FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154862144> ?p ?o ?g. }

• W2154862144 endingPage "756" @default.
• W2154862144 startingPage "752" @default.
• W2154862144 abstract "Aim: Diabetic dyslipidaemia, characterized by hypertriglyceridaemia as a result of elevated serum very-low-density lipoprotein (VLDL) concentrations, contributes to the increased risk of cardiovascular disease (CVD) in type 2 diabetes (T2DM). Proprotein convertase subtilisin/kexin type 9 (PCSK9) may play a role in regulating VLDL metabolism. We investigated the effect of fenofibrate on serum PCSK9 and VLDL particle concentrations in T2DM patients already receiving statin therapy. Methods: In a double-blind randomized crossover study, 15 statin-treated T2DM patients (63 ± 8 years, body mass index (BMI) 29 ± 3 kg/m2) were treated with fenofibrate (145 mg/day) or matching placebo for 12 weeks. Serum PCSK9 concentrations were measured by immunoassay. VLDL particle concentration and size were determined by nuclear magnetic resonance spectroscopy. Results: Fenofibrate decreased serum triglycerides (−23%), VLDL-triglycerides (−51%), total cholesterol (−11%), LDL-cholesterol (−16%), apolipoprotein B-100 (−16%), apolipoprotein C-III (−20%) and PCSK9 (−13%) concentrations compared with placebo (p < 0.05). Fenofibrate also decreased serum concentrations of large (−45%), medium (−66%) and small VLDL (−67%) particles (p < 0.05), without altering VLDL particle size. Serum PCSK9 reduction correlated with decreases in total (r = 0.526, p = 0.044) and small (r = 0.629, p = 0.021) VLDL particle concentrations. Conclusions: Fenofibrate concomitantly decreased serum PCSK9 and VLDL particle concentrations in statin-treated T2DM patients. These findings support a mechanistic link between PCSK9 and VLDL metabolism, possibly through an effect of PSK9 on VLDL receptor degradation." @default.
• W2154862144 created "2016-06-24" @default.
• W2154862144 creator A5000971455 @default.
• W2154862144 creator A5008118241 @default.
• W2154862144 creator A5008958109 @default.
• W2154862144 creator A5028698700 @default.
• W2154862144 creator A5070558504 @default.
• W2154862144 creator A5073990841 @default.
• W2154862144 creator A5079564889 @default.
• W2154862144 date "2010-03-26" @default.
• W2154862144 modified "2023-10-07" @default.
• W2154862144 title "Fenofibrate concomitantly decreases serum proprotein convertase subtilisin/kexin type 9 and very-low-density lipoprotein particle concentrations in statin-treated type 2 diabetic patients" @default.
• W2154862144 cites W1502524639 @default.
• W2154862144 cites W1966941449 @default.
• W2154862144 cites W1976691226 @default.
• W2154862144 cites W2003461527 @default.
• W2154862144 cites W2013982259 @default.
• W2154862144 cites W2016657679 @default.
• W2154862144 cites W2019173226 @default.
• W2154862144 cites W2020659754 @default.
• W2154862144 cites W2035099895 @default.
• W2154862144 cites W2040612932 @default.
• W2154862144 cites W2045995934 @default.
• W2154862144 cites W2054851194 @default.
• W2154862144 cites W2056411372 @default.
• W2154862144 cites W2067539811 @default.
• W2154862144 cites W2069993714 @default.
• W2154862144 cites W2073683795 @default.
• W2154862144 cites W2087956853 @default.
• W2154862144 cites W2106759269 @default.
• W2154862144 cites W2107513378 @default.
• W2154862144 cites W2107818754 @default.
• W2154862144 cites W2110083155 @default.
• W2154862144 cites W2119087485 @default.
• W2154862144 cites W2119708151 @default.
• W2154862144 cites W2125528229 @default.
• W2154862144 cites W2129950813 @default.
• W2154862144 cites W2130120054 @default.
• W2154862144 cites W2160761735 @default.
• W2154862144 cites W2167351741 @default.
• W2154862144 cites W2318873649 @default.
• W2154862144 doi "https://doi.org/10.1111/j.1463-1326.2010.01229.x" @default.
• W2154862144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20649626" @default.
• W2154862144 hasPublicationYear "2010" @default.
• W2154862144 type Work @default.
• W2154862144 sameAs 2154862144 @default.
• W2154862144 citedByCount "33" @default.
• W2154862144 countsByYear W21548621442012 @default.
• W2154862144 countsByYear W21548621442013 @default.
• W2154862144 countsByYear W21548621442014 @default.
• W2154862144 countsByYear W21548621442015 @default.
• W2154862144 countsByYear W21548621442016 @default.
• W2154862144 countsByYear W21548621442017 @default.
• W2154862144 countsByYear W21548621442018 @default.
• W2154862144 countsByYear W21548621442019 @default.
• W2154862144 countsByYear W21548621442022 @default.
• W2154862144 crossrefType "journal-article" @default.
• W2154862144 hasAuthorship W2154862144A5000971455 @default.
• W2154862144 hasAuthorship W2154862144A5008118241 @default.
• W2154862144 hasAuthorship W2154862144A5008958109 @default.
• W2154862144 hasAuthorship W2154862144A5028698700 @default.
• W2154862144 hasAuthorship W2154862144A5070558504 @default.
• W2154862144 hasAuthorship W2154862144A5073990841 @default.
• W2154862144 hasAuthorship W2154862144A5079564889 @default.
• W2154862144 hasConcept C126322002 @default.
• W2154862144 hasConcept C134018914 @default.
• W2154862144 hasConcept C185592680 @default.
• W2154862144 hasConcept C2778110834 @default.
• W2154862144 hasConcept C2778163477 @default.
• W2154862144 hasConcept C2778849439 @default.
• W2154862144 hasConcept C2780072125 @default.
• W2154862144 hasConcept C2780948078 @default.
• W2154862144 hasConcept C2911022245 @default.
• W2154862144 hasConcept C43554185 @default.
• W2154862144 hasConcept C62746215 @default.
• W2154862144 hasConcept C71924100 @default.
• W2154862144 hasConcept C8243546 @default.
• W2154862144 hasConceptScore W2154862144C126322002 @default.
• W2154862144 hasConceptScore W2154862144C134018914 @default.
• W2154862144 hasConceptScore W2154862144C185592680 @default.
• W2154862144 hasConceptScore W2154862144C2778110834 @default.
• W2154862144 hasConceptScore W2154862144C2778163477 @default.
• W2154862144 hasConceptScore W2154862144C2778849439 @default.
• W2154862144 hasConceptScore W2154862144C2780072125 @default.
• W2154862144 hasConceptScore W2154862144C2780948078 @default.
• W2154862144 hasConceptScore W2154862144C2911022245 @default.
• W2154862144 hasConceptScore W2154862144C43554185 @default.
• W2154862144 hasConceptScore W2154862144C62746215 @default.
• W2154862144 hasConceptScore W2154862144C71924100 @default.
• W2154862144 hasConceptScore W2154862144C8243546 @default.
• W2154862144 hasIssue "9" @default.
• W2154862144 hasLocation W21548621441 @default.
• W2154862144 hasLocation W21548621442 @default.
• W2154862144 hasOpenAccess W2154862144 @default.
• W2154862144 hasPrimaryLocation W21548621441 @default.
• W2154862144 hasRelatedWork W2040081726 @default.
• W2154862144 hasRelatedWork W2125528229 @default.
• W2154862144 hasRelatedWork W2138544596 @default.

• next