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- W2154752949 abstract "BACKGROUND: The restricted expression of ADAMTS-5 (A Disintegrin And Metalloproteinase with ThromboSpondin repeats-5) to the maternal–fetal interface in mice has led to this novel metalloproteinase being assigned the trivial name ‘implantin’. METHODS: As a first step in determining whether ADAMTS-5 also contributes to the implantation process in humans, we have examined the spatiotemporal expression of this ADAMTS subtype in the endometrium during the menstrual cycle and pregnancy by immunohistochemical analysis. A quantitative competitive PCR (QC-PCR) strategy and western blotting were subsequently used to determine whether interleukin (IL)-1β and transforming growth factor (TGF)-β1, two cytokines involved in the formation of the maternal–fetal interface, were capable of regulating ADAMTS-5 messenger RNA (mRNA) and protein levels in primary cultures of stromal cells isolated from first trimester decidual tissues. RESULTS: ADAMTS-5 expression in the stroma of the human endometrium correlates with decidualization of this cellular compartment in vivo. IL-1β was found to increase (P < 0.05) whereas TGF-β1 decreased (P < 0.05) ADAMTS-5 mRNA and protein levels in decidual stromal cell cultures in a concentration- and time-dependent manner. These regulatory effects were attenuated by function-perturbing antibodies directed against either cytokine. CONCLUSIONS: ADAMTS-5 expression is restricted to decidualized stromal cells of the human endometrium in vivo and is subject to regulation by cytokines in vitro." @default.
- W2154752949 created "2016-06-24" @default.
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- W2154752949 date "2006-10-26" @default.
- W2154752949 modified "2023-09-24" @default.
- W2154752949 title "Expression of ADAMTS-5/implantin in human decidual stromal cells: regulatory effects of cytokines" @default.
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- W2154752949 doi "https://doi.org/10.1093/humrep/del356" @default.
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