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- W2154802933 abstract "Summary Calcium channel blockers are increasingly used in the treatment of hypertension. Newer calcium channel blockers of the dihydropyridine group have longer elimination half-lives (t½) that permit once-daily dosage and are generally better tolerated than their parent compound. In this study, the efficacy and safety of lacidipine and amlodipine were compared in 65 patients with mild-to-moderate hypertension attending the hypertension outpatient clinic of a teaching hospital in a randomized double-blind cross-over trial with dose titration. Lacidipine and amlodipine both significantly reduced systolic blood pressure (SBP: by 19.2 ± 13.5 and 22.3 ± 15.3 mm Hg, respectively) and diastolic BP (DBP: 13.3 ± 4.2 and 12.3 ± 5.3 mm Hg, respectively) 24 h postdose. There were no significant differences in their antihypertensive effects. The incidence of adverse events (AE) was 3% for lacidipine and 8% for amlodipine. The incidence of withdrawal from the study due to side effects was 0% for lacidipine and 3% for amlodipine. These results suggest that lacidipine is well-tolerated, and is as effective as amlodipine as a once-daily antihypertensive agent." @default.
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- W2154802933 title "Relative Efficacy and Tolerability of Lacidipine and Amlodipine in Patients with Mild-to-Moderate Hypertension: A Randomized Double-Blind Study" @default.
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- W2154802933 doi "https://doi.org/10.1097/00005344-199608000-00021" @default.
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