FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154914397> ?p ?o ?g. }

• W2154914397 endingPage "871" @default.
• W2154914397 startingPage "866" @default.
• W2154914397 abstract "Objective. To identify soluble biomarkers associated with response to therapy with tumor necrosis factor inhibitors (TNFi) in patients with psoriatic arthritis (PsA). Methods. The study was conducted at a PsA clinic where patients are assessed every 6 months, and serum samples are collected and stored once a year at the time of clinical assessment. Forty patients with active PsA who gave serum samples prior to treatment with TNFi and after at least 3 months of therapy were identified. Patients were classified as TNFi responders if tender joint count was < 3, swollen joint count was 0, and Psoriasis Area and Severity Index score was < 4 at the time the second sample was collected. The following biomarkers were tested by ELISA: TNF superfamily 14, matrix metalloprotease-3 (MMP-3), receptor activator of nuclear factor kappa-B ligand, osteoprotegerin, cartilage oligomeric matrix protein (COMP), CPII, C2C and C1-2C, CS-846, and highly sensitive C-reactive protein. Paired t tests and logistic regression was used for statistical analyses. Results. After a mean treatment duration of 11 months with TNFi (etanercept 28 patients, adalimumab 6, golimumab 4, infliximab 2), 29 patients were classified as TNFi responders. Baseline level of MMP-3 was independently associated with responder status (OR 1.067 for each 1-unit increase, p = 0.045). A reduction in MMP-3 levels with therapy increased the odds of achieving response (OR 1.213 for each 1-unit change, p = 0.030), whereas a reduction in COMP decreased the odds (OR 0.587, for each 100-unit increase, p = 0.039). None of the other biomarkers was associated with response. Conclusion. Baseline as well as reduction in serum MMP-3 and increase in serum COMP are independently associated with response to TNFi therapy in patients with PsA." @default.
• W2154914397 created "2016-06-24" @default.
• W2154914397 creator A5013054661 @default.
• W2154914397 creator A5019158065 @default.
• W2154914397 creator A5049489990 @default.
• W2154914397 creator A5054553011 @default.
• W2154914397 creator A5076364548 @default.
• W2154914397 creator A5079058798 @default.
• W2154914397 creator A5088155787 @default.
• W2154914397 date "2013-05-01" @default.
• W2154914397 modified "2023-09-27" @default.
• W2154914397 title "Soluble Biomarkers Associated with Response to Treatment with Tumor Necrosis Factor Inhibitors in Psoriatic Arthritis" @default.
• W2154914397 cites W1492770235 @default.
• W2154914397 cites W1965690582 @default.
• W2154914397 cites W1970373563 @default.
• W2154914397 cites W1970758842 @default.
• W2154914397 cites W1991844077 @default.
• W2154914397 cites W2007734100 @default.
• W2154914397 cites W2010294534 @default.
• W2154914397 cites W2019011319 @default.
• W2154914397 cites W2019918070 @default.
• W2154914397 cites W2022509414 @default.
• W2154914397 cites W2037356704 @default.
• W2154914397 cites W2050839551 @default.
• W2154914397 cites W2052822538 @default.
• W2154914397 cites W2053947687 @default.
• W2154914397 cites W2082803782 @default.
• W2154914397 cites W2083180635 @default.
• W2154914397 cites W2088103742 @default.
• W2154914397 cites W2097842764 @default.
• W2154914397 cites W2109655567 @default.
• W2154914397 cites W2113717019 @default.
• W2154914397 cites W2118176175 @default.
• W2154914397 cites W2123784732 @default.
• W2154914397 cites W2125723356 @default.
• W2154914397 cites W2132717463 @default.
• W2154914397 cites W2154814233 @default.
• W2154914397 cites W2156291147 @default.
• W2154914397 cites W2160501399 @default.
• W2154914397 cites W2167617183 @default.
• W2154914397 cites W2170800858 @default.
• W2154914397 cites W2170891144 @default.
• W2154914397 cites W4211046919 @default.
• W2154914397 cites W4239251959 @default.
• W2154914397 cites W91108901 @default.
• W2154914397 doi "https://doi.org/10.3899/jrheum.121162" @default.
• W2154914397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23637322" @default.
• W2154914397 hasPublicationYear "2013" @default.
• W2154914397 type Work @default.
• W2154914397 sameAs 2154914397 @default.
• W2154914397 citedByCount "47" @default.
• W2154914397 countsByYear W21549143972014 @default.
• W2154914397 countsByYear W21549143972015 @default.
• W2154914397 countsByYear W21549143972016 @default.
• W2154914397 countsByYear W21549143972017 @default.
• W2154914397 countsByYear W21549143972018 @default.
• W2154914397 countsByYear W21549143972019 @default.
• W2154914397 countsByYear W21549143972020 @default.
• W2154914397 countsByYear W21549143972021 @default.
• W2154914397 countsByYear W21549143972022 @default.
• W2154914397 countsByYear W21549143972023 @default.
• W2154914397 crossrefType "journal-article" @default.
• W2154914397 hasAuthorship W2154914397A5013054661 @default.
• W2154914397 hasAuthorship W2154914397A5019158065 @default.
• W2154914397 hasAuthorship W2154914397A5049489990 @default.
• W2154914397 hasAuthorship W2154914397A5054553011 @default.
• W2154914397 hasAuthorship W2154914397A5076364548 @default.
• W2154914397 hasAuthorship W2154914397A5079058798 @default.
• W2154914397 hasAuthorship W2154914397A5088155787 @default.
• W2154914397 hasConcept C126322002 @default.
• W2154914397 hasConcept C156957248 @default.
• W2154914397 hasConcept C170493617 @default.
• W2154914397 hasConcept C17991360 @default.
• W2154914397 hasConcept C203014093 @default.
• W2154914397 hasConcept C2776260265 @default.
• W2154914397 hasConcept C2777011040 @default.
• W2154914397 hasConcept C2777138892 @default.
• W2154914397 hasConcept C2777226972 @default.
• W2154914397 hasConcept C2777575956 @default.
• W2154914397 hasConcept C2780132546 @default.
• W2154914397 hasConcept C2780426850 @default.
• W2154914397 hasConcept C2780564577 @default.
• W2154914397 hasConcept C2781290027 @default.
• W2154914397 hasConcept C71924100 @default.
• W2154914397 hasConcept C88045685 @default.
• W2154914397 hasConcept C90924648 @default.
• W2154914397 hasConceptScore W2154914397C126322002 @default.
• W2154914397 hasConceptScore W2154914397C156957248 @default.
• W2154914397 hasConceptScore W2154914397C170493617 @default.
• W2154914397 hasConceptScore W2154914397C17991360 @default.
• W2154914397 hasConceptScore W2154914397C203014093 @default.
• W2154914397 hasConceptScore W2154914397C2776260265 @default.
• W2154914397 hasConceptScore W2154914397C2777011040 @default.
• W2154914397 hasConceptScore W2154914397C2777138892 @default.
• W2154914397 hasConceptScore W2154914397C2777226972 @default.
• W2154914397 hasConceptScore W2154914397C2777575956 @default.
• W2154914397 hasConceptScore W2154914397C2780132546 @default.
• W2154914397 hasConceptScore W2154914397C2780426850 @default.

• next