @default.
• W2154745425 cites W2050686338 @default.
• W2154745425 cites W2051148606 @default.
• W2154745425 cites W2052129210 @default.
• W2154745425 cites W2052598236 @default.
• W2154745425 cites W2055078984 @default.
• W2154745425 cites W2056198230 @default.
• W2154745425 cites W2056236909 @default.
• W2154745425 cites W2056530510 @default.
• W2154745425 cites W2057949133 @default.
• W2154745425 cites W2057980517 @default.
• W2154745425 cites W2058583494 @default.
• W2154745425 cites W2058800908 @default.
• W2154745425 cites W2058850076 @default.
• W2154745425 cites W2059365987 @default.
• W2154745425 cites W2060054690 @default.
• W2154745425 cites W2061362720 @default.

• next