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- W2154927995 abstract "Primary guinea pig cardiac-derived cells were established in vitro employing Lab-Tek tissue culture chambers. Monolayer development of pass No. 1 cells was found to fit the growth curve , with the average correlation index (C.I.) equal to 0.99. The cytotoxic effect on monolayer development of anti-human, anti-rabbit, and anti-guinea pig heart antibodies on guinea pig cardiac-derived cell growth was studied and found not to be completely species specific. The presence of complement was necessary for any growth inhibition or cytotoxicity. While an absolute species specific effect was not established, milder growth inhibition patterns were noted in the heterologous systems compared to a marked cytotoxic effect in the homologous system. When the guinea pig cardiac-derived cells were grown in the presence of antiguinea pig heart antiserum alone, the average correlation index was 0.96 and A = 0.204. With the addition of complement, the C.I. dropped to 0.003. This departure from the expected values for the growth curve indicated complement-dependent cytotoxicity. Cross-reactivity between the cytotoxic and anti-guinea pig heart antibodies and streptococcal serological M antigen types M-1, 5, and 12 was not found. These results were confirmed by passive hemagglutination and gel precipitation, with the exception of an equivocal cross-reactive antigen between M-12 and guinea pig heart acid extract. Nevertheless, there was no evidence in this report to validate previous suggestions that the beta hemolytic Group A streptococcal M-type antigens play a significant part in causing cardiac cell damage through stimulation of anti-heart antibody production." @default.
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- W2154927995 date "1973-12-01" @default.
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- W2154927995 title "A specific cytotoxic effect of anti-heart antibodies on cardiac-derived cells in a newly defined in vitro system" @default.
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- W2154927995 doi "https://doi.org/10.1016/0022-2828(73)90005-9" @default.
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