FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155087156> ?p ?o ?g. }

• W2155087156 endingPage "E1347" @default.
• W2155087156 startingPage "E1339" @default.
• W2155087156 abstract "Hearts utilize fatty acids as a primary source of energy. The sources of those lipids include free fatty acids and lipoprotein triglycerides. Deletion of the primary triglyceride-hydrolyzing enzyme lipoprotein lipase (LPL) leads to cardiac dysfunction. Whether heart LPL-knockout (hLPL0) mice are compromised due a deficiency in energetic substrates is unknown. To test whether alternative sources of energy will prevent cardiac dysfunction in hLPL0 mice, two different models were used to supply nonlipid energy. 1) hLPL0 mice were crossed with mice transgenically expressing GLUT1 in cardiomyocytes to increase glucose uptake into the heart; this cross-corrected cardiac dysfunction, reduced cardiac hypertrophy, and increased myocardial ATP. 2) Mice were randomly assigned to a sedentary or training group (swimming) at 3 mo of age, which leads to increased skeletal muscle production of lactate. hLPL0 mice had greater expression of the lactate transporter monocarboxylate transporter-1 (MCT-1) and increased cardiac lactate uptake. Compared with hearts from sedentary hLPL0 mice, hearts from trained hLPL0 mice had adaptive hypertrophy and improved cardiac function. We conclude that defective energy intake and not the reduced uptake of fat-soluble vitamins or cholesterol is responsible for cardiac dysfunction in hLPL0 mice. In addition, our studies suggest that adaptations in cardiac metabolism contribute to the beneficial effects of exercise on the myocardium of patients with heart failure." @default.
• W2155087156 created "2016-06-24" @default.
• W2155087156 creator A5009194752 @default.
• W2155087156 creator A5009957103 @default.
• W2155087156 creator A5011475864 @default.
• W2155087156 creator A5015545004 @default.
• W2155087156 creator A5026568823 @default.
• W2155087156 creator A5027749935 @default.
• W2155087156 creator A5029700686 @default.
• W2155087156 creator A5037782398 @default.
• W2155087156 creator A5052678510 @default.
• W2155087156 creator A5062451710 @default.
• W2155087156 creator A5066507748 @default.
• W2155087156 creator A5071971658 @default.
• W2155087156 creator A5087806461 @default.
• W2155087156 date "2013-12-01" @default.
• W2155087156 modified "2023-10-13" @default.
• W2155087156 title "Rescue of heart lipoprotein lipase-knockout mice confirms a role for triglyceride in optimal heart metabolism and function" @default.
• W2155087156 cites W1249459315 @default.
• W2155087156 cites W1570914098 @default.
• W2155087156 cites W1925469453 @default.
• W2155087156 cites W1967600689 @default.
• W2155087156 cites W1971932655 @default.
• W2155087156 cites W1981956598 @default.
• W2155087156 cites W1982055384 @default.
• W2155087156 cites W1986737365 @default.
• W2155087156 cites W1988027435 @default.
• W2155087156 cites W1988064154 @default.
• W2155087156 cites W2000195715 @default.
• W2155087156 cites W2001210998 @default.
• W2155087156 cites W2013061950 @default.
• W2155087156 cites W2015707221 @default.
• W2155087156 cites W2023731159 @default.
• W2155087156 cites W2029789532 @default.
• W2155087156 cites W2030016656 @default.
• W2155087156 cites W2030711653 @default.
• W2155087156 cites W2034679367 @default.
• W2155087156 cites W2046579148 @default.
• W2155087156 cites W2057300859 @default.
• W2155087156 cites W2059491453 @default.
• W2155087156 cites W2061974967 @default.
• W2155087156 cites W2064018881 @default.
• W2155087156 cites W2064056229 @default.
• W2155087156 cites W2068967007 @default.
• W2155087156 cites W2074652316 @default.
• W2155087156 cites W2076560278 @default.
• W2155087156 cites W2082549199 @default.
• W2155087156 cites W2095280972 @default.
• W2155087156 cites W2096380667 @default.
• W2155087156 cites W2099343002 @default.
• W2155087156 cites W2106554004 @default.
• W2155087156 cites W2109762329 @default.
• W2155087156 cites W2116798343 @default.
• W2155087156 cites W2119792920 @default.
• W2155087156 cites W2126734216 @default.
• W2155087156 cites W2127661519 @default.
• W2155087156 cites W2128606426 @default.
• W2155087156 cites W2132924005 @default.
• W2155087156 cites W2133450507 @default.
• W2155087156 cites W2135916759 @default.
• W2155087156 cites W2136756954 @default.
• W2155087156 cites W2137273480 @default.
• W2155087156 cites W2138540535 @default.
• W2155087156 cites W2139691561 @default.
• W2155087156 cites W2140231697 @default.
• W2155087156 cites W2142786100 @default.
• W2155087156 cites W2144422566 @default.
• W2155087156 cites W2151607481 @default.
• W2155087156 cites W2164649219 @default.
• W2155087156 cites W2168526937 @default.
• W2155087156 cites W2171185920 @default.
• W2155087156 cites W4234122477 @default.
• W2155087156 doi "https://doi.org/10.1152/ajpendo.00349.2013" @default.
• W2155087156 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3882371" @default.
• W2155087156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24085031" @default.
• W2155087156 hasPublicationYear "2013" @default.
• W2155087156 type Work @default.
• W2155087156 sameAs 2155087156 @default.
• W2155087156 citedByCount "15" @default.
• W2155087156 countsByYear W21550871562015 @default.
• W2155087156 countsByYear W21550871562016 @default.
• W2155087156 countsByYear W21550871562017 @default.
• W2155087156 countsByYear W21550871562018 @default.
• W2155087156 countsByYear W21550871562019 @default.
• W2155087156 countsByYear W21550871562020 @default.
• W2155087156 countsByYear W21550871562022 @default.
• W2155087156 countsByYear W21550871562023 @default.
• W2155087156 crossrefType "journal-article" @default.
• W2155087156 hasAuthorship W2155087156A5009194752 @default.
• W2155087156 hasAuthorship W2155087156A5009957103 @default.
• W2155087156 hasAuthorship W2155087156A5011475864 @default.
• W2155087156 hasAuthorship W2155087156A5015545004 @default.
• W2155087156 hasAuthorship W2155087156A5026568823 @default.
• W2155087156 hasAuthorship W2155087156A5027749935 @default.
• W2155087156 hasAuthorship W2155087156A5029700686 @default.
• W2155087156 hasAuthorship W2155087156A5037782398 @default.
• W2155087156 hasAuthorship W2155087156A5052678510 @default.
• W2155087156 hasAuthorship W2155087156A5062451710 @default.

• next