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- W2155055433 abstract "A prospective, randomized, double-blind study was undertaken to evaluate Zamifenacin 30 mg (Pfizer Ltd), a novel, orally-administered, gut-specific muscarinic receptor antagonist, as an adjuvant to the double contrast barium enema examination (DCBE). Zamifenacin was compared with placebo in terms of side-effects and colonic tone. Analysis of colonic tone was carried out by two independent observers, using a subjective grading system and also by an objective method using computerized planimetry. Interobserver variability was also assessed. Zamifenacin is safe and well tolerated but at the prescribed dose is an ineffective antispasmodic for DCBE. Subjective assessment of colonic tone was shown to be of limited value whilst the objective analysis using computerized planimetry was reliable and highly reproducible." @default.
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- W2155055433 date "1996-04-01" @default.
- W2155055433 modified "2023-10-18" @default.
- W2155055433 title "Computerized planimetry in the objective assessment of the antispasmodic effect of Zamifenacin in double contrast barium enemas" @default.
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- W2155055433 doi "https://doi.org/10.1259/0007-1285-69-820-301" @default.
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