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- W2154853658 abstract "Abstract Summary: Standard transcriptomics measures total cellular RNA levels. Our understanding of gene regulation would be greatly improved if we could measure RNA synthesis and decay rates on a genome-wide level. To that end, the Dynamic Transcriptome Analysis (DTA) method has been developed. DTA combines metabolic RNA labeling with standard transcriptomics to measure RNA synthesis and decay rates in a precise and non-perturbing manner. Here, we present the open source R/Bioconductor software package DTA. It implements all required bioinformatics steps that allow the accurate absolute quantification and comparison of RNA turnover. Availability: DTA is part of R/Bioconductor. To download and install DTA refer to http://bioconductor.org/packages/2.10/bioc/html/DTA.html Contact: schwalb@lmb.uni-muenchen.de" @default.
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- W2154853658 date "2012-01-28" @default.
- W2154853658 modified "2023-09-27" @default.
- W2154853658 title "Measurement of genome-wide RNA synthesis and decay rates with Dynamic Transcriptome Analysis (DTA)" @default.
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- W2154853658 doi "https://doi.org/10.1093/bioinformatics/bts052" @default.
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