FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155069081> ?p ?o ?g. }

• W2155069081 endingPage "8196" @default.
• W2155069081 startingPage "8189" @default.
• W2155069081 abstract "The closely linked H19 and Igf2 genes show highly similar patterns of gene expression but are reciprocally imprinted. H19 is expressed almost exclusively from the maternally inherited chromosome, while Igf2 expression is mostly from the paternal chromosome. In humans, loss of imprinting at this locus is associated with tumors and with developmental disorders. Monoallelic expression at the imprinted Igf2/H19 locus occurs by at least two distinct mechanisms: a developmentally regulated silencing of the paternal H19 promoter, and transcriptional insulation of the maternal Igf2 promoters. Both mechanisms of allele-specific silencing are ultimately dependent on a common cis-acting element located just upstream of the H19 promoter. The coordinated expression patterns and some experimental data support the idea that positive regulatory elements are also shared by the two genes. To clarify the organization and function of positive and negative regulatory elements at the H19/Igf2 locus, we analyzed two mouse mutations. First, we generated a deletion allele to localize enhancers used in vivo for expression of both H19 and Igf2 in mesodermal tissues to sequences downstream of the H19 gene. Coincidentally, we demonstrated that some expression of Igf2 is independent of the shared enhancer element. Second, we used this new information to further characterize an ectopic H19 differentially regulated region and the associated insulator. We demonstrated that its activity is parent-of-origin dependent. In contrast to recent results from Drosophila model systems; we showed that this duplication of a mammalian insulator does not interfere with its normal function. Implications of these findings for current models for monoallelic gene expression at this locus are discussed." @default.
• W2155069081 created "2016-06-24" @default.
• W2155069081 creator A5011253096 @default.
• W2155069081 creator A5067526078 @default.
• W2155069081 creator A5078893201 @default.
• W2155069081 date "2001-12-01" @default.
• W2155069081 modified "2023-10-13" @default.
• W2155069081 title "Regulatory Mechanisms at the Mouse<i>Igf2/H19</i> Locus" @default.
• W2155069081 cites W100503789 @default.
• W2155069081 cites W1572003867 @default.
• W2155069081 cites W1642850099 @default.
• W2155069081 cites W1643500256 @default.
• W2155069081 cites W1646817159 @default.
• W2155069081 cites W1669374546 @default.
• W2155069081 cites W1896524516 @default.
• W2155069081 cites W1922454803 @default.
• W2155069081 cites W1927984809 @default.
• W2155069081 cites W1971235075 @default.
• W2155069081 cites W1971910773 @default.
• W2155069081 cites W1972995961 @default.
• W2155069081 cites W1974883337 @default.
• W2155069081 cites W1975812358 @default.
• W2155069081 cites W1981639631 @default.
• W2155069081 cites W1982574784 @default.
• W2155069081 cites W1991611644 @default.
• W2155069081 cites W1998210025 @default.
• W2155069081 cites W2002409372 @default.
• W2155069081 cites W2002877822 @default.
• W2155069081 cites W2011247275 @default.
• W2155069081 cites W2016076410 @default.
• W2155069081 cites W2016833937 @default.
• W2155069081 cites W201842558 @default.
• W2155069081 cites W2032119463 @default.
• W2155069081 cites W2042846772 @default.
• W2155069081 cites W2051784499 @default.
• W2155069081 cites W2058172887 @default.
• W2155069081 cites W2058471882 @default.
• W2155069081 cites W2058834628 @default.
• W2155069081 cites W2072495661 @default.
• W2155069081 cites W2074906225 @default.
• W2155069081 cites W2082968298 @default.
• W2155069081 cites W2093664707 @default.
• W2155069081 cites W2104655620 @default.
• W2155069081 cites W2104992956 @default.
• W2155069081 cites W2113886026 @default.
• W2155069081 cites W2114768769 @default.
• W2155069081 cites W2115430605 @default.
• W2155069081 cites W2118962630 @default.
• W2155069081 cites W2126414759 @default.
• W2155069081 cites W2130639565 @default.
• W2155069081 cites W2153665057 @default.
• W2155069081 cites W2159250091 @default.
• W2155069081 cites W2163930090 @default.
• W2155069081 cites W2164331758 @default.
• W2155069081 cites W2164704209 @default.
• W2155069081 cites W2168819459 @default.
• W2155069081 cites W2185773995 @default.
• W2155069081 cites W4213185988 @default.
• W2155069081 doi "https://doi.org/10.1128/mcb.21.23.8189-8196.2001" @default.
• W2155069081 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/99983" @default.
• W2155069081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11689707" @default.
• W2155069081 hasPublicationYear "2001" @default.
• W2155069081 type Work @default.
• W2155069081 sameAs 2155069081 @default.
• W2155069081 citedByCount "105" @default.
• W2155069081 countsByYear W21550690812012 @default.
• W2155069081 countsByYear W21550690812013 @default.
• W2155069081 countsByYear W21550690812014 @default.
• W2155069081 countsByYear W21550690812015 @default.
• W2155069081 countsByYear W21550690812016 @default.
• W2155069081 countsByYear W21550690812017 @default.
• W2155069081 countsByYear W21550690812018 @default.
• W2155069081 countsByYear W21550690812019 @default.
• W2155069081 countsByYear W21550690812020 @default.
• W2155069081 countsByYear W21550690812021 @default.
• W2155069081 countsByYear W21550690812022 @default.
• W2155069081 countsByYear W21550690812023 @default.
• W2155069081 crossrefType "journal-article" @default.
• W2155069081 hasAuthorship W2155069081A5011253096 @default.
• W2155069081 hasAuthorship W2155069081A5067526078 @default.
• W2155069081 hasAuthorship W2155069081A5078893201 @default.
• W2155069081 hasBestOaLocation W21550690811 @default.
• W2155069081 hasConcept C101762097 @default.
• W2155069081 hasConcept C104317684 @default.
• W2155069081 hasConcept C111936080 @default.
• W2155069081 hasConcept C119056186 @default.
• W2155069081 hasConcept C119599485 @default.
• W2155069081 hasConcept C127413603 @default.
• W2155069081 hasConcept C150194340 @default.
• W2155069081 hasConcept C165864922 @default.
• W2155069081 hasConcept C180754005 @default.
• W2155069081 hasConcept C190727270 @default.
• W2155069081 hasConcept C201492766 @default.
• W2155069081 hasConcept C212702 @default.
• W2155069081 hasConcept C54355233 @default.
• W2155069081 hasConcept C84597430 @default.
• W2155069081 hasConcept C86803240 @default.
• W2155069081 hasConcept C94715292 @default.

• next