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• W2154892007 abstract "ABSTRACT Dendritic cells (DCs) enhance human immunodeficiency virus type 1 (HIV-1) infection of CD4 + T lymphocytes in trans . The C-type lectin DC-SIGN, expressed on DCs, binds to the HIV-1 envelope glycoprotein gp120 and confers upon some cell lines the capacity to enhance trans -infection. Using a short hairpin RNA approach, we demonstrate that DC-SIGN is not required for efficient trans -enhancement by DCs. In addition, the DC-SIGN ligand mannan and an anti-DC-SIGN antibody did not inhibit DC-mediated enhancement. HIV-1 particles were internalized and were protected from protease treatment following binding to DCs, but not from binding to DC-SIGN-expressing Raji cells. Thus, DC-SIGN is not required for DC-mediated trans -enhancement of HIV infectivity." @default.
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• W2154892007 date "2007-03-01" @default.
• W2154892007 modified "2023-10-13" @default.
• W2154892007 title "Dendritic Cell-Mediated <i>trans</i> -Enhancement of Human Immunodeficiency Virus Type 1 Infectivity Is Independent of DC-SIGN" @default.
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• W2154892007 doi "https://doi.org/10.1128/jvi.01661-06" @default.
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