FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154966612> ?p ?o ?g. }

• W2154966612 endingPage "3267" @default.
• W2154966612 startingPage "3254" @default.
• W2154966612 abstract "It is recognized that host response following viral infection is characterized by immunodominance, but deciphering the different factors contributing to immunodominance has proved a challenge due to concurrent expression of multiple MHC class I alleles. To address this, we generated H2-K−/−/D−/− double-knockout transgenic mice expressing either one or two human MHC-I alleles. We hypothesized that co-expression of different allele combinations figures critically in immunodominance and examined this in influenza-infected, double Tg MHC-I mice. In A2/B7 or A2/B27 mice, using ELISpot assays with the A2-restricted matrix I.58–66, the B7-restricted NP418–426 or the B27-restricted NP383–391 influenza A (flu) epitopes, we observed the expected recognition of both peptides for both alleles. In contrast, in flu-infected B7/B27 mice, a significantly reduced level of B27/NP383-restricted CTL response was detected while there was no change in the B7/NP418-restricted CTL response. Flu-specific tetramer studies revealed a partial deletion of Vβ8.1+ NP383/B27-restricted CD8+ T cells, and a diminished Vβ12+ CD8+ T-cell expansion in B7/B27 Tg mice. Using HLA Tg chimeric mice, we confirmed these findings. These findings shed light on the immune consequences of co-dominant expression of MHC-I alleles for host immune response to pathogens." @default.
• W2154966612 created "2016-06-24" @default.
• W2154966612 creator A5028232629 @default.
• W2154966612 creator A5038121079 @default.
• W2154966612 date "2013-10-20" @default.
• W2154966612 modified "2023-09-27" @default.
• W2154966612 title "Co-expression of HLA-B7 and HLA-B27 alleles is associated with B7-restricted immunodominant responses following influenza infection" @default.
• W2154966612 cites W1481208898 @default.
• W2154966612 cites W1502370146 @default.
• W2154966612 cites W1540853787 @default.
• W2154966612 cites W1641493467 @default.
• W2154966612 cites W1800855145 @default.
• W2154966612 cites W1809576401 @default.
• W2154966612 cites W1928008970 @default.
• W2154966612 cites W1978264222 @default.
• W2154966612 cites W1998036341 @default.
• W2154966612 cites W2002429449 @default.
• W2154966612 cites W2006200047 @default.
• W2154966612 cites W2018316453 @default.
• W2154966612 cites W2023038954 @default.
• W2154966612 cites W2024925506 @default.
• W2154966612 cites W2027434623 @default.
• W2154966612 cites W2034376866 @default.
• W2154966612 cites W2040967079 @default.
• W2154966612 cites W2043837317 @default.
• W2154966612 cites W2045209342 @default.
• W2154966612 cites W2062995065 @default.
• W2154966612 cites W2074035251 @default.
• W2154966612 cites W2077466422 @default.
• W2154966612 cites W2081291846 @default.
• W2154966612 cites W2083779678 @default.
• W2154966612 cites W2085871918 @default.
• W2154966612 cites W2086274485 @default.
• W2154966612 cites W2092998218 @default.
• W2154966612 cites W2097398162 @default.
• W2154966612 cites W2104148360 @default.
• W2154966612 cites W2123800980 @default.
• W2154966612 cites W2137451029 @default.
• W2154966612 cites W2150230456 @default.
• W2154966612 cites W2154026406 @default.
• W2154966612 cites W2166087046 @default.
• W2154966612 cites W2168274979 @default.
• W2154966612 cites W2169279776 @default.
• W2154966612 cites W2169905609 @default.
• W2154966612 cites W2183601798 @default.
• W2154966612 doi "https://doi.org/10.1002/eji.201343597" @default.
• W2154966612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24113999" @default.
• W2154966612 hasPublicationYear "2013" @default.
• W2154966612 type Work @default.
• W2154966612 sameAs 2154966612 @default.
• W2154966612 citedByCount "15" @default.
• W2154966612 countsByYear W21549666122014 @default.
• W2154966612 countsByYear W21549666122015 @default.
• W2154966612 countsByYear W21549666122016 @default.
• W2154966612 countsByYear W21549666122017 @default.
• W2154966612 countsByYear W21549666122021 @default.
• W2154966612 countsByYear W21549666122022 @default.
• W2154966612 crossrefType "journal-article" @default.
• W2154966612 hasAuthorship W2154966612A5028232629 @default.
• W2154966612 hasAuthorship W2154966612A5038121079 @default.
• W2154966612 hasConcept C104317684 @default.
• W2154966612 hasConcept C147483822 @default.
• W2154966612 hasConcept C147969180 @default.
• W2154966612 hasConcept C159047783 @default.
• W2154966612 hasConcept C167672396 @default.
• W2154966612 hasConcept C180754005 @default.
• W2154966612 hasConcept C195616568 @default.
• W2154966612 hasConcept C203014093 @default.
• W2154966612 hasConcept C207936829 @default.
• W2154966612 hasConcept C2776525413 @default.
• W2154966612 hasConcept C54355233 @default.
• W2154966612 hasConcept C86803240 @default.
• W2154966612 hasConcept C8891405 @default.
• W2154966612 hasConceptScore W2154966612C104317684 @default.
• W2154966612 hasConceptScore W2154966612C147483822 @default.
• W2154966612 hasConceptScore W2154966612C147969180 @default.
• W2154966612 hasConceptScore W2154966612C159047783 @default.
• W2154966612 hasConceptScore W2154966612C167672396 @default.
• W2154966612 hasConceptScore W2154966612C180754005 @default.
• W2154966612 hasConceptScore W2154966612C195616568 @default.
• W2154966612 hasConceptScore W2154966612C203014093 @default.
• W2154966612 hasConceptScore W2154966612C207936829 @default.
• W2154966612 hasConceptScore W2154966612C2776525413 @default.
• W2154966612 hasConceptScore W2154966612C54355233 @default.
• W2154966612 hasConceptScore W2154966612C86803240 @default.
• W2154966612 hasConceptScore W2154966612C8891405 @default.
• W2154966612 hasIssue "12" @default.
• W2154966612 hasLocation W21549666121 @default.
• W2154966612 hasLocation W21549666122 @default.
• W2154966612 hasOpenAccess W2154966612 @default.
• W2154966612 hasPrimaryLocation W21549666121 @default.
• W2154966612 hasRelatedWork W1966175722 @default.
• W2154966612 hasRelatedWork W1988201115 @default.
• W2154966612 hasRelatedWork W2026564383 @default.
• W2154966612 hasRelatedWork W2067458140 @default.
• W2154966612 hasRelatedWork W2099296320 @default.
• W2154966612 hasRelatedWork W2101588130 @default.
• W2154966612 hasRelatedWork W2123096807 @default.

• next