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- W2154841339 abstract "It is unclear that how subcellular organelles respond to external mechanical stimuli. Here, we investigated the molecular mechanisms by which mechanical force regulates Ca(2+) signaling at endoplasmic reticulum (ER) in human mesenchymal stem cells. Without extracellular Ca(2+), ER Ca(2+) release is the source of intracellular Ca(2+) oscillations induced by laser-tweezer-traction at the plasma membrane, providing a model to study how mechanical stimuli can be transmitted deep inside the cell body. This ER Ca(2+) release upon mechanical stimulation is mediated not only by the mechanical support of cytoskeleton and actomyosin contractility, but also by mechanosensitive Ca(2+) permeable channels on the plasma membrane, specifically TRPM7. However, Ca(2+) influx at the plasma membrane via mechanosensitive Ca(2+) permeable channels is only mediated by the passive cytoskeletal structure but not active actomyosin contractility. Thus, active actomyosin contractility is essential for the response of ER to the external mechanical stimuli, distinct from the mechanical regulation at the plasma membrane." @default.
- W2154841339 created "2016-06-24" @default.
- W2154841339 creator A5013851036 @default.
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- W2154841339 date "2015-02-10" @default.
- W2154841339 modified "2023-10-18" @default.
- W2154841339 title "Distinct mechanisms regulating mechanical force-induced Ca2+ signals at the plasma membrane and the ER in human MSCs" @default.
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- W2154841339 doi "https://doi.org/10.7554/elife.04876" @default.
- W2154841339 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4337650" @default.
- W2154841339 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25667984" @default.
- W2154841339 hasPublicationYear "2015" @default.
- W2154841339 type Work @default.