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• W2155087261 abstract "Summary Background and objectives Previous studies reporting an association between high BP and high sodium and low potassium intake or urinary sodium/potassium ratio (U[Na + ]/[K + ]) primarily included white men and did not control for cardiovascular risk factors. Design, setting, participants, & measurements This cross-sectional study investigated the association of U[Na + ]/[K + ] with BP in 3303 participants using robust linear regression. Results Mean age was 43±10 years, 56% of participants were women, and 52% were African American. BP was higher in African Americans than in non–African Americans, 131/81±20/11 versus 120/76±16/9 mmHg ( P <0.001). Mean U[Na + ]/[K + ] was 4.4±3.0 in African Americans and 4.1±2.5 in non–African Americans ( P =0.002), with medians (interquartile ranges) of 3.7 (3.2) and 3.6 (2.8). Systolic BP increased by 1.6 mmHg (95% confidence interval, 1.0, 2.2) and diastolic BP by 1.0 mmHg (95% confidence interval, 0.6, 1.4) for each 3-unit increase in U[Na + ]/[K + ] ( P <0.001 for both). This association remained significant after adjusting for diabetes mellitus, smoking, body mass index, total cholesterol, GFR, and urine albumin/creatinine ratio. There was no interaction between African-American race and U[Na + ]/[K + ], but for any given value of U[Na + ]/[K + ], both systolic BP and diastolic BP were higher in African Americans than in non–African Americans. The diastolic BP increase was higher in men than in women per 3-unit increase in U[Na + ]/[K + ] (1.6 versus 0.9 mmHg, interaction P =0.03). Conclusions Dietary Na + excess and K + deficiency may play an important role in the pathogenesis of hypertension independent of cardiovascular risk factors. This association may be more pronounced in men than in women." @default.
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• W2155087261 date "2012-02-01" @default.
• W2155087261 modified "2023-10-17" @default.
• W2155087261 title "Association of Urinary Sodium/Potassium Ratio with Blood Pressure" @default.
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• W2155087261 doi "https://doi.org/10.2215/cjn.02060311" @default.
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