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- W2154827297 abstract "Inflammatory cells and inflammatory mediators are crucially involved in the genesis, persistence and severity of pain following trauma, infection or nerve injury. The mechanisms and pathways mediating pain and nociception are transcriptionally regulated. The transcriptional mediator nuclear factor (NF)-κB plays a major role in regulating the inflammatory milieu, ostensibly via the control of gene expression/suppression. An association has recently emerged to establish a possible link between NF-κB and pain/nociception, purportedly through the regulation of the inflammatory loop and the secretion (biosynthesis) of pro-inflammatory mediators. Current concepts conspicuously indicate that the effective inhibition of this transcription factor and associated upstream kinase(s) and the pathways that regulate its nuclear translocation could be major targets in a new strategy for the alleviation of inflammation and inflammatory-related pain. To better understand this relationship between NFκB and the evolution of pain and hyperalgesia/nociception, it is imperative to unravel the molecular basis of this process. This survey definitively integrates current themes pertaining to the pivotal role that NF-κB shares in regulating pain through the decoding of implicated molecular pathways and signaling mechanisms." @default.
- W2154827297 created "2016-06-24" @default.
- W2154827297 creator A5077600804 @default.
- W2154827297 date "2007-01-01" @default.
- W2154827297 modified "2023-09-27" @default.
- W2154827297 title "Review article: Molecular Regulation of Inflammatory Pain and Hyperalgesia - Is NF-κB the Lynchpin? Focus Article and Critical Review" @default.
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