FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154964951> ?p ?o ?g. }

• W2154964951 endingPage "42" @default.
• W2154964951 startingPage "6236" @default.
• W2154964951 abstract "Gene silencing associated with aberrant methylation of promoter region CpG islands is an acquired epigenetic alteration that serves as an alternative to genetic defects in the inactivation of tumor suppressor and other genes in human cancers. The hypothesis that aberrant methylation plays a direct causal role in carcinogenesis hinges on the question of whether aberrant methylation is sufficient to drive gene silencing. To identify downstream targets of methylation-induced gene silencing, we used a human cell model in which aberrant CpG island methylation is induced by ectopic expression of DNA methyltransferase. Here we report the isolation and characterization of TMS1 (target of methylation-induced silencing), a novel CpG island-associated gene that becomes hypermethylated and silenced in cells overexpressing DNA cytosine-5-methyltransferase-1. We also show that TMS1 is aberrantly methylated and silenced in human breast cancer cells. Forty percent (11 of 27) of primary breast tumors exhibited aberrant methylation of TMS1. TMS1 is localized to chromosome 16p11.2-12.1 and encodes a 22-kDa predicted protein containing a COOH-terminal caspase recruitment domain, a recently described protein interaction motif found in apoptotic signaling molecules. Ectopic expression of TMS1 induced apoptosis in 293 cells and inhibited the survival of human breast cancer cells. The data suggest that methylation-mediated silencing of TMS1 confers a survival advantage by allowing cells to escape from apoptosis, supporting a new role for aberrant methylation in breast tumorigenesis." @default.
• W2154964951 created "2016-06-24" @default.
• W2154964951 creator A5006618228 @default.
• W2154964951 creator A5015912504 @default.
• W2154964951 creator A5017447734 @default.
• W2154964951 creator A5023914766 @default.
• W2154964951 creator A5024242252 @default.
• W2154964951 creator A5091014475 @default.
• W2154964951 date "2000-11-15" @default.
• W2154964951 modified "2023-09-27" @default.
• W2154964951 title "TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers." @default.
• W2154964951 cites W115055913 @default.
• W2154964951 cites W1484293540 @default.
• W2154964951 cites W1486257535 @default.
• W2154964951 cites W1493702629 @default.
• W2154964951 cites W1520695706 @default.
• W2154964951 cites W1533247917 @default.
• W2154964951 cites W1533942477 @default.
• W2154964951 cites W1552528612 @default.
• W2154964951 cites W1556996865 @default.
• W2154964951 cites W1563487810 @default.
• W2154964951 cites W1567517848 @default.
• W2154964951 cites W1573146315 @default.
• W2154964951 cites W1578821331 @default.
• W2154964951 cites W1784857457 @default.
• W2154964951 cites W1975870295 @default.
• W2154964951 cites W1977922844 @default.
• W2154964951 cites W1981226387 @default.
• W2154964951 cites W1990735654 @default.
• W2154964951 cites W1994465394 @default.
• W2154964951 cites W2006338784 @default.
• W2154964951 cites W2013050589 @default.
• W2154964951 cites W2019432938 @default.
• W2154964951 cites W2024527294 @default.
• W2154964951 cites W2027590165 @default.
• W2154964951 cites W2080821826 @default.
• W2154964951 cites W2084118479 @default.
• W2154964951 cites W2085006185 @default.
• W2154964951 cites W2091658754 @default.
• W2154964951 cites W2100143432 @default.
• W2154964951 cites W2107972234 @default.
• W2154964951 cites W2117661585 @default.
• W2154964951 cites W2118026853 @default.
• W2154964951 cites W2119502087 @default.
• W2154964951 cites W2121585544 @default.
• W2154964951 cites W2122116522 @default.
• W2154964951 cites W2126422047 @default.
• W2154964951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11103776" @default.
• W2154964951 hasPublicationYear "2000" @default.
• W2154964951 type Work @default.
• W2154964951 sameAs 2154964951 @default.
• W2154964951 citedByCount "91" @default.
• W2154964951 countsByYear W21549649512013 @default.
• W2154964951 countsByYear W21549649512014 @default.
• W2154964951 countsByYear W21549649512015 @default.
• W2154964951 countsByYear W21549649512016 @default.
• W2154964951 countsByYear W21549649512017 @default.
• W2154964951 countsByYear W21549649512019 @default.
• W2154964951 countsByYear W21549649512020 @default.
• W2154964951 countsByYear W21549649512021 @default.
• W2154964951 countsByYear W21549649512022 @default.
• W2154964951 countsByYear W21549649512023 @default.
• W2154964951 crossrefType "journal-article" @default.
• W2154964951 hasAuthorship W2154964951A5006618228 @default.
• W2154964951 hasAuthorship W2154964951A5015912504 @default.
• W2154964951 hasAuthorship W2154964951A5017447734 @default.
• W2154964951 hasAuthorship W2154964951A5023914766 @default.
• W2154964951 hasAuthorship W2154964951A5024242252 @default.
• W2154964951 hasAuthorship W2154964951A5091014475 @default.
• W2154964951 hasConcept C104317684 @default.
• W2154964951 hasConcept C119056186 @default.
• W2154964951 hasConcept C140173407 @default.
• W2154964951 hasConcept C150194340 @default.
• W2154964951 hasConcept C153911025 @default.
• W2154964951 hasConcept C190727270 @default.
• W2154964951 hasConcept C33288867 @default.
• W2154964951 hasConcept C41091548 @default.
• W2154964951 hasConcept C502942594 @default.
• W2154964951 hasConcept C54355233 @default.
• W2154964951 hasConcept C555283112 @default.
• W2154964951 hasConcept C86803240 @default.
• W2154964951 hasConcept C97037327 @default.
• W2154964951 hasConceptScore W2154964951C104317684 @default.
• W2154964951 hasConceptScore W2154964951C119056186 @default.
• W2154964951 hasConceptScore W2154964951C140173407 @default.
• W2154964951 hasConceptScore W2154964951C150194340 @default.
• W2154964951 hasConceptScore W2154964951C153911025 @default.
• W2154964951 hasConceptScore W2154964951C190727270 @default.
• W2154964951 hasConceptScore W2154964951C33288867 @default.
• W2154964951 hasConceptScore W2154964951C41091548 @default.
• W2154964951 hasConceptScore W2154964951C502942594 @default.
• W2154964951 hasConceptScore W2154964951C54355233 @default.
• W2154964951 hasConceptScore W2154964951C555283112 @default.
• W2154964951 hasConceptScore W2154964951C86803240 @default.
• W2154964951 hasConceptScore W2154964951C97037327 @default.
• W2154964951 hasIssue "22" @default.
• W2154964951 hasLocation W21549649511 @default.
• W2154964951 hasOpenAccess W2154964951 @default.

• next