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- W2154970061 abstract "ABSTRACT The opportunistic pathogen Pseudomonas aeruginosa produces colorful, redox-active antibiotics called phenazines. Excretion of pyocyanin, the best-studied natural phenazine, is responsible for the bluish tint of sputum and pus associated with P. aeruginosa infections in humans. Although the toxicity of pyocyanin for other bacteria, as well as its role in eukaryotic infection, has been studied extensively, the physiological relevance of pyocyanin metabolism for the producing organism is not well understood. Pyocyanin reduction by P. aeruginosa PA14 is readily observed in standing liquid cultures that have consumed all of the oxygen in the medium. We investigated the physiological consequences of pyocyanin reduction by assaying intracellular concentrations of NADH and NAD + in the wild-type strain and a mutant defective in phenazine production. We found that the mutant accumulated more NADH in stationary phase than the wild type. This increased accumulation correlated with a decrease in oxygen availability and was relieved by the addition of nitrate. Pyocyanin addition to a phenazine-null mutant also decreased intracellular NADH levels, suggesting that pyocyanin reduction facilitates redox balancing in the absence of other electron acceptors. Analysis of extracellular organic acids revealed that pyocyanin stimulated stationary-phase pyruvate excretion in P. aeruginosa PA14, indicating that pyocyanin may also influence the intracellular redox state by decreasing carbon flux through central metabolic pathways." @default.
- W2154970061 created "2016-06-24" @default.
- W2154970061 creator A5037368334 @default.
- W2154970061 creator A5064094344 @default.
- W2154970061 creator A5065958736 @default.
- W2154970061 date "2007-09-01" @default.
- W2154970061 modified "2023-10-06" @default.
- W2154970061 title "Pyocyanin Alters Redox Homeostasis and Carbon Flux through Central Metabolic Pathways in <i>Pseudomonas aeruginosa</i> PA14" @default.
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- W2154970061 doi "https://doi.org/10.1128/jb.00505-07" @default.
- W2154970061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1951912" @default.
- W2154970061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17526704" @default.
- W2154970061 hasPublicationYear "2007" @default.
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