FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154861470> ?p ?o ?g. }

• W2154861470 endingPage "6066" @default.
• W2154861470 startingPage "6061" @default.
• W2154861470 abstract "One of the difficulties in preparing accurate ambient-temperature model complexes for heme proteins, particularly in the ferric state, has been the generation of mixed-ligand adducts: complexes with different ligands on either side of the heme. The difference in the accessibility of the two sides of the heme in the H93G cavity mutant of myoglobin (Mb) provides a potential general solution to this problem. To demonstrate the versatility of H93G Mb for the preparation of heme protein models, numerous mixed-ligand adducts of ferrous, ferric, and ferryl imidazole-ligated H93G (H93G(Im) Mb) have been prepared. The complexes have been characterized by electronic absorption and magnetic circular dichroism (MCD) spectroscopy in comparison to analogous derivatives of wild type Mb. The starting ferric H93G(Im) Mb state spectroscopically resembles wild-type ferric Mb as expected for a complex containing a single imidazole in the proximal cavity and water bound on the distal side. Addition of a sixth ligand to ferric H93G(Im) Mb, whether charge neutral (imidazole) or anionic (cyanide and azide), results in formation of six-coordinate low-spin complexes with MCD characteristics similar to those of parallel derivatives of wild-type ferric Mb. Reduction of ferric H93G(Im) Mb and subsequent exposure to either CO, NO, or O2 produces ferrous complexes (deoxy, CO, NO, and O2) that consistently exhibit MCD spectra similar to the analogous ferrous species of wild-type ferrous Mb. Most interestingly, reaction of ferric H93G(Im) Mb with H2O2 results in the formation of a stable high-valent oxoferryl complex with MCD characteristics that are essentially identical to those of oxoferryl wild-type Mb. The generation of such a wide array of mixed-ligand heme complexes demonstrates the efficacy of the H93G Mb cavity mutant as a template for the preparation of heme protein model complexes." @default.
• W2154861470 created "2016-06-24" @default.
• W2154861470 creator A5002133506 @default.
• W2154861470 creator A5004026957 @default.
• W2154861470 creator A5007451401 @default.
• W2154861470 creator A5022812536 @default.
• W2154861470 creator A5038193276 @default.
• W2154861470 date "2000-12-01" @default.
• W2154861470 modified "2023-10-14" @default.
• W2154861470 title "The H93G Myoglobin Cavity Mutant as a Versatile Template for Modeling Heme Proteins: Ferrous, Ferric, and Ferryl Mixed-Ligand Complexes with Imidazole in the Cavity" @default.
• W2154861470 cites W1514532383 @default.
• W2154861470 cites W1565691495 @default.
• W2154861470 cites W1581948411 @default.
• W2154861470 cites W190145276 @default.
• W2154861470 cites W1964075597 @default.
• W2154861470 cites W1970198664 @default.
• W2154861470 cites W1971879307 @default.
• W2154861470 cites W1976141240 @default.
• W2154861470 cites W1977587847 @default.
• W2154861470 cites W1980802869 @default.
• W2154861470 cites W1982602226 @default.
• W2154861470 cites W1999778330 @default.
• W2154861470 cites W2006289163 @default.
• W2154861470 cites W2006601093 @default.
• W2154861470 cites W2016289343 @default.
• W2154861470 cites W2017551234 @default.
• W2154861470 cites W2027918904 @default.
• W2154861470 cites W2029672598 @default.
• W2154861470 cites W2038292842 @default.
• W2154861470 cites W2044705084 @default.
• W2154861470 cites W2046824288 @default.
• W2154861470 cites W2048459982 @default.
• W2154861470 cites W2070922600 @default.
• W2154861470 cites W2075333740 @default.
• W2154861470 cites W2075766195 @default.
• W2154861470 cites W2086172313 @default.
• W2154861470 cites W2095873332 @default.
• W2154861470 cites W2179092050 @default.
• W2154861470 cites W995921749 @default.
• W2154861470 doi "https://doi.org/10.1021/ic0007198" @default.
• W2154861470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11151505" @default.
• W2154861470 hasPublicationYear "2000" @default.
• W2154861470 type Work @default.
• W2154861470 sameAs 2154861470 @default.
• W2154861470 citedByCount "41" @default.
• W2154861470 countsByYear W21548614702012 @default.
• W2154861470 countsByYear W21548614702013 @default.
• W2154861470 countsByYear W21548614702014 @default.
• W2154861470 countsByYear W21548614702015 @default.
• W2154861470 countsByYear W21548614702018 @default.
• W2154861470 countsByYear W21548614702019 @default.
• W2154861470 countsByYear W21548614702020 @default.
• W2154861470 crossrefType "journal-article" @default.
• W2154861470 hasAuthorship W2154861470A5002133506 @default.
• W2154861470 hasAuthorship W2154861470A5004026957 @default.
• W2154861470 hasAuthorship W2154861470A5007451401 @default.
• W2154861470 hasAuthorship W2154861470A5022812536 @default.
• W2154861470 hasAuthorship W2154861470A5038193276 @default.
• W2154861470 hasConcept C108204754 @default.
• W2154861470 hasConcept C116569031 @default.
• W2154861470 hasConcept C121332964 @default.
• W2154861470 hasConcept C1276947 @default.
• W2154861470 hasConcept C170493617 @default.
• W2154861470 hasConcept C178790620 @default.
• W2154861470 hasConcept C179104552 @default.
• W2154861470 hasConcept C181199279 @default.
• W2154861470 hasConcept C185592680 @default.
• W2154861470 hasConcept C20705724 @default.
• W2154861470 hasConcept C2775832776 @default.
• W2154861470 hasConcept C2776217839 @default.
• W2154861470 hasConcept C2777723881 @default.
• W2154861470 hasConcept C2778063876 @default.
• W2154861470 hasConcept C2780534640 @default.
• W2154861470 hasConcept C2780874372 @default.
• W2154861470 hasConcept C4839761 @default.
• W2154861470 hasConcept C55493867 @default.
• W2154861470 hasConcept C68563686 @default.
• W2154861470 hasConcept C71240020 @default.
• W2154861470 hasConcept C75473681 @default.
• W2154861470 hasConcept C8010536 @default.
• W2154861470 hasConceptScore W2154861470C108204754 @default.
• W2154861470 hasConceptScore W2154861470C116569031 @default.
• W2154861470 hasConceptScore W2154861470C121332964 @default.
• W2154861470 hasConceptScore W2154861470C1276947 @default.
• W2154861470 hasConceptScore W2154861470C170493617 @default.
• W2154861470 hasConceptScore W2154861470C178790620 @default.
• W2154861470 hasConceptScore W2154861470C179104552 @default.
• W2154861470 hasConceptScore W2154861470C181199279 @default.
• W2154861470 hasConceptScore W2154861470C185592680 @default.
• W2154861470 hasConceptScore W2154861470C20705724 @default.
• W2154861470 hasConceptScore W2154861470C2775832776 @default.
• W2154861470 hasConceptScore W2154861470C2776217839 @default.
• W2154861470 hasConceptScore W2154861470C2777723881 @default.
• W2154861470 hasConceptScore W2154861470C2778063876 @default.
• W2154861470 hasConceptScore W2154861470C2780534640 @default.
• W2154861470 hasConceptScore W2154861470C2780874372 @default.
• W2154861470 hasConceptScore W2154861470C4839761 @default.
• W2154861470 hasConceptScore W2154861470C55493867 @default.

• next