FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154894171> ?p ?o ?g. }

• W2154894171 endingPage "151" @default.
• W2154894171 startingPage "141" @default.
• W2154894171 abstract "A polymeric controlled release vaginal delivery system was developed for 15(S)15-methyl PGF2α methyl ester. This delivery system is a reservoir-type device consisting of laminated membranes that are mounted on an inert holder. The delivery systems were designed to have steady-state release rates of 50 or 100 μg/hr. Included in the study were seven early pregnant (amenorrhea up to 49 days) patients who were treated with 50 μg/hr devices and five early pregnant patients who were treated with 100 μg/hr devices. Three second-trimester cases received a 50 μg/hr device and five received a 100 μg/hr device. Five of the seven early first-trimester patients given 50 μg/hr devices aborted completely. The plasma levels of PG in those patients were 400–600 pg/ml for up to 6 hours. In the two cases that did not abort completely, the plasma levels of drug dropped sharply after both patients had started to bleed vaginally one hour after administration of the device. All five early pregnant patients treated with 100 μg/hr devices aborted completely. None of the three second-trimester cases aborted within 24 hours following administration of the 50 μg/hr devices. Three of the five second-trimester patients aborted within 24 hours following treatment with 100 μg/hr devices. The plasma levels of drug reached 1–1.5 ng/ml during the first 2–5 hours and then declined, especially after rupture of the membranes. The variation of plasma levels of drug following vaginal administration of the devices in different individuals was considerably less than following vaginal suppositories. Therefore, this device seems to be close to an ideal delivery system for vaginal administration of abortifacients." @default.
• W2154894171 created "2016-06-24" @default.
• W2154894171 creator A5008076365 @default.
• W2154894171 creator A5053467149 @default.
• W2154894171 creator A5076668891 @default.
• W2154894171 creator A5081165719 @default.
• W2154894171 creator A5083014815 @default.
• W2154894171 creator A5086354332 @default.
• W2154894171 creator A5038236628 @default.
• W2154894171 date "1983-02-01" @default.
• W2154894171 modified "2023-09-26" @default.
• W2154894171 title "Menses induction and second-trimester pregnancy termination using a polymeric controlled release vaginal delivery system containing (15S)15-methyl PGF2α methyl ester" @default.
• W2154894171 cites W2044327003 @default.
• W2154894171 cites W2070801021 @default.
• W2154894171 cites W2071738207 @default.
• W2154894171 cites W2072488248 @default.
• W2154894171 cites W2080001672 @default.
• W2154894171 cites W2086492542 @default.
• W2154894171 cites W2123518900 @default.
• W2154894171 doi "https://doi.org/10.1016/0010-7824(83)90085-9" @default.
• W2154894171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6303690" @default.
• W2154894171 hasPublicationYear "1983" @default.
• W2154894171 type Work @default.
• W2154894171 sameAs 2154894171 @default.
• W2154894171 citedByCount "8" @default.
• W2154894171 crossrefType "journal-article" @default.
• W2154894171 hasAuthorship W2154894171A5008076365 @default.
• W2154894171 hasAuthorship W2154894171A5038236628 @default.
• W2154894171 hasAuthorship W2154894171A5053467149 @default.
• W2154894171 hasAuthorship W2154894171A5076668891 @default.
• W2154894171 hasAuthorship W2154894171A5081165719 @default.
• W2154894171 hasAuthorship W2154894171A5083014815 @default.
• W2154894171 hasAuthorship W2154894171A5086354332 @default.
• W2154894171 hasConcept C141071460 @default.
• W2154894171 hasConcept C2776259030 @default.
• W2154894171 hasConcept C2778058571 @default.
• W2154894171 hasConcept C2779234561 @default.
• W2154894171 hasConcept C42219234 @default.
• W2154894171 hasConcept C54355233 @default.
• W2154894171 hasConcept C71924100 @default.
• W2154894171 hasConcept C86803240 @default.
• W2154894171 hasConceptScore W2154894171C141071460 @default.
• W2154894171 hasConceptScore W2154894171C2776259030 @default.
• W2154894171 hasConceptScore W2154894171C2778058571 @default.
• W2154894171 hasConceptScore W2154894171C2779234561 @default.
• W2154894171 hasConceptScore W2154894171C42219234 @default.
• W2154894171 hasConceptScore W2154894171C54355233 @default.
• W2154894171 hasConceptScore W2154894171C71924100 @default.
• W2154894171 hasConceptScore W2154894171C86803240 @default.
• W2154894171 hasIssue "2" @default.
• W2154894171 hasLocation W21548941711 @default.
• W2154894171 hasLocation W21548941712 @default.
• W2154894171 hasOpenAccess W2154894171 @default.
• W2154894171 hasPrimaryLocation W21548941711 @default.
• W2154894171 hasRelatedWork W141510843 @default.
• W2154894171 hasRelatedWork W2004163032 @default.
• W2154894171 hasRelatedWork W2049167364 @default.
• W2154894171 hasRelatedWork W2171937346 @default.
• W2154894171 hasRelatedWork W2287181544 @default.
• W2154894171 hasRelatedWork W2311019076 @default.
• W2154894171 hasRelatedWork W2360716590 @default.
• W2154894171 hasRelatedWork W2380971526 @default.
• W2154894171 hasRelatedWork W4293218309 @default.
• W2154894171 hasRelatedWork W4382881471 @default.
• W2154894171 hasVolume "27" @default.
• W2154894171 isParatext "false" @default.
• W2154894171 isRetracted "false" @default.
• W2154894171 magId "2154894171" @default.
• W2154894171 workType "article" @default.