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• W2154807162 abstract "Necrotic enteritis (NE) is one of the most important enteric diseases in poultry and is a high cost to the industry worldwide. It is caused by avian-specific, Necrotic Enteritis Beta toxin (NetB)-producing, strains of Clostridium perfringens that also possess in common other virulence-associated genes. In Europe the disease incidence has increased since the ban on in-feed growth promoting antibiotics. Because of this, many recent studies of NE have focused on finding different ways to control the disease, and on understanding its pathogenesis. Frustratingly, reproduction of the disease has proven impossible for some researchers. This review describes and discusses factors known to be important in reproducing the disease experimentally, as well as other considerations in reproducing the disease. The critical bacterial factor is the use of virulent, netB-positive, strains; virulence can be enhanced by using tpeL- positive strains and by the use of young rather than old broth cultures to increase toxin expression. Intestinal damaging factors, notably the use of concurrent or preceding coccidial infection, or administration of coccidial vaccines, combined with netB-positive C. perfringens administration, can also be used to induce NE. Nutritional factors, particularly feeding high percentage of cereals containing non-starch polysaccharides (NSP) (wheat, rye, and barley) enhance disease by increasing digesta viscosity, mucus production and bacterial growth. Animal proteins, especially fish meal, enhance C. perfringens proliferation and toxin production. Other factors are discussed that may affect outcome but for which evidence of their importance is lacking. The review compares the different challenge approaches; depending on the aim of particular studies, the different critical factors can be adjusted to affect the severity of the lesions induced. A standardized scoring system is proposed for international adoption based on gross rather than histopathological lesions; if universally adopted this will allow better comparison between studies done by different researchers. Also a scoring system is provided to assist decisions on humane euthanasia of sick birds." @default.
• W2154807162 created "2016-06-24" @default.
• W2154807162 creator A5032601612 @default.
• W2154807162 creator A5050534187 @default.
• W2154807162 creator A5089447139 @default.
• W2154807162 date "2012-10-26" @default.
• W2154807162 modified "2023-10-02" @default.
• W2154807162 title "The successful experimental induction of necrotic enteritis in chickens by Clostridium perfringens: a critical review" @default.
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• W2154807162 doi "https://doi.org/10.1186/1297-9716-43-74" @default.
• W2154807162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3546943" @default.
• W2154807162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23101966" @default.
• W2154807162 hasPublicationYear "2012" @default.
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