Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155012110> ?p ?o ?g. }
- W2155012110 endingPage "3501" @default.
- W2155012110 startingPage "3491" @default.
- W2155012110 abstract "Bone marrow-derived mesenchymal stem cells (MSCs) are multipotent progenitors that can commit to osteoblast, chondrocyte, adipocyte, and several other lineages. The proper utilization of stem cells for clinical applications requires an integrated understanding of multiple signal inputs that control maintenance of stemness, proliferation, commitment, and differentiation. Various signaling pathways have been implicated in the regulation of MSC differentiation; however, complexities of pathway interactions, as well as seemingly contradictory results in the literature, create an often confusing and disjointed knowledge base. Several recent publications explore the integration of signaling pathways such as BMP, Wnt, Notch, Hedgehog, and Fibroblast Growth Factors in MSC osteoblast differentiation. The transcription factor Cbfa1/Runx2 has been implicated in these pathways as a potential focal point for signaling integration. This review will outline the current understanding of these pathways and indicate where both spatiotemporal effects during differentiation and comparable experimental conditions need to be considered in order to clarify the outcome(s) of differing regulatory levels of these signaling pathways." @default.
- W2155012110 created "2016-06-24" @default.
- W2155012110 creator A5016269004 @default.
- W2155012110 creator A5084894563 @default.
- W2155012110 date "2011-10-22" @default.
- W2155012110 modified "2023-10-14" @default.
- W2155012110 title "Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation" @default.
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- W2155012110 doi "https://doi.org/10.1002/jcb.23287" @default.