Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154960189> ?p ?o ?g. }
- W2154960189 endingPage "e1003771" @default.
- W2154960189 startingPage "e1003771" @default.
- W2154960189 abstract "Approximately one-third of the world's population suffers from chronic helminth infections with no effective vaccines currently available. Antibodies and alternatively activated macrophages (AAM) form crucial components of protective immunity against challenge infections with intestinal helminths. However, the mechanisms by which antibodies target these large multi-cellular parasites remain obscure. Alternative activation of macrophages during helminth infection has been linked to signaling through the IL-4 receptor alpha chain (IL-4Rα), but the potential effects of antibodies on macrophage differentiation have not been explored. We demonstrate that helminth-specific antibodies induce the rapid trapping of tissue migrating helminth larvae and prevent tissue necrosis following challenge infection with the natural murine parasite Heligmosomoides polygyrus bakeri (Hp). Mice lacking antibodies (JH (-/-)) or activating Fc receptors (FcRγ(-/-)) harbored highly motile larvae, developed extensive tissue damage and accumulated less Arginase-1 expressing macrophages around the larvae. Moreover, Hp-specific antibodies induced FcRγ- and complement-dependent adherence of macrophages to larvae in vitro, resulting in complete larval immobilization. Antibodies together with helminth larvae reprogrammed macrophages to express wound-healing associated genes, including Arginase-1, and the Arginase-1 product L-ornithine directly impaired larval motility. Antibody-induced expression of Arginase-1 in vitro and in vivo occurred independently of IL-4Rα signaling. In summary, we present a novel IL-4Rα-independent mechanism of alternative macrophage activation that is antibody-dependent and which both mediates anti-helminth immunity and prevents tissue disruption caused by migrating larvae." @default.
- W2154960189 created "2016-06-24" @default.
- W2154960189 creator A5005956071 @default.
- W2154960189 creator A5009701458 @default.
- W2154960189 creator A5011615487 @default.
- W2154960189 creator A5018782848 @default.
- W2154960189 creator A5046864809 @default.
- W2154960189 creator A5052079654 @default.
- W2154960189 creator A5053936942 @default.
- W2154960189 creator A5075887952 @default.
- W2154960189 creator A5084557532 @default.
- W2154960189 creator A5089701275 @default.
- W2154960189 date "2013-11-14" @default.
- W2154960189 modified "2023-10-17" @default.
- W2154960189 title "Antibodies Trap Tissue Migrating Helminth Larvae and Prevent Tissue Damage by Driving IL-4Rα-Independent Alternative Differentiation of Macrophages" @default.
- W2154960189 cites W147011734 @default.
- W2154960189 cites W1519149544 @default.
- W2154960189 cites W1526905466 @default.
- W2154960189 cites W1571914910 @default.
- W2154960189 cites W1594300813 @default.
- W2154960189 cites W1600880529 @default.
- W2154960189 cites W1601476460 @default.
- W2154960189 cites W1700538518 @default.
- W2154960189 cites W1884645714 @default.
- W2154960189 cites W1900802472 @default.
- W2154960189 cites W1966752763 @default.
- W2154960189 cites W1967194148 @default.
- W2154960189 cites W1968254266 @default.
- W2154960189 cites W1968832176 @default.
- W2154960189 cites W1968884620 @default.
- W2154960189 cites W1970555542 @default.
- W2154960189 cites W1972108403 @default.
- W2154960189 cites W1976026840 @default.
- W2154960189 cites W1978878058 @default.
- W2154960189 cites W1983378719 @default.
- W2154960189 cites W1984765229 @default.
- W2154960189 cites W1985859986 @default.
- W2154960189 cites W1991082344 @default.
- W2154960189 cites W1991674225 @default.
- W2154960189 cites W1993913999 @default.
- W2154960189 cites W1994718754 @default.
- W2154960189 cites W1994928831 @default.
- W2154960189 cites W1995299599 @default.
- W2154960189 cites W1996737480 @default.
- W2154960189 cites W2003084688 @default.
- W2154960189 cites W2003590292 @default.
- W2154960189 cites W2007949618 @default.
- W2154960189 cites W2008214282 @default.
- W2154960189 cites W2013705418 @default.
- W2154960189 cites W2018046042 @default.
- W2154960189 cites W2033285123 @default.
- W2154960189 cites W2034458870 @default.
- W2154960189 cites W2035964694 @default.
- W2154960189 cites W2036066215 @default.
- W2154960189 cites W2038461328 @default.
- W2154960189 cites W2038689279 @default.
- W2154960189 cites W2042770844 @default.
- W2154960189 cites W2044678751 @default.
- W2154960189 cites W2045628444 @default.
- W2154960189 cites W2055348159 @default.
- W2154960189 cites W2059081392 @default.
- W2154960189 cites W2062767382 @default.
- W2154960189 cites W2076971074 @default.
- W2154960189 cites W2077702220 @default.
- W2154960189 cites W2086141133 @default.
- W2154960189 cites W2097549854 @default.
- W2154960189 cites W2099013529 @default.
- W2154960189 cites W2100869499 @default.
- W2154960189 cites W2102201378 @default.
- W2154960189 cites W2108350582 @default.
- W2154960189 cites W2111599442 @default.
- W2154960189 cites W2111811965 @default.
- W2154960189 cites W2112384663 @default.
- W2154960189 cites W2115545988 @default.
- W2154960189 cites W2115993724 @default.
- W2154960189 cites W2119817843 @default.
- W2154960189 cites W2124700037 @default.
- W2154960189 cites W2124806393 @default.
- W2154960189 cites W2124988062 @default.
- W2154960189 cites W2125735974 @default.
- W2154960189 cites W2128079521 @default.
- W2154960189 cites W2129431737 @default.
- W2154960189 cites W2131103018 @default.
- W2154960189 cites W2136415390 @default.
- W2154960189 cites W2136597137 @default.
- W2154960189 cites W2137425057 @default.
- W2154960189 cites W2139198961 @default.
- W2154960189 cites W2139420317 @default.
- W2154960189 cites W2142832537 @default.
- W2154960189 cites W2147307935 @default.
- W2154960189 cites W2149698238 @default.
- W2154960189 cites W2155627576 @default.
- W2154960189 cites W2158869405 @default.
- W2154960189 cites W2160097418 @default.
- W2154960189 cites W2161293512 @default.
- W2154960189 cites W2164588772 @default.
- W2154960189 cites W2168203604 @default.
- W2154960189 cites W2169142991 @default.