FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154975675> ?p ?o ?g. }

• W2154975675 abstract "Intersectin is a member of a growing family of adaptor proteins that possess conserved Eps15 homology (EH) domains as well as additional protein recognition motifs. In general, EH domain-containing proteins play an integral role in clathrin-mediated endocytosis. Indeed, intersectin functions in the intermediate stages of clathrin-coated vesicle assembly. However, recent evidence suggests that components of the endocytic machinery also regulate mitogenic signaling pathways. In this report, we provide several lines of evidence that intersectin has the capacity to activate mitogenic signaling pathways. First, intersectin overexpression activated the Elk-1 transcription factor in an MAPK-independent manner. This ability resides within the EH domains, as expression of the tandem EH domains was sufficient to activate Elk-1. Second, intersectin cooperated with epidermal growth factor to potentiate Elk-1 activation; however, a similar level of Elk-1 activation was obtained by expression of the tandem EH domains suggesting that the coiled-coil region and SH3 domains act to regulate the EH domains. Third, intersectin expression was sufficient to induce oncogenic transformation of rodent fibroblasts. And finally, intersectin cooperated with progesterone to accelerate maturation of Xenopus laevis oocytes. Together, these data suggest that intersectin links endocytosis with regulation of pathways important for cell growth and differentiation." @default.
• W2154975675 created "2016-06-24" @default.
• W2154975675 creator A5019046184 @default.
• W2154975675 creator A5026673175 @default.
• W2154975675 creator A5074291852 @default.
• W2154975675 creator A5084266690 @default.
• W2154975675 creator A5091122273 @default.
• W2154975675 date "2000-06-12" @default.
• W2154975675 modified "2023-10-17" @default.
• W2154975675 title "Intersectin, an adaptor protein involved in clathrin-mediated endocytosis, activates mitogenic signaling pathways" @default.
• W2154975675 cites W1508658015 @default.
• W2154975675 cites W1547066932 @default.
• W2154975675 cites W1548893012 @default.
• W2154975675 cites W1550712876 @default.
• W2154975675 cites W1915945057 @default.
• W2154975675 cites W1930849747 @default.
• W2154975675 cites W1963817582 @default.
• W2154975675 cites W1971746394 @default.
• W2154975675 cites W1972377722 @default.
• W2154975675 cites W1979171720 @default.
• W2154975675 cites W1982186905 @default.
• W2154975675 cites W1984269514 @default.
• W2154975675 cites W1984536659 @default.
• W2154975675 cites W1984751884 @default.
• W2154975675 cites W1986248861 @default.
• W2154975675 cites W2011761299 @default.
• W2154975675 cites W2012021856 @default.
• W2154975675 cites W2021939146 @default.
• W2154975675 cites W2032554631 @default.
• W2154975675 cites W2032923234 @default.
• W2154975675 cites W2038905197 @default.
• W2154975675 cites W2045499828 @default.
• W2154975675 cites W2048784760 @default.
• W2154975675 cites W2056701485 @default.
• W2154975675 cites W2086262311 @default.
• W2154975675 cites W2099729324 @default.
• W2154975675 cites W2113343108 @default.
• W2154975675 cites W2118141440 @default.
• W2154975675 cites W2118211098 @default.
• W2154975675 cites W2120328091 @default.
• W2154975675 cites W2125144482 @default.
• W2154975675 cites W2126868012 @default.
• W2154975675 cites W2136831156 @default.
• W2154975675 cites W2143975798 @default.
• W2154975675 cites W2152741987 @default.
• W2154975675 cites W2154042872 @default.
• W2154975675 cites W2154335145 @default.
• W2154975675 cites W2163199165 @default.
• W2154975675 cites W2170906235 @default.
• W2154975675 cites W2281113432 @default.
• W2154975675 cites W2414472146 @default.
• W2154975675 doi "https://doi.org/10.1074/jbc.m004810200" @default.
• W2154975675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10851244" @default.
• W2154975675 hasPublicationYear "2000" @default.
• W2154975675 type Work @default.
• W2154975675 sameAs 2154975675 @default.
• W2154975675 citedByCount "33" @default.
• W2154975675 countsByYear W21549756752012 @default.
• W2154975675 countsByYear W21549756752015 @default.
• W2154975675 countsByYear W21549756752016 @default.
• W2154975675 countsByYear W21549756752017 @default.
• W2154975675 countsByYear W21549756752018 @default.
• W2154975675 countsByYear W21549756752019 @default.
• W2154975675 countsByYear W21549756752020 @default.
• W2154975675 countsByYear W21549756752021 @default.
• W2154975675 countsByYear W21549756752022 @default.
• W2154975675 countsByYear W21549756752023 @default.
• W2154975675 crossrefType "journal-article" @default.
• W2154975675 hasAuthorship W2154975675A5019046184 @default.
• W2154975675 hasAuthorship W2154975675A5026673175 @default.
• W2154975675 hasAuthorship W2154975675A5074291852 @default.
• W2154975675 hasAuthorship W2154975675A5084266690 @default.
• W2154975675 hasAuthorship W2154975675A5091122273 @default.
• W2154975675 hasBestOaLocation W21549756751 @default.
• W2154975675 hasConcept C170493617 @default.
• W2154975675 hasConcept C183786373 @default.
• W2154975675 hasConcept C185592680 @default.
• W2154975675 hasConcept C28005876 @default.
• W2154975675 hasConcept C55493867 @default.
• W2154975675 hasConcept C62478195 @default.
• W2154975675 hasConcept C63162447 @default.
• W2154975675 hasConcept C86803240 @default.
• W2154975675 hasConcept C95444343 @default.
• W2154975675 hasConceptScore W2154975675C170493617 @default.
• W2154975675 hasConceptScore W2154975675C183786373 @default.
• W2154975675 hasConceptScore W2154975675C185592680 @default.
• W2154975675 hasConceptScore W2154975675C28005876 @default.
• W2154975675 hasConceptScore W2154975675C55493867 @default.
• W2154975675 hasConceptScore W2154975675C62478195 @default.
• W2154975675 hasConceptScore W2154975675C63162447 @default.
• W2154975675 hasConceptScore W2154975675C86803240 @default.
• W2154975675 hasConceptScore W2154975675C95444343 @default.
• W2154975675 hasLocation W21549756751 @default.
• W2154975675 hasOpenAccess W2154975675 @default.
• W2154975675 hasPrimaryLocation W21549756751 @default.
• W2154975675 hasRelatedWork W2010696236 @default.
• W2154975675 hasRelatedWork W2047876133 @default.
• W2154975675 hasRelatedWork W2070297191 @default.
• W2154975675 hasRelatedWork W2096443169 @default.
• W2154975675 hasRelatedWork W2114854758 @default.

• next