FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154937658> ?p ?o ?g. }

• W2154937658 endingPage "1492" @default.
• W2154937658 startingPage "1483" @default.
• W2154937658 abstract "Monitoring of HIV viral load in patients on combination antiretroviral therapy (ART) is not generally available in resource-limited settings. We examined the cost-effectiveness of qualitative point-of-care viral load tests (POC-VL) in sub-Saharan Africa.Mathematical model based on longitudinal data from the Gugulethu and Khayelitsha township ART programmes in Cape Town, South Africa.Cohorts of patients on ART monitored by POC-VL, CD4 cell count or clinically were simulated. Scenario A considered the more accurate detection of treatment failure with POC-VL only, and scenario B also considered the effect on HIV transmission. Scenario C further assumed that the risk of virologic failure is halved with POC-VL due to improved adherence. We estimated the change in costs per quality-adjusted life-year gained (incremental cost-effectiveness ratios, ICERs) of POC-VL compared with CD4 and clinical monitoring.POC-VL tests with detection limits less than 1000 copies/ml increased costs due to unnecessary switches to second-line ART, without improving survival. Assuming POC-VL unit costs between US$5 and US$20 and detection limits between 1000 and 10,000 copies/ml, the ICER of POC-VL was US$4010-US$9230 compared with clinical and US$5960-US$25540 compared with CD4 cell count monitoring. In Scenario B, the corresponding ICERs were US$2450-US$5830 and US$2230-US$10380. In Scenario C, the ICER ranged between US$960 and US$2500 compared with clinical monitoring and between cost-saving and US$2460 compared with CD4 monitoring.The cost-effectiveness of POC-VL for monitoring ART is improved by a higher detection limit, by taking the reduction in new HIV infections into account and assuming that failure of first-line ART is reduced due to targeted adherence counselling." @default.
• W2154937658 created "2016-06-24" @default.
• W2154937658 creator A5008028828 @default.
• W2154937658 creator A5011657274 @default.
• W2154937658 creator A5049874690 @default.
• W2154937658 creator A5051313787 @default.
• W2154937658 creator A5062110679 @default.
• W2154937658 creator A5064614188 @default.
• W2154937658 creator A5072701020 @default.
• W2154937658 creator A5077161809 @default.
• W2154937658 creator A5086318788 @default.
• W2154937658 date "2013-06-01" @default.
• W2154937658 modified "2023-10-17" @default.
• W2154937658 title "Cost-effectiveness of point-of-care viral load monitoring of antiretroviral therapy in resource-limited settings" @default.
• W2154937658 cites W1600314899 @default.
• W2154937658 cites W1972714070 @default.
• W2154937658 cites W1985790290 @default.
• W2154937658 cites W1991385165 @default.
• W2154937658 cites W1998515888 @default.
• W2154937658 cites W1998733860 @default.
• W2154937658 cites W2001017566 @default.
• W2154937658 cites W2028479418 @default.
• W2154937658 cites W2048706368 @default.
• W2154937658 cites W2053431870 @default.
• W2154937658 cites W2070629478 @default.
• W2154937658 cites W2101881758 @default.
• W2154937658 cites W2114267004 @default.
• W2154937658 cites W2120293408 @default.
• W2154937658 cites W2124801504 @default.
• W2154937658 cites W2126078440 @default.
• W2154937658 cites W2126279813 @default.
• W2154937658 cites W2128792719 @default.
• W2154937658 cites W2143079142 @default.
• W2154937658 cites W2144304933 @default.
• W2154937658 cites W2150369519 @default.
• W2154937658 cites W2156440755 @default.
• W2154937658 cites W2157981460 @default.
• W2154937658 cites W2158934536 @default.
• W2154937658 cites W2167155110 @default.
• W2154937658 cites W2168405519 @default.
• W2154937658 cites W2172106821 @default.
• W2154937658 cites W2308294549 @default.
• W2154937658 cites W2314461521 @default.
• W2154937658 doi "https://doi.org/10.1097/qad.0b013e328360a4e5" @default.
• W2154937658 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3813830" @default.
• W2154937658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23462219" @default.
• W2154937658 hasPublicationYear "2013" @default.
• W2154937658 type Work @default.
• W2154937658 sameAs 2154937658 @default.
• W2154937658 citedByCount "44" @default.
• W2154937658 countsByYear W21549376582013 @default.
• W2154937658 countsByYear W21549376582014 @default.
• W2154937658 countsByYear W21549376582015 @default.
• W2154937658 countsByYear W21549376582016 @default.
• W2154937658 countsByYear W21549376582017 @default.
• W2154937658 countsByYear W21549376582018 @default.
• W2154937658 countsByYear W21549376582019 @default.
• W2154937658 countsByYear W21549376582020 @default.
• W2154937658 countsByYear W21549376582021 @default.
• W2154937658 countsByYear W21549376582023 @default.
• W2154937658 crossrefType "journal-article" @default.
• W2154937658 hasAuthorship W2154937658A5008028828 @default.
• W2154937658 hasAuthorship W2154937658A5011657274 @default.
• W2154937658 hasAuthorship W2154937658A5049874690 @default.
• W2154937658 hasAuthorship W2154937658A5051313787 @default.
• W2154937658 hasAuthorship W2154937658A5062110679 @default.
• W2154937658 hasAuthorship W2154937658A5064614188 @default.
• W2154937658 hasAuthorship W2154937658A5072701020 @default.
• W2154937658 hasAuthorship W2154937658A5077161809 @default.
• W2154937658 hasAuthorship W2154937658A5086318788 @default.
• W2154937658 hasBestOaLocation W21549376581 @default.
• W2154937658 hasConcept C112930515 @default.
• W2154937658 hasConcept C142462285 @default.
• W2154937658 hasConcept C142724271 @default.
• W2154937658 hasConcept C159047783 @default.
• W2154937658 hasConcept C194828623 @default.
• W2154937658 hasConcept C2993143319 @default.
• W2154937658 hasConcept C3013748606 @default.
• W2154937658 hasConcept C3019080777 @default.
• W2154937658 hasConcept C51915194 @default.
• W2154937658 hasConcept C71924100 @default.
• W2154937658 hasConceptScore W2154937658C112930515 @default.
• W2154937658 hasConceptScore W2154937658C142462285 @default.
• W2154937658 hasConceptScore W2154937658C142724271 @default.
• W2154937658 hasConceptScore W2154937658C159047783 @default.
• W2154937658 hasConceptScore W2154937658C194828623 @default.
• W2154937658 hasConceptScore W2154937658C2993143319 @default.
• W2154937658 hasConceptScore W2154937658C3013748606 @default.
• W2154937658 hasConceptScore W2154937658C3019080777 @default.
• W2154937658 hasConceptScore W2154937658C51915194 @default.
• W2154937658 hasConceptScore W2154937658C71924100 @default.
• W2154937658 hasIssue "9" @default.
• W2154937658 hasLocation W21549376581 @default.
• W2154937658 hasLocation W21549376582 @default.
• W2154937658 hasLocation W21549376583 @default.
• W2154937658 hasLocation W21549376584 @default.
• W2154937658 hasLocation W21549376585 @default.
• W2154937658 hasOpenAccess W2154937658 @default.

• next