FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155058417> ?p ?o ?g. }

• W2155058417 endingPage "922" @default.
• W2155058417 startingPage "913" @default.
• W2155058417 abstract "Inotropic interventions were compared with respect to their maximum effect on force of contraction in rat myocardium to identify limiting steps in calcium handling. Peak force, sarcomere length, and action potentials were measured in thin ventricular trabeculae. Relevant control conditions were stimulation frequency, 0.2 Hz; [Ca2+]o, 1 mM; [K+]o, 5 mM; [Na+]o, 150 mM. The inotropic interventions and results were as follows. 1) The interventions of high [Ca2+]o, low [Na+]o, high [K+]o, addition of tetraethylammonium chloride, or postextrasystolic potentiation resulted in approximately the same (within 5%) maximum force (Fmax). Above the respective optimum doses, force declined and aftercontractions were often observed. Combinations of the different interventions never enhanced force to above Fmax. This suggests that Fmax is determined by a maximum level of Ca2+ in the sarcoplasmic reticulum, above which spontaneous release occurs. 2) Sr2+ (10 mM) caused an increase of force to 1.3 X Fmax and lengthening of contraction and action potentials. The force-sarcomere length relation was, then, similar to that in skinned fibers at maximum activation. Hence, 1.3 X Fmax reflects saturation of the sarcomeres. We postulate that a large influx of Sr2+ during the long action potential can circumvent the reticulum and activate the sarcomeres directly. When the reticulum was blocked with ryanodine, maximum force of tetanic contractions was about 1.1 X Fmax. This result supports the above conclusions. 3) Isoproterenol increased force to a maximum that was 20% below Fmax and shortened the contraction. This may be due to a decreased sensitivity of the sarcomeres to Ca2+ or to stimulation of the Ca2+ pump in the reticulum, that is, an increasing fraction of the released Ca2+ is sequestered before it can activate the sarcomeres. Thus, three factors that limit force production were identified, depending on the inotropic stimulus." @default.
• W2155058417 created "2016-06-24" @default.
• W2155058417 creator A5028288950 @default.
• W2155058417 creator A5056694490 @default.
• W2155058417 creator A5073908511 @default.
• W2155058417 creator A5087790272 @default.
• W2155058417 date "1990-10-01" @default.
• W2155058417 modified "2023-09-23" @default.
• W2155058417 title "Sarcolemma, sarcoplasmic reticulum, and sarcomeres as limiting factors in force production in rat heart." @default.
• W2155058417 cites W1582847673 @default.
• W2155058417 cites W1752051260 @default.
• W2155058417 cites W1970206897 @default.
• W2155058417 cites W1978789401 @default.
• W2155058417 cites W1985236300 @default.
• W2155058417 cites W1986983479 @default.
• W2155058417 cites W1989084375 @default.
• W2155058417 cites W1996140321 @default.
• W2155058417 cites W1996288114 @default.
• W2155058417 cites W1997868375 @default.
• W2155058417 cites W1999077415 @default.
• W2155058417 cites W2003290962 @default.
• W2155058417 cites W2007460875 @default.
• W2155058417 cites W2011128997 @default.
• W2155058417 cites W2023318071 @default.
• W2155058417 cites W2025975686 @default.
• W2155058417 cites W2026597551 @default.
• W2155058417 cites W2030044284 @default.
• W2155058417 cites W2038964166 @default.
• W2155058417 cites W2042148321 @default.
• W2155058417 cites W2049181319 @default.
• W2155058417 cites W2054047552 @default.
• W2155058417 cites W2057062767 @default.
• W2155058417 cites W2076945382 @default.
• W2155058417 cites W2079334571 @default.
• W2155058417 cites W2089132408 @default.
• W2155058417 cites W2099444831 @default.
• W2155058417 cites W2110608925 @default.
• W2155058417 cites W2112784419 @default.
• W2155058417 cites W2118147972 @default.
• W2155058417 cites W2126000956 @default.
• W2155058417 cites W2126198444 @default.
• W2155058417 cites W2144161944 @default.
• W2155058417 cites W2146261511 @default.
• W2155058417 cites W2158423996 @default.
• W2155058417 cites W2327475911 @default.
• W2155058417 cites W2401086562 @default.
• W2155058417 cites W28661400 @default.
• W2155058417 cites W2885090528 @default.
• W2155058417 doi "https://doi.org/10.1161/01.res.67.4.913" @default.
• W2155058417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2208614" @default.
• W2155058417 hasPublicationYear "1990" @default.
• W2155058417 type Work @default.
• W2155058417 sameAs 2155058417 @default.
• W2155058417 citedByCount "18" @default.
• W2155058417 countsByYear W21550584172014 @default.
• W2155058417 countsByYear W21550584172017 @default.
• W2155058417 countsByYear W21550584172018 @default.
• W2155058417 countsByYear W21550584172019 @default.
• W2155058417 countsByYear W21550584172020 @default.
• W2155058417 crossrefType "journal-article" @default.
• W2155058417 hasAuthorship W2155058417A5028288950 @default.
• W2155058417 hasAuthorship W2155058417A5056694490 @default.
• W2155058417 hasAuthorship W2155058417A5073908511 @default.
• W2155058417 hasAuthorship W2155058417A5087790272 @default.
• W2155058417 hasBestOaLocation W21550584171 @default.
• W2155058417 hasConcept C105702510 @default.
• W2155058417 hasConcept C113217602 @default.
• W2155058417 hasConcept C12554922 @default.
• W2155058417 hasConcept C126322002 @default.
• W2155058417 hasConcept C155710745 @default.
• W2155058417 hasConcept C158617107 @default.
• W2155058417 hasConcept C163415756 @default.
• W2155058417 hasConcept C178790620 @default.
• W2155058417 hasConcept C185592680 @default.
• W2155058417 hasConcept C199096232 @default.
• W2155058417 hasConcept C207200792 @default.
• W2155058417 hasConcept C2776050358 @default.
• W2155058417 hasConcept C2779732806 @default.
• W2155058417 hasConcept C2779959927 @default.
• W2155058417 hasConcept C519063684 @default.
• W2155058417 hasConcept C55493867 @default.
• W2155058417 hasConcept C68731436 @default.
• W2155058417 hasConcept C71924100 @default.
• W2155058417 hasConcept C86803240 @default.
• W2155058417 hasConceptScore W2155058417C105702510 @default.
• W2155058417 hasConceptScore W2155058417C113217602 @default.
• W2155058417 hasConceptScore W2155058417C12554922 @default.
• W2155058417 hasConceptScore W2155058417C126322002 @default.
• W2155058417 hasConceptScore W2155058417C155710745 @default.
• W2155058417 hasConceptScore W2155058417C158617107 @default.
• W2155058417 hasConceptScore W2155058417C163415756 @default.
• W2155058417 hasConceptScore W2155058417C178790620 @default.
• W2155058417 hasConceptScore W2155058417C185592680 @default.
• W2155058417 hasConceptScore W2155058417C199096232 @default.
• W2155058417 hasConceptScore W2155058417C207200792 @default.
• W2155058417 hasConceptScore W2155058417C2776050358 @default.
• W2155058417 hasConceptScore W2155058417C2779732806 @default.
• W2155058417 hasConceptScore W2155058417C2779959927 @default.

• next