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- W2155030437 abstract "Cyclooxygenase (COX) enzyme is responsible for the formation of important biological mediators including prostaglandins, prostacyclin and thromboxane to trigger many physiological and patho-physiological responses. COXs exist in two distinct isoforms, a constitutively expressed form (COX-1) and an inducible form (COX-2). COX-2 is involved in the body’s response to inflammation and pain. Moreover, it has also been shown that COX-2 is overexpressed in many human cancers, and that COX-2 is involved in various neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease. COX-2 inhibitors are among the most widely used therapeutics for the treatment of chronic and acute pain and inflammation. Non-invasive monitoring of COX-2 functional expression by means of nuclear molecular imaging techniques like positron emission tomography (PET) and single photon emission computed tomography (SPECT) might provide unique opportunities to obtain data on COX-2 expression levels during disease manifestation and progression to study potential roles of COX-2 under various pathological conditions. The present review summarizes recent research efforts directed to the design and synthesis of radiotracers as molecular probes with special emphasis on COX-2 imaging. Keywords: Cyclooxygenase-2, radiotracer, molecular imaging, positron emission tomography, single photon emission computed tomography." @default.
- W2155030437 created "2016-06-24" @default.
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- W2155030437 date "2013-10-31" @default.
- W2155030437 modified "2023-09-26" @default.
- W2155030437 title "Radiotracers for Molecular Imaging of Cyclooxygenase-2 (COX-2) Enzyme" @default.
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- W2155030437 doi "https://doi.org/10.2174/09298673113206660260" @default.
- W2155030437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24059237" @default.
- W2155030437 hasPublicationYear "2013" @default.
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