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• W2154751252 abstract "ABSTRACT Introduction With increasing interest and clinical research in male sexual disorders, it has become clear that not only psychological but also organic, neurobiological, and genetic factors may play an important role in premature ejaculation (PE). Aim This article provides an overview of the different treatment options both for lifelong (primary, “congenital”) and acquired (secondary) PE. Methods Review of the literature. Main Outcome Measures Currently used treatment options for PE. Results Treatments reviewed include psychological/behavioral/sexual counseling therapy, topical anesthetics, dapoxetine, and other selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and phosphodiesterase-5 (PDE-5) inhibitors. Conclusions Before starting any therapy for PE, correct diagnosis has to be made considering the patient's reported intravaginal ejaculatory latency time (IELT) and the duration and type of PE. Concomitant erectile dysfunction (ED) should be either ruled out or proven by appropriate means. In uncomplicated cases of PE with stable partnerships, medical treatment represents the first-choice option with a high likelihood of success. Dapoxetine, where available, or other SSRIs provide suitable therapeutic options with a good risk/benefit profile for patients. In complicated (“difficult-to-treat”) PE patients, a combination of medication and sexual counseling should be considered the first treatment option. Combination therapies of PDE-5 inhibitors and PE-related medications should be offered to patients suffering from comorbid PE and ED, with ED treatment starting first. In those patients with severe PE—IELTs of &lt;30–60 seconds or anteportal ejaculation—combination therapy of topical and oral medications can be offered and may considerably increase IELT, compared with either monotherapy." @default.
• W2154751252 created "2016-06-24" @default.
• W2154751252 creator A5088486376 @default.
• W2154751252 date "2011-10-01" @default.
• W2154751252 modified "2023-10-01" @default.
• W2154751252 title "An Overview of Pharmacotherapy in Premature Ejaculation" @default.
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• W2154751252 doi "https://doi.org/10.1111/j.1743-6109.2011.02451.x" @default.
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