Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155011421> ?p ?o ?g. }
- W2155011421 endingPage "1288" @default.
- W2155011421 startingPage "1279" @default.
- W2155011421 abstract "Dendritic cells (DCs) are essential for the early events of human immunodeficiency virus (HIV) infection. Model systems of HIV sexual transmission have shown that DCs expressing the DC-specific C-type lectin DC-SIGN capture and internalize HIV at mucosal surfaces and efficiently transfer HIV to CD4+ T cells in lymph nodes, where viral replication occurs. Upon DC-T cell clustering, internalized HIV accumulates on the DC side at the contact zone (infectious synapse), between DCs and T cells, whereas HIV receptors and coreceptors are enriched on the T cell side. Viral concentration at the infectious synapse may explain, at least in part, why DC transmission of HIV to T cells is so efficient.Here, we have investigated the role of DC-SIGN on primary DCs in X4 HIV-1 capture and transmission using small interfering RNA-expressing lentiviral vectors to specifically knockdown DC-SIGN. We demonstrate that DC-SIGN- DCs internalize X4 HIV-1 as well as DC-SIGN+ DCs, although binding of virions is reduced. Strikingly, DC-SIGN knockdown in DCs selectively impairs infectious synapse formation between DCs and resting CD4+ T cells, but does not prevent the formation of DC-T cells conjugates. Our results demonstrate that DC-SIGN is required downstream from viral capture for the formation of the infectious synapse between DCs and T cells. These findings provide a novel explanation for the role of DC-SIGN in the transfer and enhancement of HIV infection from DCs to T cells, a crucial step for HIV transmission and pathogenesis." @default.
- W2155011421 created "2016-06-24" @default.
- W2155011421 creator A5009217310 @default.
- W2155011421 creator A5013057077 @default.
- W2155011421 creator A5019884656 @default.
- W2155011421 creator A5028948869 @default.
- W2155011421 creator A5040469370 @default.
- W2155011421 creator A5054910534 @default.
- W2155011421 creator A5062312342 @default.
- W2155011421 date "2004-11-15" @default.
- W2155011421 modified "2023-10-07" @default.
- W2155011421 title "DC-SIGN–mediated Infectious Synapse Formation Enhances X4 HIV-1 Transmission from Dendritic Cells to T Cells" @default.
- W2155011421 cites W145413137 @default.
- W2155011421 cites W1500168279 @default.
- W2155011421 cites W1518539840 @default.
- W2155011421 cites W1521203309 @default.
- W2155011421 cites W1524602398 @default.
- W2155011421 cites W1584733010 @default.
- W2155011421 cites W1957213149 @default.
- W2155011421 cites W1969998054 @default.
- W2155011421 cites W1981315157 @default.
- W2155011421 cites W1982537658 @default.
- W2155011421 cites W1982769349 @default.
- W2155011421 cites W1991133053 @default.
- W2155011421 cites W1995045410 @default.
- W2155011421 cites W1995332691 @default.
- W2155011421 cites W2006519535 @default.
- W2155011421 cites W2012325453 @default.
- W2155011421 cites W2015776459 @default.
- W2155011421 cites W2016475905 @default.
- W2155011421 cites W2016861362 @default.
- W2155011421 cites W2027209056 @default.
- W2155011421 cites W2035404191 @default.
- W2155011421 cites W2040026254 @default.
- W2155011421 cites W2041704171 @default.
- W2155011421 cites W2045971903 @default.
- W2155011421 cites W2050340711 @default.
- W2155011421 cites W2062494337 @default.
- W2155011421 cites W2062561488 @default.
- W2155011421 cites W2066745695 @default.
- W2155011421 cites W2069813795 @default.
- W2155011421 cites W2075847325 @default.
- W2155011421 cites W2083164537 @default.
- W2155011421 cites W2083889661 @default.
- W2155011421 cites W2093551242 @default.
- W2155011421 cites W2097267947 @default.
- W2155011421 cites W2101926858 @default.
- W2155011421 cites W2102437990 @default.
- W2155011421 cites W2106905080 @default.
- W2155011421 cites W2108701295 @default.
- W2155011421 cites W2124270882 @default.
- W2155011421 cites W2127954824 @default.
- W2155011421 cites W2128069859 @default.
- W2155011421 cites W2128223406 @default.
- W2155011421 cites W2129442719 @default.
- W2155011421 cites W2134206256 @default.
- W2155011421 cites W2138639890 @default.
- W2155011421 cites W2143498880 @default.
- W2155011421 cites W2143666216 @default.
- W2155011421 cites W2145289892 @default.
- W2155011421 cites W2156643487 @default.
- W2155011421 cites W2163570329 @default.
- W2155011421 cites W57241277 @default.
- W2155011421 doi "https://doi.org/10.1084/jem.20041356" @default.
- W2155011421 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2211914" @default.
- W2155011421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15545354" @default.
- W2155011421 hasPublicationYear "2004" @default.
- W2155011421 type Work @default.
- W2155011421 sameAs 2155011421 @default.
- W2155011421 citedByCount "223" @default.
- W2155011421 countsByYear W21550114212012 @default.
- W2155011421 countsByYear W21550114212013 @default.
- W2155011421 countsByYear W21550114212014 @default.
- W2155011421 countsByYear W21550114212015 @default.
- W2155011421 countsByYear W21550114212016 @default.
- W2155011421 countsByYear W21550114212017 @default.
- W2155011421 countsByYear W21550114212018 @default.
- W2155011421 countsByYear W21550114212019 @default.
- W2155011421 countsByYear W21550114212020 @default.
- W2155011421 countsByYear W21550114212021 @default.
- W2155011421 countsByYear W21550114212022 @default.
- W2155011421 countsByYear W21550114212023 @default.
- W2155011421 crossrefType "journal-article" @default.
- W2155011421 hasAuthorship W2155011421A5009217310 @default.
- W2155011421 hasAuthorship W2155011421A5013057077 @default.
- W2155011421 hasAuthorship W2155011421A5019884656 @default.
- W2155011421 hasAuthorship W2155011421A5028948869 @default.
- W2155011421 hasAuthorship W2155011421A5040469370 @default.
- W2155011421 hasAuthorship W2155011421A5054910534 @default.
- W2155011421 hasAuthorship W2155011421A5062312342 @default.
- W2155011421 hasBestOaLocation W21550114211 @default.
- W2155011421 hasConcept C159047783 @default.
- W2155011421 hasConcept C173396325 @default.
- W2155011421 hasConcept C19317047 @default.
- W2155011421 hasConcept C193976658 @default.
- W2155011421 hasConcept C203014093 @default.
- W2155011421 hasConcept C2776090121 @default.
- W2155011421 hasConcept C2778170410 @default.