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• W2155058248 abstract "Detoxification capacity of enzymes in the liver is thought to be the primary factor governing dietary toxin intake by mammalian herbivores. Recently, toxin absorption in the gut was proposed as an alternative process that also influences toxin intake. We examined the role of the gut in regulating toxin absorption by quantifying excretion of a plant secondary compound in the feces. We hypothesized that specialists have a greater capacity to reduce intestinal absorption of toxins than do generalists. To test this hypothesis, we compared fecal excretion of alpha‐pinene in specialist (Neotoma stephensi) and generalist (Neotoma albigula) woodrats. Alpha‐pinene is the most abundant monoterpene in Juniperus monosperma, which occurs in the natural diet of both woodrat species. Woodrats were fed alpha‐pinene in diets containing juniper foliage for 3 wk and, in a separate experiment, were given a single oral dose of alpha‐pinene. Feces were collected from animals at the end of each experiment and analyzed for alpha‐pinene concentration using gas chromatography. Both woodrat species excreted unchanged alpha‐pinene in the feces. However, specialist woodrats excreted 40% more alpha‐pinene per unit ingested from a juniper diet and excreted nearly four times a greater percentage of an oral dose of alpha‐pinene compared with generalists." @default.
• W2155058248 created "2016-06-24" @default.
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• W2155058248 date "2004-01-01" @default.
• W2155058248 modified "2023-10-16" @default.
• W2155058248 title "A Specialist Herbivore (<i>Neotoma stephensi</i>) Absorbs Fewer Plant Toxins than Does a Generalist (<i>Neotoma albigula</i>)" @default.
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• W2155058248 doi "https://doi.org/10.1086/378923" @default.
• W2155058248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15057724" @default.
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