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• W2154906910 abstract "Salmonella enterica subsp. enterica serovar Give is an enteric serotype frequently isolated from ruminants and pigs but rarely found in human hosts [1]. Between April and June 2004, an unusual increase was observed in the number of S. ser. Give isolates identified by several European national reference laboratories [2]. In 11 countries, 103 cases were detected, and only a minority of these infections was related to travel. Further European data suggest a recent increase in the prevalence and pathogenicity of S. ser. Give. For example, from March to July 2004, 115 cases of gastroenteritis caused by S. ser. Give were identified in Germany and these were mainly responsible for the increased number of cases reported in the Enter-net data of the international surveillance network for enteric infections during the second quarter of 2004 [3]. This nationwide outbreak was strongly associated with human consumption of raw minced pork (OR, 8.0; 95%CI, 2.3–27.7; p=0.001), and common outbreak strains were isolated from patients and pork samples. Compared to patients infected by S. ser. Enteritidis, the most common serovar in Germany, infections caused by S. ser. Give led to a higher hospitalization rate in patients older than 60 years (S. ser. Give 55%, S. ser. Enteritidis 33%; OR, 2.5; 95%CI, 1.1–5.4; p=0.02) [3]. The higher hospitalization rate observed for S. ser. Give possibly indicates this serotype has a higher virulence compared to other non-typhoidal Salmonella spp. Reported here is a clinical case of an immunocompetent patient presenting with splenic abscess due to S. ser. Give, which was possibly associated with consumption of raw minced meat. In March 2004, a 24-year-old Caucasian male returning from a vacation in southern Thailand with his family was admitted to our walk-in clinic with increasing fever, dyspnea and left shoulder pain. He had no medical history of note. He had been well until February 2004, when he suddenly developed a high fever, malaise, nausea, dry cough and increasing dyspnea. He received intramuscular penicillin G injections for 2 days without any improvement, then a combination of oral amoxicillin and clavulanic acid (625 mg tid) over 7 days for suspected bronchopneumonia of the left lower lobe. Five days following initiation of the second antibiotic therapy, the patient felt better and fever disappeared. Following completion of the antibiotic regimen, however, symptoms relapsed, with fever up to 40°C, chills, abdominal discomfort and unbearable left shoulder pain triggered by deep inspiration and coughing. Two days after completion of the oral regimen, the patient returned for further investigations. Physical examination revealed a body temperature of 38°C, dyspnea and polypnea (28/min), tachycardia (122/ min), diffuse subcutaneous edema, dull percussion at the left inferior thoracic base and hepatosplenomegaly. Laboratory tests revealed a raised C-reactive protein level (301 mg/l), leukocytosis (15×10/l) with a left shift (8%), thrombocytosis (804×10/l), hypoalbuminemia (17 g/l), and elevated liver enzymes (alanine aminotransferase 80, aspartate aminotransferase 37 U/l, gamma-glutamyl transpeptidase 288 U/l). Chest radiographs showed a raised and thickened left diaphragm with signs of an expanding mass with air fluid level and stomach compression in the left F. Girardin (*) Department of Community Medicine and Service of Clinical Pharmacology and Toxicology, Geneva University Hospitals, Micheli-du-Crest 24, 1205 Geneva, Switzerland e-mail: francois.girardin@hcuge.ch Tel.: +41-22-3055397 Fax: +41-22-3055309" @default.
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• W2154906910 date "2006-03-25" @default.
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• W2154906910 title "Salmonella serovar Give: an unusual pathogen causing splenic abscess" @default.
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• W2154906910 doi "https://doi.org/10.1007/s10096-006-0122-2" @default.
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