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• W2154923701 abstract "Studies of skin in amyotrophic lateral sclerosis (ALS) have demonstrated morphological and biochemical alterations. Interleukin-6 (IL-6) has been suggested to have a trophic effect in nerve cells and to have a direct pathogenic role in neurodegenerative central nervous system (CNS) disorders. However, little is known concerning IL-6 in ALS patients. We examined IL-6 immunoreactivity of biopsy specimens of skin and measured serum IL-6 levels from 11 ALS patients and 11 diseased control subjects. IL-6 immunoreactivity was markedly positive in the epidermis and dermal blood vessels and glands and was moderately positive in the reticular dermis in all ALS patients. These optical densities for IL-6 immunoreactivity in ALS patients were significantly higher than in control subjects, and were significantly increased with duration of illness. Serum IL-6 levels were detected in 8 (73%) of 11 ALS patients compared with only 1 (9%) of 11 diseased control subjects. Serum IL-6 levels were significantly correlated with duration of illness in ALS patients and immunoreactivity of IL-6 of the epidermis. These data suggest that the increased levels of serum IL-6 may reflect an increased IL-6 immunoreactivity of skin in ALS patients." @default.
• W2154923701 created "2016-06-24" @default.
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• W2154923701 date "2001-06-01" @default.
• W2154923701 modified "2023-09-30" @default.
• W2154923701 title "Increased interleukin-6 of skin and serum in amyotrophic lateral sclerosis" @default.
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• W2154923701 doi "https://doi.org/10.1016/s0022-510x(01)00514-7" @default.
• W2154923701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11440741" @default.
• W2154923701 hasPublicationYear "2001" @default.
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