FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155020498> ?p ?o ?g. }

• W2155020498 endingPage "1845" @default.
• W2155020498 startingPage "1840" @default.
• W2155020498 abstract "We generated the organic anion transporting polypeptide (Oatp) 1b2 knockout (KO) mouse model and assessed its utility to study hepatic uptake using model compounds: cerivastatin, lovastatin acid, pravastatin, simvastatin acid, rifampicin, and rifamycin SV. A selective panel of liver cytochromes P450 (P450s) (Cyp3a11, Cyp3a13, Cyp3a16, Cyp2c29, and Cyp2c39) and transporters [Oatp1b2, Oatp1a1, Oatp1a4, Oatp1a5; organic anion transporter (Oat) 1, Oat2, Oat3; multidrug resistance gene 1 (Mdr1) a, Mdr1b; bile salt export pump, multidrug resistance associated protein (Mrp) 2, Mrp3; breast cancer resistance protein] were measured by reverse transcription-polymerase chain reaction in both KO and wild-type (WT) male mice. Male KO and WT mice received each model compound s.c. at 3 mg/kg. Blood and liver samples were obtained at 0, 0.5, and 2 h postdose and analyzed using liquid chromatography/tandem mass spectrometry. Liver/plasma concentration ratio (<i>K</i>_p,liver) was calculated. Student9s <i>t</i> test was used to compare the mRNA and <i>K</i>_p,liver between the KO and WT mice. A similar mRNA expression was observed between the KO and WT for the selected P450s and transporters except for Oatp1b2, for which the level was negligible in the KO but prominent in the WT mice with <i>P</i> < 0.0001. The in vivo results showed a differential effect of Oatp1b2 on hepatic uptake of the model compounds, indicating that Oatp1b2 plays a more significant role in the hepatobiliary disposition of rifampicin and lovastatin than the other compounds tested. This study suggests the Oatp1b2 mouse as a useful in vivo tool to understand drug targeting and disposition in the liver." @default.
• W2155020498 created "2016-06-24" @default.
• W2155020498 creator A5004172120 @default.
• W2155020498 creator A5026541170 @default.
• W2155020498 creator A5042488078 @default.
• W2155020498 creator A5044084491 @default.
• W2155020498 creator A5045216818 @default.
• W2155020498 creator A5060205131 @default.
• W2155020498 creator A5060315166 @default.
• W2155020498 creator A5075956923 @default.
• W2155020498 date "2008-06-12" @default.
• W2155020498 modified "2023-10-17" @default.
• W2155020498 title "Utility of a Novel Oatp1b2 Knockout Mouse Model for Evaluating the Role of Oatp1b2 in the Hepatic Uptake of Model Compounds" @default.
• W2155020498 cites W1782655818 @default.
• W2155020498 cites W1971580188 @default.
• W2155020498 cites W1971901938 @default.
• W2155020498 cites W1978116407 @default.
• W2155020498 cites W1978890467 @default.
• W2155020498 cites W1990926703 @default.
• W2155020498 cites W1996402420 @default.
• W2155020498 cites W1997065297 @default.
• W2155020498 cites W2010241890 @default.
• W2155020498 cites W2015755153 @default.
• W2155020498 cites W2018126221 @default.
• W2155020498 cites W2021759214 @default.
• W2155020498 cites W2029294514 @default.
• W2155020498 cites W2039986849 @default.
• W2155020498 cites W2042279723 @default.
• W2155020498 cites W2048593300 @default.
• W2155020498 cites W2052892524 @default.
• W2155020498 cites W2074862075 @default.
• W2155020498 cites W2076385318 @default.
• W2155020498 cites W2081750550 @default.
• W2155020498 cites W2098293164 @default.
• W2155020498 cites W2100323547 @default.
• W2155020498 cites W2101747884 @default.
• W2155020498 cites W2106456872 @default.
• W2155020498 cites W2106535916 @default.
• W2155020498 cites W2115562189 @default.
• W2155020498 cites W2118533330 @default.
• W2155020498 cites W2124775757 @default.
• W2155020498 cites W2125270482 @default.
• W2155020498 cites W2129940653 @default.
• W2155020498 cites W2130955858 @default.
• W2155020498 cites W2132107140 @default.
• W2155020498 cites W2138241559 @default.
• W2155020498 cites W2164578725 @default.
• W2155020498 cites W2167145816 @default.
• W2155020498 doi "https://doi.org/10.1124/dmd.108.020594" @default.
• W2155020498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18556442" @default.
• W2155020498 hasPublicationYear "2008" @default.
• W2155020498 type Work @default.
• W2155020498 sameAs 2155020498 @default.
• W2155020498 citedByCount "50" @default.
• W2155020498 countsByYear W21550204982012 @default.
• W2155020498 countsByYear W21550204982013 @default.
• W2155020498 countsByYear W21550204982014 @default.
• W2155020498 countsByYear W21550204982015 @default.
• W2155020498 countsByYear W21550204982016 @default.
• W2155020498 countsByYear W21550204982017 @default.
• W2155020498 countsByYear W21550204982018 @default.
• W2155020498 countsByYear W21550204982020 @default.
• W2155020498 countsByYear W21550204982021 @default.
• W2155020498 countsByYear W21550204982023 @default.
• W2155020498 crossrefType "journal-article" @default.
• W2155020498 hasAuthorship W2155020498A5004172120 @default.
• W2155020498 hasAuthorship W2155020498A5026541170 @default.
• W2155020498 hasAuthorship W2155020498A5042488078 @default.
• W2155020498 hasAuthorship W2155020498A5044084491 @default.
• W2155020498 hasAuthorship W2155020498A5045216818 @default.
• W2155020498 hasAuthorship W2155020498A5060205131 @default.
• W2155020498 hasAuthorship W2155020498A5060315166 @default.
• W2155020498 hasAuthorship W2155020498A5075956923 @default.
• W2155020498 hasConcept C104317684 @default.
• W2155020498 hasConcept C112705442 @default.
• W2155020498 hasConcept C123584848 @default.
• W2155020498 hasConcept C132040763 @default.
• W2155020498 hasConcept C149011108 @default.
• W2155020498 hasConcept C150903083 @default.
• W2155020498 hasConcept C170493617 @default.
• W2155020498 hasConcept C182704531 @default.
• W2155020498 hasConcept C185592680 @default.
• W2155020498 hasConcept C185867374 @default.
• W2155020498 hasConcept C207001950 @default.
• W2155020498 hasConcept C2776329913 @default.
• W2155020498 hasConcept C2776678969 @default.
• W2155020498 hasConcept C2778163477 @default.
• W2155020498 hasConcept C2778417548 @default.
• W2155020498 hasConcept C2780940807 @default.
• W2155020498 hasConcept C36201501 @default.
• W2155020498 hasConcept C44312359 @default.
• W2155020498 hasConcept C55493867 @default.
• W2155020498 hasConcept C63932345 @default.
• W2155020498 hasConcept C86339819 @default.
• W2155020498 hasConcept C86803240 @default.
• W2155020498 hasConcept C98274493 @default.
• W2155020498 hasConceptScore W2155020498C104317684 @default.
• W2155020498 hasConceptScore W2155020498C112705442 @default.

• next