FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154882011> ?p ?o ?g. }

• W2154882011 endingPage "4227" @default.
• W2154882011 startingPage "4220" @default.
• W2154882011 abstract "It is assumed that ERK2 in Dictyostelium is subject to adaptive regulation in response to constant extracellular ligand stimulation. We now show, to the contrary, that ERK2 remains active under continuous stimulation, differing from most ligand-activated pathways in chemotactically competent Dictyostelium and other cells. We show that the upstream phosphorylation pathway, responsible for ERK2 activation, transiently responds to receptor stimulation, whereas ERK2 dephosphorylation (deactivation) is inhibited by continuous stimulation. We argue that the net result of these two regulatory actions is a persistently active ERK2 pathway when the extracellular ligand (i.e., cAMP) concentration is held constant and that oscillatory production/destruction of secreted cAMP in chemotaxing cells accounts for the observed oscillatory activity of ERK2. We also show that pathways controlling seven-transmembrane receptor (7-TMR) ERK2 activation/deactivation function independently of G proteins and ligand-induced production of intracellular cAMP and the consequent activation of PKA. Finally, we propose that this regulation enables ERK2 to function both in an oscillatory manner, critical for chemotaxis, and in a persistent manner, necessary for gene expression, as secreted ligand concentration increases during later development. This work redefines mechanisms of ERK2 regulation by 7-TMR signaling in Dictyostelium and establishes new implications for control of signal relay during chemotaxis." @default.
• W2154882011 created "2016-06-24" @default.
• W2154882011 creator A5056347452 @default.
• W2154882011 creator A5077108242 @default.
• W2154882011 date "2006-10-01" @default.
• W2154882011 modified "2023-09-23" @default.
• W2154882011 title "Nonadaptive Regulation of ERK2 in<i>Dictyostelium</i>: Implications for Mechanisms of cAMP Relay" @default.
• W2154882011 cites W1523950365 @default.
• W2154882011 cites W1534130514 @default.
• W2154882011 cites W1538018548 @default.
• W2154882011 cites W1558300419 @default.
• W2154882011 cites W1559469796 @default.
• W2154882011 cites W1574770390 @default.
• W2154882011 cites W1973276488 @default.
• W2154882011 cites W1979204369 @default.
• W2154882011 cites W1984983230 @default.
• W2154882011 cites W1988467323 @default.
• W2154882011 cites W2017323590 @default.
• W2154882011 cites W2022907226 @default.
• W2154882011 cites W2029253559 @default.
• W2154882011 cites W2036145275 @default.
• W2154882011 cites W2050270315 @default.
• W2154882011 cites W2054110409 @default.
• W2154882011 cites W2058241031 @default.
• W2154882011 cites W2065666472 @default.
• W2154882011 cites W2071152953 @default.
• W2154882011 cites W2073171045 @default.
• W2154882011 cites W2077836253 @default.
• W2154882011 cites W2094253796 @default.
• W2154882011 cites W2117942544 @default.
• W2154882011 cites W2119783639 @default.
• W2154882011 cites W2122973170 @default.
• W2154882011 cites W2123482247 @default.
• W2154882011 cites W2125638123 @default.
• W2154882011 cites W2130138904 @default.
• W2154882011 cites W2131456214 @default.
• W2154882011 cites W2132548983 @default.
• W2154882011 cites W2135094217 @default.
• W2154882011 cites W2140975775 @default.
• W2154882011 cites W2142326135 @default.
• W2154882011 cites W2144099695 @default.
• W2154882011 cites W2158040291 @default.
• W2154882011 cites W2159750276 @default.
• W2154882011 cites W2166343829 @default.
• W2154882011 cites W2274168141 @default.
• W2154882011 cites W2398257858 @default.
• W2154882011 cites W253670182 @default.
• W2154882011 cites W2792659630 @default.
• W2154882011 doi "https://doi.org/10.1091/mbc.e06-05-0376" @default.
• W2154882011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1635358" @default.
• W2154882011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16870702" @default.
• W2154882011 hasPublicationYear "2006" @default.
• W2154882011 type Work @default.
• W2154882011 sameAs 2154882011 @default.
• W2154882011 citedByCount "32" @default.
• W2154882011 countsByYear W21548820112012 @default.
• W2154882011 countsByYear W21548820112013 @default.
• W2154882011 countsByYear W21548820112014 @default.
• W2154882011 countsByYear W21548820112015 @default.
• W2154882011 countsByYear W21548820112016 @default.
• W2154882011 countsByYear W21548820112017 @default.
• W2154882011 countsByYear W21548820112018 @default.
• W2154882011 countsByYear W21548820112019 @default.
• W2154882011 countsByYear W21548820112021 @default.
• W2154882011 crossrefType "journal-article" @default.
• W2154882011 hasAuthorship W2154882011A5056347452 @default.
• W2154882011 hasAuthorship W2154882011A5077108242 @default.
• W2154882011 hasBestOaLocation W21548820112 @default.
• W2154882011 hasConcept C104317684 @default.
• W2154882011 hasConcept C116569031 @default.
• W2154882011 hasConcept C11960822 @default.
• W2154882011 hasConcept C14036430 @default.
• W2154882011 hasConcept C169760540 @default.
• W2154882011 hasConcept C170493617 @default.
• W2154882011 hasConcept C178666793 @default.
• W2154882011 hasConcept C181912034 @default.
• W2154882011 hasConcept C24530287 @default.
• W2154882011 hasConcept C24998067 @default.
• W2154882011 hasConcept C2775889303 @default.
• W2154882011 hasConcept C28406088 @default.
• W2154882011 hasConcept C54166955 @default.
• W2154882011 hasConcept C55493867 @default.
• W2154882011 hasConcept C62478195 @default.
• W2154882011 hasConcept C79879829 @default.
• W2154882011 hasConcept C86803240 @default.
• W2154882011 hasConcept C95444343 @default.
• W2154882011 hasConceptScore W2154882011C104317684 @default.
• W2154882011 hasConceptScore W2154882011C116569031 @default.
• W2154882011 hasConceptScore W2154882011C11960822 @default.
• W2154882011 hasConceptScore W2154882011C14036430 @default.
• W2154882011 hasConceptScore W2154882011C169760540 @default.
• W2154882011 hasConceptScore W2154882011C170493617 @default.
• W2154882011 hasConceptScore W2154882011C178666793 @default.
• W2154882011 hasConceptScore W2154882011C181912034 @default.
• W2154882011 hasConceptScore W2154882011C24530287 @default.
• W2154882011 hasConceptScore W2154882011C24998067 @default.
• W2154882011 hasConceptScore W2154882011C2775889303 @default.
• W2154882011 hasConceptScore W2154882011C28406088 @default.

• next