FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154909187> ?p ?o ?g. }

• W2154909187 endingPage "494" @default.
• W2154909187 startingPage "489" @default.
• W2154909187 abstract "No AccessJournal of UrologyAdult Urology1 Feb 2011Single Focus Prostate Cancer: Pathological Features and ERG Fusion Status Sara M. Falzarano, Ming Zhou, Adrian V. Hernandez, Eric A. Klein, Mark A. Rubin, and Cristina Magi-Galluzzi Sara M. FalzaranoSara M. Falzarano Division of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio Department of Pathology and Human Oncology, University of Siena, Siena, Italy More articles by this author , Ming ZhouMing Zhou Division of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio More articles by this author , Adrian V. HernandezAdrian V. Hernandez Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio More articles by this author , Eric A. KleinEric A. Klein Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio More articles by this author , Mark A. RubinMark A. Rubin Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York More articles by this author , and Cristina Magi-GalluzziCristina Magi-Galluzzi Division of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.09.093AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated the clinicopathological characteristics of single focus prostate cancer in radical prostatectomies, its clinical relevance and the occurrence of TMPRSS2-ERG rearrangement. Materials and Methods: We reviewed the records of 1,100 radical prostatectomies and determined the tumor outline and number of cancer foci. When single focus prostate cancer was identified, we recorded pathological characteristics. We assessed ERG fusion status in a subset of cases. Results: Single focus prostate cancer was identified in 106 radical prostatectomies. Median patient age was 59 years. Median prostate specific antigen was 5.1 ng/ml. Single focus cancer was unilateral in 81% of cases and 98% originated from the peripheral zone. Tumor volume was 0.1 to 3.9 cm3 (median 0.5). Gleason score was 6 in 38% of patients, 7 in 40%, 8 or greater in 21% and undetermined in 2%. Extraprostatic extension and seminal vesicles invasion were detected in 30% and 2% of cases, respectively. Stage was pT2 in 62% of cases, pT2 with positive margin of resection in 7% and pT3 in 30%. ERG fusion was detected in 68% of tumors. Cases rearranged via deletion had significantly higher tumor volume. Three cases showed intratumor heterogeneity. Conclusions: Single focus prostate cancer accounted for 9.6% of tumors. In most cases it involved 1 lobe of the gland and originated from the peripheral zone. Despite a trend toward high grade disease 62% of single focus prostate cancers were organ confined. Only 3 fusion positive cases showed intratumor heterogeneity, suggesting that most single focus cancer may evolve from a single clone of malignant cells. References 1 : Carcinoma of the prostate: prognostic evaluation of certain pathologic features in 208 radical prostatectomies: Examined by the step-section technique . Cancer1972; 30: 5. Google Scholar 2 : Multiple cancers in the prostate. Morphologic features of clinically recognized versus incidental tumors. Cancer1992; 70: 2313. Google Scholar 3 : Heterogeneity of Gleason grade in multifocal adenocarcinoma of the prostate. Cancer2004; 100: 2362. Google Scholar 4 : Morphology of prostate cancer: the effects of multifocality on histological grade, tumor volume and capsule penetration. J Urol1994; 152: 1709. Link, Google Scholar 5 : Prognostic factors for multifocal prostate cancer in radical prostatectomy specimens: lack of significance of secondary cancers. J Urol2003; 170: 459. Link, Google Scholar 6 : Clinicopathological behavior of single focus prostate adenocarcinoma. J Urol2009; 182: 2689. Link, Google Scholar 7 : Morphologic and clinical significance of multifocal prostate cancers in radical prostatectomy specimens. Urology2002; 60: 264. Google Scholar 8 : Mapping of TMPRSS2-ERG fusions in the context of multi-focal prostate cancer. Mod Pathol2008; 21: 67. Google Scholar 9 : Heterogeneity of TMPRSS2 gene rearrangements in multifocal prostate adenocarcinoma: molecular evidence for an independent group of diseases. Cancer Res2007; 67: 7991. Google Scholar 10 : TMPRSS2: ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer. Cancer Res2006; 66: 8337. Google Scholar 11 : Duplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate cancer. Oncogene2008; 27: 253. Google Scholar 12 : TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions. Neoplasia2006; 8: 826. Google Scholar 13 : TMPRSS2: ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort. Oncogene2007; 26: 4596. Google Scholar 14 : Comprehensive assessment of TMPRSS2 and ETS family gene aberrations in clinically localized prostate cancer. Mod Pathol2007; 20: 538. Google Scholar 15 : Morphological features of TMPRSS2-ERG gene fusion prostate cancer. J Pathol2007; 212: 91. Google Scholar 16 : Expression of TMPRSS2: ERG gene fusion in prostate cancer cells is an important prognostic factor for cancer progression. Cancer Biol Ther2007; 6: 40. Google Scholar 17 : Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science2005; 310: 644. Google Scholar 18 : TMPRSS2-ERG fusion heterogeneity in multifocal prostate cancer: clinical and biologic implications. Urology2007; 70: 630. Google Scholar 19 : The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma. Am J Surg Pathol2005; 29: 1228. Google Scholar 20 : A streamlined three-dimensional volume estimation method accurately classifies prostate tumors by volume. Am J Surg Pathol2003; 27: 1291. Google Scholar 21 : TMPRSS2-ERG fusion prostate cancer: an early molecular event associated with invasion. Am J Surg Pathol2007; 31: 882. Google Scholar 22 : Overexpression, amplification, and androgen regulation of TPD52 in prostate cancer. Cancer Res2004; 64: 3814. Google Scholar 23 : Detailed mapping of prostate carcinoma foci: biopsy strategy implications. Cancer2000; 89: 1800. Google Scholar 24 : Independent origin of multiple foci of prostatic intraepithelial neoplasia: comparison with matched foci of prostate carcinoma. Cancer1998; 83: 1995. Google Scholar 25 : Oncologic outcome after laparoscopic radical prostatectomy: 10 years of experience. Eur Urol2009; 55: 1014. Google Scholar 26 : Oncologic outcome after extraperitoneal laparoscopic radical prostatectomy: midterm follow-up of 1115 procedures. Eur Urol2010; 57: 267. Google Scholar 27 : TMPRSS2-ERG gene fusion status in minute (minimal) prostatic adenocarcinoma. Mod Pathol2009; 22: 1415. Google Scholar 28 : Prostate cancer of transition zone origin lacks TMPRSS2-ERG gene fusion. Mod Pathol2009; 22: 866. Google Scholar 29 : ERG rearrangement is present in a subset of transition zone prostatic tumors. Mod Pathol2010; 23: 1499. Google Scholar 30 Aubin SM, Tomlins SA, Sakamoto K et al: Urine measurement of TMPRSS2:ERG for the early detection of significant prostate cancer. Presented at American Society of Clinical Oncology Genitourinary Cancers Symposium, March 5–7, 2010, San Francisco, California, abstract 1. Google Scholar © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 2February 2011Page: 489-494 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.Keywordscarcinomagene expressionprostatectomyprostateprostatic neoplasmsMetricsAuthor Information Sara M. Falzarano Division of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio Department of Pathology and Human Oncology, University of Siena, Siena, Italy More articles by this author Ming Zhou Division of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio More articles by this author Adrian V. Hernandez Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio More articles by this author Eric A. Klein Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio More articles by this author Mark A. Rubin Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York More articles by this author Cristina Magi-Galluzzi Division of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio More articles by this author Expand All Advertisement PDF DownloadLoading ..." @default.
• W2154909187 created "2016-06-24" @default.
• W2154909187 creator A5001069772 @default.
• W2154909187 creator A5034716746 @default.
• W2154909187 creator A5035068594 @default.
• W2154909187 creator A5064373607 @default.
• W2154909187 creator A5068186079 @default.
• W2154909187 creator A5078651786 @default.
• W2154909187 date "2011-02-01" @default.
• W2154909187 modified "2023-10-18" @default.
• W2154909187 title "Single Focus Prostate Cancer: Pathological Features and ERG Fusion Status" @default.
• W2154909187 cites W1496291651 @default.
• W2154909187 cites W1966187746 @default.
• W2154909187 cites W1968093710 @default.
• W2154909187 cites W1970122140 @default.
• W2154909187 cites W1986927943 @default.
• W2154909187 cites W1995021187 @default.
• W2154909187 cites W1995156882 @default.
• W2154909187 cites W2001928302 @default.
• W2154909187 cites W2002846943 @default.
• W2154909187 cites W2005841299 @default.
• W2154909187 cites W2018560195 @default.
• W2154909187 cites W2023922025 @default.
• W2154909187 cites W2038519284 @default.
• W2154909187 cites W2041002214 @default.
• W2154909187 cites W2046003313 @default.
• W2154909187 cites W2059103408 @default.
• W2154909187 cites W2060205498 @default.
• W2154909187 cites W2061891797 @default.
• W2154909187 cites W2069467496 @default.
• W2154909187 cites W2083043726 @default.
• W2154909187 cites W2088534993 @default.
• W2154909187 cites W2096800294 @default.
• W2154909187 cites W2117936087 @default.
• W2154909187 cites W2121158863 @default.
• W2154909187 cites W2136180772 @default.
• W2154909187 cites W2143841774 @default.
• W2154909187 cites W2147489040 @default.
• W2154909187 cites W2404165232 @default.
• W2154909187 doi "https://doi.org/10.1016/j.juro.2010.09.093" @default.
• W2154909187 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21167530" @default.
• W2154909187 hasPublicationYear "2011" @default.
• W2154909187 type Work @default.
• W2154909187 sameAs 2154909187 @default.
• W2154909187 citedByCount "15" @default.
• W2154909187 countsByYear W21549091872012 @default.
• W2154909187 countsByYear W21549091872013 @default.
• W2154909187 countsByYear W21549091872014 @default.
• W2154909187 countsByYear W21549091872015 @default.
• W2154909187 countsByYear W21549091872022 @default.
• W2154909187 crossrefType "journal-article" @default.
• W2154909187 hasAuthorship W2154909187A5001069772 @default.
• W2154909187 hasAuthorship W2154909187A5034716746 @default.
• W2154909187 hasAuthorship W2154909187A5035068594 @default.
• W2154909187 hasAuthorship W2154909187A5064373607 @default.
• W2154909187 hasAuthorship W2154909187A5068186079 @default.
• W2154909187 hasAuthorship W2154909187A5078651786 @default.
• W2154909187 hasConcept C103796816 @default.
• W2154909187 hasConcept C118487528 @default.
• W2154909187 hasConcept C120665830 @default.
• W2154909187 hasConcept C121332964 @default.
• W2154909187 hasConcept C121608353 @default.
• W2154909187 hasConcept C126322002 @default.
• W2154909187 hasConcept C143998085 @default.
• W2154909187 hasConcept C192209626 @default.
• W2154909187 hasConcept C207886595 @default.
• W2154909187 hasConcept C2776235491 @default.
• W2154909187 hasConcept C2778042024 @default.
• W2154909187 hasConcept C2779134260 @default.
• W2154909187 hasConcept C2780192828 @default.
• W2154909187 hasConcept C2780827179 @default.
• W2154909187 hasConcept C3008058167 @default.
• W2154909187 hasConcept C524204448 @default.
• W2154909187 hasConcept C71924100 @default.
• W2154909187 hasConceptScore W2154909187C103796816 @default.
• W2154909187 hasConceptScore W2154909187C118487528 @default.
• W2154909187 hasConceptScore W2154909187C120665830 @default.
• W2154909187 hasConceptScore W2154909187C121332964 @default.
• W2154909187 hasConceptScore W2154909187C121608353 @default.
• W2154909187 hasConceptScore W2154909187C126322002 @default.
• W2154909187 hasConceptScore W2154909187C143998085 @default.
• W2154909187 hasConceptScore W2154909187C192209626 @default.
• W2154909187 hasConceptScore W2154909187C207886595 @default.
• W2154909187 hasConceptScore W2154909187C2776235491 @default.
• W2154909187 hasConceptScore W2154909187C2778042024 @default.
• W2154909187 hasConceptScore W2154909187C2779134260 @default.
• W2154909187 hasConceptScore W2154909187C2780192828 @default.
• W2154909187 hasConceptScore W2154909187C2780827179 @default.
• W2154909187 hasConceptScore W2154909187C3008058167 @default.
• W2154909187 hasConceptScore W2154909187C524204448 @default.
• W2154909187 hasConceptScore W2154909187C71924100 @default.
• W2154909187 hasIssue "2" @default.
• W2154909187 hasLocation W21549091871 @default.
• W2154909187 hasLocation W21549091872 @default.
• W2154909187 hasOpenAccess W2154909187 @default.
• W2154909187 hasPrimaryLocation W21549091871 @default.
• W2154909187 hasRelatedWork W1959266681 @default.
• W2154909187 hasRelatedWork W2026660392 @default.

• next