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- W2154915512 endingPage "367" @default.
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- W2154915512 abstract "Treatment of multidrug-resistant tuberculosis (MDR-TB) is challenging because of the high toxicity of second-line drugs and the longer treatment duration required compared with drug-susceptible TB. The efficacy of treatment for MDR-TB is poorer than that for drug-susceptible TB. The selection of drugs in MDR-TB is based on previous treatment history, drug susceptibility results, and TB drug resistance patterns in the each region. Recent World Health Organization guidelines recommend the use of least 4 second-line drugs (a newer fluoroquinolone, an injectable agent, prothionamide, and cycloserine or para-aminosalicylic acid) in addition to pyrazinamide. The kanamycin is the initial choice of injectable durgs, and newer fluoroquinolones include levofloxacin and moxifloxacin. For MDR-TB, especially cases that are extensively drug-resistant, group 5 drugs such as linezolid, clofazimine, and amoxicillin/clavulanate need to be included. New agents with novel mechanisms of action that can be given for shorter durations (9-12 months) for MDR-TB are under investigation." @default.
- W2154915512 created "2016-06-24" @default.
- W2154915512 creator A5021717946 @default.
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- W2154915512 date "2013-01-01" @default.
- W2154915512 modified "2023-09-23" @default.
- W2154915512 title "Medical Treatment of Pulmonary Multidrug-Resistant Tuberculosis" @default.
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- W2154915512 doi "https://doi.org/10.3947/ic.2013.45.4.367" @default.
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