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• W2154872911 abstract "Background Differences in circulating steroid hormone levels have been hypothesized to explain ethnic differences in steroid-related diseases. The aim of this study was to determine the serum levels of a wide panel of steroid hormones, both androgens and estrogens, in healthy middle-aged African–Caribbean and European men. Design and methods Serum steroid hormone levels were determined in men participating in a systematic public health study funded by the French National Health Insurance system. Blood was collected in the morning from 304 healthy African–Caribbean and European men aged between 40 and 69 years. Serum steroids were measured by mass spectrometry–gas chromatography, except for DHEAS and sex hormone-binding globulin, which were determined by RIA. Data were analyzed in 10-year age intervals by analysis of covariance, with adjustment for age, body mass index, waist-to-hip ratio, tobacco and alcohol consumption, and season of sampling. Results Compared with Europeans, African–Caribbean men presented significantly higher serum levels of measured bioavailable testosterone, 4-androstenedione (4-dione), and estrone (E1) regardless of the age group, of 5-androstenediol (5-diol) in those aged 40–49 and 50–59 years, and of testosterone (TT) and dihydrotestosterone in those aged 40–49 years. In contrast, European men aged 40–69 years showed significantly higher serum levels of DHEA and DHEAS. Conclusions Significant differences in serum steroid hormone levels were observed in middle-aged African–Caribbean and European men. Whether such differences could contribute to ethnic differences in disease risk in adult men remains to be investigated. Some steroids, such as bioavailable TT, 4-dione, 5-diol, and E1, deserve particular attention." @default.
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• W2154872911 date "2011-12-01" @default.
• W2154872911 modified "2023-10-14" @default.
• W2154872911 title "Serum sex steroids measured in middle-aged European and African–Caribbean men by gas chromatography–mass spectrometry" @default.
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• W2154872911 doi "https://doi.org/10.1530/eje-11-0551" @default.
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