Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154992599> ?p ?o ?g. }
- W2154992599 endingPage "810" @default.
- W2154992599 startingPage "803" @default.
- W2154992599 abstract "Successive activation of Wnt4 and Notch2 generates nephrons from the metanephric mesenchyme. Mesenchymal-to-epithelial transition requires Wnt4, and normal development of the proximal nephron (epithelia of glomeruli and proximal tubules) requires Notch2. It is unknown, however, whether Notch2 dictates the fate of the proximal nephron directly. Here, we generated a mutant strain of mice with activated Notch2 in Six2-containing nephron progenitor cells of the metanephric mesenchyme. Notch2 activation did not skew the cell fate toward the proximal nephron but resulted in severe kidney dysgenesis and depletion of Six2-positive progenitors. We observed ectopic expression of Wnt4 and premature tubule formation, similar to the phenotype of Six2-deficient mice. Activation of Notch2 in the progenitor cells suppressed Pax2, an upstream regulator of Six2, possibly through Hesr genes. Taken together, these data suggest that a positive feedback loop exists between Notch2 and Wnt4, and that Notch2 stabilizes, rather than dictates, nephron fate by shutting down the maintenance of undifferentiated progenitor cells, thereby depleting this population." @default.
- W2154992599 created "2016-06-24" @default.
- W2154992599 creator A5027541838 @default.
- W2154992599 creator A5035560491 @default.
- W2154992599 creator A5052403672 @default.
- W2154992599 creator A5054567757 @default.
- W2154992599 date "2010-05-01" @default.
- W2154992599 modified "2023-10-18" @default.
- W2154992599 title "Notch2 Activation in the Embryonic Kidney Depletes Nephron Progenitors" @default.
- W2154992599 cites W1768274470 @default.
- W2154992599 cites W1802426888 @default.
- W2154992599 cites W1971689970 @default.
- W2154992599 cites W1980020302 @default.
- W2154992599 cites W1991148912 @default.
- W2154992599 cites W1994610109 @default.
- W2154992599 cites W2012409410 @default.
- W2154992599 cites W2017438223 @default.
- W2154992599 cites W2027322371 @default.
- W2154992599 cites W2042534735 @default.
- W2154992599 cites W2050627146 @default.
- W2154992599 cites W2051998916 @default.
- W2154992599 cites W2053841715 @default.
- W2154992599 cites W2066484100 @default.
- W2154992599 cites W2075993202 @default.
- W2154992599 cites W2082584428 @default.
- W2154992599 cites W2083356835 @default.
- W2154992599 cites W2084585178 @default.
- W2154992599 cites W2092920480 @default.
- W2154992599 cites W2098272219 @default.
- W2154992599 cites W2103313183 @default.
- W2154992599 cites W2105361659 @default.
- W2154992599 cites W2106069796 @default.
- W2154992599 cites W2109627278 @default.
- W2154992599 cites W2122329737 @default.
- W2154992599 cites W2124852687 @default.
- W2154992599 cites W2129828870 @default.
- W2154992599 cites W2135061086 @default.
- W2154992599 cites W2137504683 @default.
- W2154992599 cites W2140554702 @default.
- W2154992599 cites W2142472665 @default.
- W2154992599 cites W2145111609 @default.
- W2154992599 cites W2145832243 @default.
- W2154992599 cites W2151646137 @default.
- W2154992599 cites W2164419770 @default.
- W2154992599 cites W2406782863 @default.
- W2154992599 doi "https://doi.org/10.1681/asn.2009040353" @default.
- W2154992599 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2865736" @default.
- W2154992599 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20299358" @default.
- W2154992599 hasPublicationYear "2010" @default.
- W2154992599 type Work @default.
- W2154992599 sameAs 2154992599 @default.
- W2154992599 citedByCount "65" @default.
- W2154992599 countsByYear W21549925992012 @default.
- W2154992599 countsByYear W21549925992013 @default.
- W2154992599 countsByYear W21549925992014 @default.
- W2154992599 countsByYear W21549925992015 @default.
- W2154992599 countsByYear W21549925992016 @default.
- W2154992599 countsByYear W21549925992017 @default.
- W2154992599 countsByYear W21549925992018 @default.
- W2154992599 countsByYear W21549925992019 @default.
- W2154992599 countsByYear W21549925992020 @default.
- W2154992599 countsByYear W21549925992021 @default.
- W2154992599 countsByYear W21549925992022 @default.
- W2154992599 countsByYear W21549925992023 @default.
- W2154992599 crossrefType "journal-article" @default.
- W2154992599 hasAuthorship W2154992599A5027541838 @default.
- W2154992599 hasAuthorship W2154992599A5035560491 @default.
- W2154992599 hasAuthorship W2154992599A5052403672 @default.
- W2154992599 hasAuthorship W2154992599A5054567757 @default.
- W2154992599 hasBestOaLocation W21549925991 @default.
- W2154992599 hasConcept C104317684 @default.
- W2154992599 hasConcept C126322002 @default.
- W2154992599 hasConcept C129536746 @default.
- W2154992599 hasConcept C134018914 @default.
- W2154992599 hasConcept C137620995 @default.
- W2154992599 hasConcept C145103041 @default.
- W2154992599 hasConcept C15729860 @default.
- W2154992599 hasConcept C163952510 @default.
- W2154992599 hasConcept C182928434 @default.
- W2154992599 hasConcept C196843134 @default.
- W2154992599 hasConcept C198826908 @default.
- W2154992599 hasConcept C201750760 @default.
- W2154992599 hasConcept C2776340970 @default.
- W2154992599 hasConcept C2777632694 @default.
- W2154992599 hasConcept C2780091579 @default.
- W2154992599 hasConcept C2780915607 @default.
- W2154992599 hasConcept C2781231759 @default.
- W2154992599 hasConcept C2781430442 @default.
- W2154992599 hasConcept C28328180 @default.
- W2154992599 hasConcept C2908647359 @default.
- W2154992599 hasConcept C54355233 @default.
- W2154992599 hasConcept C62478195 @default.
- W2154992599 hasConcept C63101894 @default.
- W2154992599 hasConcept C71924100 @default.
- W2154992599 hasConcept C86339819 @default.
- W2154992599 hasConcept C86803240 @default.
- W2154992599 hasConcept C87073359 @default.
- W2154992599 hasConcept C95444343 @default.