Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154874694> ?p ?o ?g. }
- W2154874694 endingPage "5345" @default.
- W2154874694 startingPage "5338" @default.
- W2154874694 abstract "Abstract The development of T cell tolerance directed toward tumor-associated Ags can limit the repertoire of functional tumor-reactive T cells, thus impairing the ability of vaccines to elicit effective antitumor immunity. Adoptive immunotherapy strategies using ex vivo expanded tumor-reactive effector T cells can bypass this problem; however, the susceptibility of effector T cells to undergoing tolerization suggests that tolerance might also negatively impact adoptive immunotherapy. Nonetheless, adoptive immunotherapy strategies can be effective, particularly those utilizing the drug cyclophosphamide (CY) and/or exogenous IL-2. In the current study, we used a TCR-transgenic mouse adoptive transfer system to assess whether CY plus IL-2 treatment rescues effector CD4 cell function in the face of tolerizing Ag (i.e., cognate parenchymal self-Ag). CY plus IL-2 treatment not only enhances proliferation and accumulation of effector CD4 cells, but also preserves the ability of these cells to express the effector cytokine IFN-γ (and to a lesser extent TNF-α) in proportion to the level of parenchymal self-Ag expression. When administered individually, CY but not IL-2 can markedly impede tolerization, although their combination is the most effective. Although effector CD4 cells in CY plus IL-2-treated self-Ag-expressing mice eventually succumb to tolerization, this delay results in an increased level of in situ IFN-γ expression in cognate Ag-expressing parenchymal tissues as well as death via a mechanism that requires direct parenchymal Ag presentation. These results suggest that one potential mechanism by which CY and IL-2 augment adoptive immunotherapy strategies to treat cancer is by impeding the tolerization of tumor-reactive effector T cells." @default.
- W2154874694 created "2016-06-24" @default.
- W2154874694 creator A5013574133 @default.
- W2154874694 creator A5018380983 @default.
- W2154874694 creator A5019064202 @default.
- W2154874694 creator A5021846790 @default.
- W2154874694 creator A5068533682 @default.
- W2154874694 creator A5068712106 @default.
- W2154874694 creator A5082915839 @default.
- W2154874694 date "2004-05-01" @default.
- W2154874694 modified "2023-09-24" @default.
- W2154874694 title "In Vivo Cyclophosphamide and IL-2 Treatment Impedes Self-Antigen-Induced Effector CD4 Cell Tolerization: Implications for Adoptive Immunotherapy" @default.
- W2154874694 cites W1524005671 @default.
- W2154874694 cites W1565072359 @default.
- W2154874694 cites W1571861420 @default.
- W2154874694 cites W1601858453 @default.
- W2154874694 cites W1610017743 @default.
- W2154874694 cites W1621615533 @default.
- W2154874694 cites W1633486542 @default.
- W2154874694 cites W1667620412 @default.
- W2154874694 cites W1763148533 @default.
- W2154874694 cites W1946555177 @default.
- W2154874694 cites W1976823049 @default.
- W2154874694 cites W1977298268 @default.
- W2154874694 cites W1982806739 @default.
- W2154874694 cites W1984781939 @default.
- W2154874694 cites W1987589866 @default.
- W2154874694 cites W1995201985 @default.
- W2154874694 cites W2002737769 @default.
- W2154874694 cites W2007533548 @default.
- W2154874694 cites W2016525911 @default.
- W2154874694 cites W2016671320 @default.
- W2154874694 cites W2018027744 @default.
- W2154874694 cites W2021171466 @default.
- W2154874694 cites W2030562643 @default.
- W2154874694 cites W2032582850 @default.
- W2154874694 cites W2035090794 @default.
- W2154874694 cites W2041808941 @default.
- W2154874694 cites W2046749316 @default.
- W2154874694 cites W2046965561 @default.
- W2154874694 cites W2047203592 @default.
- W2154874694 cites W2048540725 @default.
- W2154874694 cites W2058781371 @default.
- W2154874694 cites W2063497807 @default.
- W2154874694 cites W2065930081 @default.
- W2154874694 cites W2071985786 @default.
- W2154874694 cites W2078699094 @default.
- W2154874694 cites W2080435444 @default.
- W2154874694 cites W2086222358 @default.
- W2154874694 cites W2086417745 @default.
- W2154874694 cites W2090168014 @default.
- W2154874694 cites W2092095871 @default.
- W2154874694 cites W2095411130 @default.
- W2154874694 cites W2097009175 @default.
- W2154874694 cites W2098958083 @default.
- W2154874694 cites W2105910061 @default.
- W2154874694 cites W2108108310 @default.
- W2154874694 cites W2109032342 @default.
- W2154874694 cites W2118772333 @default.
- W2154874694 cites W2119013789 @default.
- W2154874694 cites W2120864356 @default.
- W2154874694 cites W2130797204 @default.
- W2154874694 cites W2137695731 @default.
- W2154874694 cites W2138733343 @default.
- W2154874694 cites W2151246207 @default.
- W2154874694 cites W2158847590 @default.
- W2154874694 cites W2164224003 @default.
- W2154874694 cites W2252334125 @default.
- W2154874694 cites W4234147211 @default.
- W2154874694 cites W4242789072 @default.
- W2154874694 doi "https://doi.org/10.4049/jimmunol.172.9.5338" @default.
- W2154874694 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2846334" @default.
- W2154874694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15100273" @default.
- W2154874694 hasPublicationYear "2004" @default.
- W2154874694 type Work @default.
- W2154874694 sameAs 2154874694 @default.
- W2154874694 citedByCount "34" @default.
- W2154874694 countsByYear W21548746942012 @default.
- W2154874694 countsByYear W21548746942013 @default.
- W2154874694 countsByYear W21548746942015 @default.
- W2154874694 crossrefType "journal-article" @default.
- W2154874694 hasAuthorship W2154874694A5013574133 @default.
- W2154874694 hasAuthorship W2154874694A5018380983 @default.
- W2154874694 hasAuthorship W2154874694A5019064202 @default.
- W2154874694 hasAuthorship W2154874694A5021846790 @default.
- W2154874694 hasAuthorship W2154874694A5068533682 @default.
- W2154874694 hasAuthorship W2154874694A5068712106 @default.
- W2154874694 hasAuthorship W2154874694A5082915839 @default.
- W2154874694 hasBestOaLocation W21548746941 @default.
- W2154874694 hasConcept C203014093 @default.
- W2154874694 hasConcept C2776090121 @default.
- W2154874694 hasConcept C2777701055 @default.
- W2154874694 hasConcept C2778690821 @default.
- W2154874694 hasConcept C502942594 @default.
- W2154874694 hasConcept C51785407 @default.
- W2154874694 hasConcept C86803240 @default.
- W2154874694 hasConcept C8891405 @default.
- W2154874694 hasConcept C90375314 @default.