Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154913159> ?p ?o ?g. }
- W2154913159 endingPage "2843" @default.
- W2154913159 startingPage "2832" @default.
- W2154913159 abstract "Abstract Abs have a paramount place in the treatment of certain, mainly lymphoid, malignancies, although tumors of nonhemopoietic origin have proved more refractory ones. We have previously shown that the efficacy of immunotherapy of solid tumors, in particular ovarian carcinoma, may be improved by the use of IgE Abs in place of the conventional IgG. An IgE Ab (MOv18 IgE) against an ovarian-tumor-specific Ag (folate binding protein), in combination with human PBMC, introduced into ovarian cancer xenograft-bearing mice, greatly exceeded the analogous IgG1 in promoting survival. In this study, we analyzed the mechanisms by which MOv18 IgE may exert its antitumor activities. Monocytes were essential IgE receptor-expressing effector cells that mediated the enhanced survival of tumor-bearing mice by MOv18 IgE and human PBMC. Monocytes mediated MOv18 IgE-dependent ovarian tumor cell killing in vitro by two distinct pathways, cytotoxicity and phagocytosis, acting respectively through the IgE receptors FcεRI and CD23. We also show that human eosinophils were potent effector cells in MOv18 IgE Ab-dependent ovarian tumor cell cytotoxicity in vitro. These results demonstrate that IgE Abs can engage cell surface IgE receptors and activate effector cells against ovarian tumor cells. Our findings offer a framework for an improved immunotherapeutic strategy for combating solid tumors." @default.
- W2154913159 created "2016-06-24" @default.
- W2154913159 creator A5001525881 @default.
- W2154913159 creator A5025344866 @default.
- W2154913159 creator A5038459518 @default.
- W2154913159 creator A5038858265 @default.
- W2154913159 creator A5050335418 @default.
- W2154913159 creator A5052503822 @default.
- W2154913159 creator A5056823014 @default.
- W2154913159 creator A5064339857 @default.
- W2154913159 creator A5066852123 @default.
- W2154913159 creator A5086640960 @default.
- W2154913159 creator A5087765468 @default.
- W2154913159 creator A5087920627 @default.
- W2154913159 creator A5088694148 @default.
- W2154913159 creator A5091236180 @default.
- W2154913159 date "2007-09-01" @default.
- W2154913159 modified "2023-10-10" @default.
- W2154913159 title "IgE-Antibody-Dependent Immunotherapy of Solid Tumors: Cytotoxic and Phagocytic Mechanisms of Eradication of Ovarian Cancer Cells" @default.
- W2154913159 cites W1516451902 @default.
- W2154913159 cites W1522506802 @default.
- W2154913159 cites W1582824294 @default.
- W2154913159 cites W1609910491 @default.
- W2154913159 cites W1679033430 @default.
- W2154913159 cites W174805935 @default.
- W2154913159 cites W1920308570 @default.
- W2154913159 cites W1929537823 @default.
- W2154913159 cites W1970626272 @default.
- W2154913159 cites W1971341208 @default.
- W2154913159 cites W1972311005 @default.
- W2154913159 cites W1974305968 @default.
- W2154913159 cites W1978037481 @default.
- W2154913159 cites W1980799332 @default.
- W2154913159 cites W1981422705 @default.
- W2154913159 cites W1984366825 @default.
- W2154913159 cites W1984829276 @default.
- W2154913159 cites W1987753834 @default.
- W2154913159 cites W1990367169 @default.
- W2154913159 cites W1998665610 @default.
- W2154913159 cites W1999546300 @default.
- W2154913159 cites W2010525353 @default.
- W2154913159 cites W2011646184 @default.
- W2154913159 cites W2013613367 @default.
- W2154913159 cites W2018411113 @default.
- W2154913159 cites W2022817622 @default.
- W2154913159 cites W2023095985 @default.
- W2154913159 cites W2023879989 @default.
- W2154913159 cites W2024428046 @default.
- W2154913159 cites W2048809358 @default.
- W2154913159 cites W2055585136 @default.
- W2154913159 cites W2068540199 @default.
- W2154913159 cites W2073704480 @default.
- W2154913159 cites W2077712995 @default.
- W2154913159 cites W2083310288 @default.
- W2154913159 cites W2083408248 @default.
- W2154913159 cites W2085990604 @default.
- W2154913159 cites W2091372479 @default.
- W2154913159 cites W2095580062 @default.
- W2154913159 cites W2100834680 @default.
- W2154913159 cites W2106833014 @default.
- W2154913159 cites W2108782816 @default.
- W2154913159 cites W2110562475 @default.
- W2154913159 cites W2120948675 @default.
- W2154913159 cites W2122895790 @default.
- W2154913159 cites W2127386794 @default.
- W2154913159 cites W2128402413 @default.
- W2154913159 cites W2133999831 @default.
- W2154913159 cites W2142577215 @default.
- W2154913159 cites W2148962946 @default.
- W2154913159 cites W2155473397 @default.
- W2154913159 cites W2160139360 @default.
- W2154913159 cites W2164757740 @default.
- W2154913159 cites W2165118000 @default.
- W2154913159 cites W2170320784 @default.
- W2154913159 cites W2188497729 @default.
- W2154913159 cites W2430242855 @default.
- W2154913159 cites W4229738646 @default.
- W2154913159 cites W4246818975 @default.
- W2154913159 cites W4249736906 @default.
- W2154913159 doi "https://doi.org/10.4049/jimmunol.179.5.2832" @default.
- W2154913159 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17709497" @default.
- W2154913159 hasPublicationYear "2007" @default.
- W2154913159 type Work @default.
- W2154913159 sameAs 2154913159 @default.
- W2154913159 citedByCount "99" @default.
- W2154913159 countsByYear W21549131592012 @default.
- W2154913159 countsByYear W21549131592013 @default.
- W2154913159 countsByYear W21549131592014 @default.
- W2154913159 countsByYear W21549131592015 @default.
- W2154913159 countsByYear W21549131592016 @default.
- W2154913159 countsByYear W21549131592017 @default.
- W2154913159 countsByYear W21549131592018 @default.
- W2154913159 countsByYear W21549131592019 @default.
- W2154913159 countsByYear W21549131592020 @default.
- W2154913159 countsByYear W21549131592021 @default.
- W2154913159 countsByYear W21549131592022 @default.
- W2154913159 countsByYear W21549131592023 @default.
- W2154913159 crossrefType "journal-article" @default.