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- W2155095982 abstract "The expression of beta interferon genes from humans and mice is under the immediate control of a virus-responsive element (VRE) that terminates 110 bp upstream from the transcriptional start site. Whereas a wealth of information is available for the enhanceosome that is formed on the VRE upon the signals generated by viral infection, early observations indicating the existence of other far-upstream control elements have so far remained without a molecular fundament. Guided by a computational analysis of DNA structures, we could locate three as-yet-unknown transcription factor-binding regions at -0.5, -2, and -3 kb. Our present study delineates the interplay of factors YY1 and YY2 as it occurs at the sites at -3 kb and -2 kb (otherwise called HS1 and HS2), consistent with the idea that the novel factor YY2 antagonizes the negative actions exerted by YY1. Differences between the human and murine control regions will be described." @default.
- W2155095982 created "2016-06-24" @default.
- W2155095982 creator A5021528284 @default.
- W2155095982 creator A5051370899 @default.
- W2155095982 date "2005-11-01" @default.
- W2155095982 modified "2023-09-27" @default.
- W2155095982 title "Enhanceosome Formation over the Beta Interferon Promoter Underlies a Remote-Control Mechanism Mediated by YY1 and YY2" @default.
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- W2155095982 doi "https://doi.org/10.1128/mcb.25.22.10159-10170.2005" @default.
- W2155095982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1280260" @default.
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