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- W2154924325 abstract "Multi-drug resistant pulmonary tuberculosis (MDR-TB) may result from either insufficiency of the host cellular immune response or mycobacterial mechanisms of resistance. Mycobacterium tuberculosis-specific CD8+ and CD4+ T lymphocytes from MDR-TB patients are poorly studied. The aim of this study was to evaluate CD4+IFN-γ+, CD4+IL-10+, CD8+IFN-γ+ and CD8+IL-10+ cell populations by flow cytometry in non-resistant TB and multi-drug resistant tuberculosis (MDR-TB) patients from mid-central Brazil after stimulation with MPT-51, GlcB and ESAT-6 recombinant antigens from M. tuberculosis in comparison to tuberculin skin test negative (TST) healthy individuals. Non-resistant TB patients present specific cellular responses (CD4 and CD8, both IFN-γ and IL-10) to GlcB, MPT-51 and ESAT-6; while MDR-TB patients present only CD8+IFN-γ+ responses to ESAT-6 and CD8+IL-10+ responses to GlcB and ESAT-6. The results show that MDR-TB patients present impaired specific CD4 IFN-γ and IL-10 responses and increased/normal specific CD8 IFN-γ and IL-10 responses. This suggests an important role for CD8 function in these patients." @default.
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- W2154924325 date "2008-09-01" @default.
- W2154924325 modified "2023-09-26" @default.
- W2154924325 title "Cellular responses to MPT-51, GlcB and ESAT-6 among MDR-TB and active tuberculosis patients in Brazil" @default.
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- W2154924325 doi "https://doi.org/10.1016/j.tube.2008.06.002" @default.
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