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• W2154920284 abstract "Abstract Molting in decapod crustaceans is regulated by molt-inhibiting hormone (MIH), a neuropeptide produced in the X-organ (XO)/sinus gland (SG) complex of the eyestalk ganglia (ESG). Pulsatile release of MIH from the SG suppresses ecdysteroidogenesis by the molting gland or Y-organ (YO). The hypothesis is that nitric oxide (NO), a neuromodulator that controls neurotransmitter release at presynaptic membranes, depresses the frequency and/or amount of MIH pulses to induce molting. NO synthase (NOS) mRNA was present in Carcinus maneas ESG and other tissues and NOS protein was present in the SG. A copper based ligand (CuFL), which reacts with NO to form a highly fluorescent product (NO-FL), was used to image NO in the ESG and SG and quantify the effects of NO scavenger (1 mM cPTIO), NOS inhibitor (1 mM L-NAME), and 1 mM sodium azide (NaN3) on NO production in the SG. Preincubation with cPTIO prior to CuFL loading decreased NO-FL fluorescence ~30%; including L-NAME had no additional effect. Incubating SG with L-NAME during preincubation and loading decreased NO-FL fluorescence ~40%, indicating that over half of the NO release was not directly dependent on NOS activity. Azide, which reacts with NO-binding metal groups in proteins, reduced NO-FL fluorescence to near background levels without extensive cell death. Spectral shift analysis showed that azide displaced NO from a soluble protein in SG extract. These data suggest that the SG contains NO-binding protein(s) that sequester NO and releases it over a prolonged period. This NO release may modulate neuropeptide secretion from the axon termini in the SG." @default.
• W2154920284 created "2016-06-24" @default.
• W2154920284 creator A5063484978 @default.
• W2154920284 creator A5084534479 @default.
• W2154920284 date "2014-01-01" @default.
• W2154920284 modified "2023-09-27" @default.
• W2154920284 title "Nitric oxide production and sequestration in the sinus gland of the green shore crab, <i>Carcinus maneas</i>" @default.
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• W2154920284 doi "https://doi.org/10.1242/jeb.113522" @default.
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