FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155011915> ?p ?o ?g. }

• W2155011915 endingPage "5359" @default.
• W2155011915 startingPage "5348" @default.
• W2155011915 abstract "Ionotropic GABA receptors generally require the products of three subunit genes. By contrast, the GABA receptor needed for locomotion in Caenorhabditis elegans requires only the unc-49 gene. We cloned unc-49 and demonstrated that it possesses an unusual overlapping gene structure. unc-49 contains a single copy of a GABA receptor N terminus, followed by three tandem copies of a GABA receptor C terminus. Using a single promoter, unc-49 generates three distinct GABAA receptor-like subunits by splicing the N terminus to each of the three C-terminal repeats. This organization suggests that the three UNC-49 subunits (UNC-49A, UNC-49B, and UNC-49C) are coordinately rescued and therefore might coassemble to form a heteromultimeric GABA receptor. Surprisingly, only UNC-49B and UNC-49C are expressed at high levels, whereas UNC-49A expression is barely detectable. Green fluorescent protein-tagged UNC-49B and UNC-49C subunits are coexpressed in muscle cells and are colocalized to synaptic regions. UNC-49B and UNC-49C also coassemble efficiently in Xenopus oocytes and HEK-293 cells to form a heteromeric GABA receptor. Together these data argue that UNC-49B and UNC-49C coassemble at the C. elegans neuromuscular junction. Thus, C. elegans is able to encode a heteromeric GABA receptor with a single locus." @default.
• W2155011915 created "2016-06-24" @default.
• W2155011915 creator A5012274305 @default.
• W2155011915 creator A5026863162 @default.
• W2155011915 creator A5077286927 @default.
• W2155011915 creator A5077856861 @default.
• W2155011915 date "1999-07-01" @default.
• W2155011915 modified "2023-10-13" @default.
• W2155011915 title "The<i>Caenorhabditis elegans unc-49</i>Locus Encodes Multiple Subunits of a Heteromultimeric GABA Receptor" @default.
• W2155011915 cites W117302021 @default.
• W2155011915 cites W1557205789 @default.
• W2155011915 cites W1562048214 @default.
• W2155011915 cites W1592900550 @default.
• W2155011915 cites W1668093331 @default.
• W2155011915 cites W1908131908 @default.
• W2155011915 cites W1971126847 @default.
• W2155011915 cites W1973706463 @default.
• W2155011915 cites W1978298955 @default.
• W2155011915 cites W1997437840 @default.
• W2155011915 cites W2007277428 @default.
• W2155011915 cites W2014660497 @default.
• W2155011915 cites W2014669590 @default.
• W2155011915 cites W2044866059 @default.
• W2155011915 cites W2065606887 @default.
• W2155011915 cites W2074821443 @default.
• W2155011915 cites W2079066138 @default.
• W2155011915 cites W2079319779 @default.
• W2155011915 cites W2080292024 @default.
• W2155011915 cites W2097015761 @default.
• W2155011915 cites W2106001183 @default.
• W2155011915 cites W2108080306 @default.
• W2155011915 cites W2122163057 @default.
• W2155011915 cites W2135382901 @default.
• W2155011915 cites W2176076159 @default.
• W2155011915 cites W2186779150 @default.
• W2155011915 cites W2212871432 @default.
• W2155011915 cites W2269031225 @default.
• W2155011915 cites W4295682975 @default.
• W2155011915 doi "https://doi.org/10.1523/jneurosci.19-13-05348.1999" @default.
• W2155011915 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6782323" @default.
• W2155011915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10377345" @default.
• W2155011915 hasPublicationYear "1999" @default.
• W2155011915 type Work @default.
• W2155011915 sameAs 2155011915 @default.
• W2155011915 citedByCount "198" @default.
• W2155011915 countsByYear W21550119152012 @default.
• W2155011915 countsByYear W21550119152013 @default.
• W2155011915 countsByYear W21550119152014 @default.
• W2155011915 countsByYear W21550119152015 @default.
• W2155011915 countsByYear W21550119152016 @default.
• W2155011915 countsByYear W21550119152017 @default.
• W2155011915 countsByYear W21550119152018 @default.
• W2155011915 countsByYear W21550119152019 @default.
• W2155011915 countsByYear W21550119152020 @default.
• W2155011915 countsByYear W21550119152021 @default.
• W2155011915 countsByYear W21550119152022 @default.
• W2155011915 countsByYear W21550119152023 @default.
• W2155011915 crossrefType "journal-article" @default.
• W2155011915 hasAuthorship W2155011915A5012274305 @default.
• W2155011915 hasAuthorship W2155011915A5026863162 @default.
• W2155011915 hasAuthorship W2155011915A5077286927 @default.
• W2155011915 hasAuthorship W2155011915A5077856861 @default.
• W2155011915 hasBestOaLocation W21550119151 @default.
• W2155011915 hasConcept C104292427 @default.
• W2155011915 hasConcept C104317684 @default.
• W2155011915 hasConcept C153911025 @default.
• W2155011915 hasConcept C168258287 @default.
• W2155011915 hasConcept C170493617 @default.
• W2155011915 hasConcept C174510640 @default.
• W2155011915 hasConcept C2776674594 @default.
• W2155011915 hasConcept C2778944004 @default.
• W2155011915 hasConcept C2779535977 @default.
• W2155011915 hasConcept C54355233 @default.
• W2155011915 hasConcept C86803240 @default.
• W2155011915 hasConcept C95444343 @default.
• W2155011915 hasConceptScore W2155011915C104292427 @default.
• W2155011915 hasConceptScore W2155011915C104317684 @default.
• W2155011915 hasConceptScore W2155011915C153911025 @default.
• W2155011915 hasConceptScore W2155011915C168258287 @default.
• W2155011915 hasConceptScore W2155011915C170493617 @default.
• W2155011915 hasConceptScore W2155011915C174510640 @default.
• W2155011915 hasConceptScore W2155011915C2776674594 @default.
• W2155011915 hasConceptScore W2155011915C2778944004 @default.
• W2155011915 hasConceptScore W2155011915C2779535977 @default.
• W2155011915 hasConceptScore W2155011915C54355233 @default.
• W2155011915 hasConceptScore W2155011915C86803240 @default.
• W2155011915 hasConceptScore W2155011915C95444343 @default.
• W2155011915 hasIssue "13" @default.
• W2155011915 hasLocation W21550119151 @default.
• W2155011915 hasLocation W21550119152 @default.
• W2155011915 hasLocation W21550119153 @default.
• W2155011915 hasLocation W21550119154 @default.
• W2155011915 hasOpenAccess W2155011915 @default.
• W2155011915 hasPrimaryLocation W21550119151 @default.
• W2155011915 hasRelatedWork W2001325658 @default.
• W2155011915 hasRelatedWork W2033681203 @default.
• W2155011915 hasRelatedWork W2050122750 @default.
• W2155011915 hasRelatedWork W2070325042 @default.

• next