Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155018872> ?p ?o ?g. }
- W2155018872 endingPage "5995" @default.
- W2155018872 startingPage "5986" @default.
- W2155018872 abstract "Embryonic stem (ES) cell self-renewal is regulated by transcription factors, including Oct4, Sox2, and Nanog. A number of additional transcriptional regulators of ES cell self-renewal have recently been identified, including the orphan nuclear receptor estrogen-related receptor beta (Esrrb). However, the mode of action of Esrrb in ES cells is unknown. Here, using an Oct4 affinity screen, we identify Esrrb as an Oct4 partner protein. Esrrb can interact with Oct4 independently of DNA. Esrrb is recruited near the Oct-Sox element in the Nanog proximal promoter, where it positively regulates Nanog expression. Esrrb recruitment to the Nanog promoter requires both the presence of Oct4 and a degenerate estrogen-related receptor DNA element. Consistent with its role in Nanog regulation, expression of the Esrrb protein within the Oct4-positive ES cell population is mosaic and correlates with the mosaic expression of the Nanog protein. Together with previous reports that Nanog may regulate Esrrb gene expression, our results suggest that Esrrb and Nanog act as part of a feedback regulatory circuit that modulates the fluctuating self-renewal capacity of ES cell populations." @default.
- W2155018872 created "2016-06-24" @default.
- W2155018872 creator A5009159444 @default.
- W2155018872 creator A5023008698 @default.
- W2155018872 creator A5058971565 @default.
- W2155018872 creator A5060178337 @default.
- W2155018872 creator A5061720198 @default.
- W2155018872 creator A5066928395 @default.
- W2155018872 creator A5082678653 @default.
- W2155018872 creator A5085359324 @default.
- W2155018872 creator A5087071756 @default.
- W2155018872 date "2008-10-01" @default.
- W2155018872 modified "2023-10-11" @default.
- W2155018872 title "Estrogen-Related Receptor Beta Interacts with Oct4 To Positively Regulate <i>Nanog</i> Gene Expression" @default.
- W2155018872 cites W134825780 @default.
- W2155018872 cites W1608762409 @default.
- W2155018872 cites W1966758700 @default.
- W2155018872 cites W1966809971 @default.
- W2155018872 cites W1970473429 @default.
- W2155018872 cites W1974365957 @default.
- W2155018872 cites W1975163937 @default.
- W2155018872 cites W1975200987 @default.
- W2155018872 cites W1981159999 @default.
- W2155018872 cites W1992949513 @default.
- W2155018872 cites W1993243592 @default.
- W2155018872 cites W1999920730 @default.
- W2155018872 cites W2001153572 @default.
- W2155018872 cites W2010312612 @default.
- W2155018872 cites W2010608530 @default.
- W2155018872 cites W2013035180 @default.
- W2155018872 cites W2015396326 @default.
- W2155018872 cites W2023710119 @default.
- W2155018872 cites W2026298200 @default.
- W2155018872 cites W2046375719 @default.
- W2155018872 cites W2062118486 @default.
- W2155018872 cites W2065746091 @default.
- W2155018872 cites W2080536099 @default.
- W2155018872 cites W2102587137 @default.
- W2155018872 cites W2107575419 @default.
- W2155018872 cites W2108451330 @default.
- W2155018872 cites W2110015307 @default.
- W2155018872 cites W2119554992 @default.
- W2155018872 cites W2126851387 @default.
- W2155018872 cites W2127799088 @default.
- W2155018872 cites W2147477246 @default.
- W2155018872 cites W2149608498 @default.
- W2155018872 cites W2150163104 @default.
- W2155018872 cites W2171609896 @default.
- W2155018872 doi "https://doi.org/10.1128/mcb.00301-08" @default.
- W2155018872 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2547019" @default.
- W2155018872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18662995" @default.
- W2155018872 hasPublicationYear "2008" @default.
- W2155018872 type Work @default.
- W2155018872 sameAs 2155018872 @default.
- W2155018872 citedByCount "156" @default.
- W2155018872 countsByYear W21550188722012 @default.
- W2155018872 countsByYear W21550188722013 @default.
- W2155018872 countsByYear W21550188722014 @default.
- W2155018872 countsByYear W21550188722015 @default.
- W2155018872 countsByYear W21550188722016 @default.
- W2155018872 countsByYear W21550188722017 @default.
- W2155018872 countsByYear W21550188722018 @default.
- W2155018872 countsByYear W21550188722019 @default.
- W2155018872 countsByYear W21550188722020 @default.
- W2155018872 countsByYear W21550188722021 @default.
- W2155018872 countsByYear W21550188722022 @default.
- W2155018872 countsByYear W21550188722023 @default.
- W2155018872 crossrefType "journal-article" @default.
- W2155018872 hasAuthorship W2155018872A5009159444 @default.
- W2155018872 hasAuthorship W2155018872A5023008698 @default.
- W2155018872 hasAuthorship W2155018872A5058971565 @default.
- W2155018872 hasAuthorship W2155018872A5060178337 @default.
- W2155018872 hasAuthorship W2155018872A5061720198 @default.
- W2155018872 hasAuthorship W2155018872A5066928395 @default.
- W2155018872 hasAuthorship W2155018872A5082678653 @default.
- W2155018872 hasAuthorship W2155018872A5085359324 @default.
- W2155018872 hasAuthorship W2155018872A5087071756 @default.
- W2155018872 hasBestOaLocation W21550188721 @default.
- W2155018872 hasConcept C104317684 @default.
- W2155018872 hasConcept C107459253 @default.
- W2155018872 hasConcept C121608353 @default.
- W2155018872 hasConcept C145103041 @default.
- W2155018872 hasConcept C153911025 @default.
- W2155018872 hasConcept C165864922 @default.
- W2155018872 hasConcept C207168726 @default.
- W2155018872 hasConcept C207701140 @default.
- W2155018872 hasConcept C2777933648 @default.
- W2155018872 hasConcept C2908926650 @default.
- W2155018872 hasConcept C530470458 @default.
- W2155018872 hasConcept C54355233 @default.
- W2155018872 hasConcept C84606932 @default.
- W2155018872 hasConcept C86339819 @default.
- W2155018872 hasConcept C86803240 @default.
- W2155018872 hasConcept C95444343 @default.
- W2155018872 hasConceptScore W2155018872C104317684 @default.
- W2155018872 hasConceptScore W2155018872C107459253 @default.
- W2155018872 hasConceptScore W2155018872C121608353 @default.
- W2155018872 hasConceptScore W2155018872C145103041 @default.