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• W2154837340 abstract "Background: Accurate assessment of hydration status and specification of dry weight (DW) are major problems in the clinical treatment of hemodialysis (HD) patients. Bioelectrical impedance analysis (BIA) has been recognized as a noninvasive and simple technique for the determination of DW in HD patients. Design, setting, participants, and measurements: This study was designed to develop and validate BIA prediction equations for DW in HD patients. It included white adults (1540 disease-free adults with normal body mass index [BMI] and 456 prevalent and 27 incident HD patients). All participants underwent at least one single-frequency BIA measurement (800 μA and 50 kHz alternating sinusoidal current with a standard tetrapolar technique). The BIA variable measured was resistance (R). Data of 1463 (95% of the cohort) disease-free individuals with normal BMI (prediction sample) were used to establish best-fitting BIA prediction equations of body weight. The latter were cross-validated in the residual 5% subset (77 individuals) of the same cohort (validation sample). Results: Multiple regression analysis showed a significant relationship among body weight, R, age, and height in 739 men (<i>R</i>² = 0.82, <i>P</i> < 0.0001) and among body weight, R, and height in 724 women (<i>R</i>² = 0.68, <i>P</i> < 0.0001) in the prediction sample. The Bland Altman analysis showed a mean difference between predicted and measured body weight of 0.3 ± 1.0 kg (95% confidence interval ± 2.0 kg) in the validation sample. The BIA prediction equations that were obtained in disease-free individuals with normal BMI were applied to a cohort of 456 prevalent HD patients: The mean difference between achieved and estimated DW was 0.1 ± 1.0 kg (<i>P</i> = 0.53) in men and −0.3 ± 1.0 (<i>P</i> = 0.76) in women. Finally, BIA prediction equations were tested in a cohort of 27 incident HD patients. The mean difference between predicted and achieved DW was −0.6 ± 1.0 kg (<i>P</i> = 0.76) in men and 0.6 ± 1.0 (<i>P</i> = 0.50) in women. Conclusions: This study was able to develop and validate BIA prediction equations for DW in HD patients. They seem to be a promising tool; however, they still need external validation." @default.
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• W2154837340 date "2007-07-01" @default.
• W2154837340 modified "2023-09-26" @default.
• W2154837340 title "Development and Validation of Bioimpedance Analysis Prediction Equations for Dry Weight in Hemodialysis Patients" @default.
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• W2154837340 doi "https://doi.org/10.2215/cjn.00240107" @default.
• W2154837340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17699481" @default.
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