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• W2155107321 abstract "Preliminary studies, based on a region-of-interest approach, suggest that quantitative magnetization transfer (qMT), an extension of magnetization transfer imaging, provides complementary information to conventional magnetic resonance imaging (MRI) in the characterisation of Alzheimer's disease (AD). The aim of this study was to extend these findings to the whole brain, using a voxel-wise approach. We recruited 19 AD patients and 11 healthy subjects (HS). All subjects had an MRI acquisition at 3.0 T including a T1-weighted volume, 12 MT-weighted volumes for qMT, and data for computing T1 and B1 maps. The T1-weighted volumes were processed to yield grey matter (GM) volumetric maps, while the other sequences were used to compute qMT parametric maps of the whole brain. qMT maps were warped to standard space and smoothed, and subsequently compared between groups. Of all the qMT parameters considered, only the forward exchange rate, RM0B, showed significant group differences. These images were therefore retained for the multimodal statistical analysis, designed to locate brain regions of RM0B differences between AD and HS groups, adjusting for local GM atrophy. Widespread areas of reduced RM0B were found in AD patients, mainly located in the hippocampus, in the temporal lobe, in the posterior cingulate and in the parietal cortex. These results indicate that, among qMT parameters, RM0B is the most sensitive to AD pathology. This quantity is altered in the hippocampus of patients with AD (as found by previous works) but also in other brain areas, that PET studies have highlighted as involved with both, reduced glucose metabolism and amyloid β deposition. RM0B might reflect, through the measurement of the efficiency of MT exchange, some information with a specific pathological counterpart. Given previous evidence of a strict relationship between RM0B and intracellular pH, an intriguing speculation is that our findings might reflect metabolic changes related to mitochondrial dysfunction, which has been proposed as a contributor to neurodegeneration in AD." @default.
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• W2155107321 date "2012-01-01" @default.
• W2155107321 modified "2023-10-10" @default.
• W2155107321 title "Quantitative magnetization transfer provides information complementary to grey matter atrophy in Alzheimer's disease brains" @default.
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• W2155107321 cites W1847168837 @default.
• W2155107321 cites W1967295801 @default.
• W2155107321 cites W1968006940 @default.
• W2155107321 cites W1982438030 @default.
• W2155107321 cites W1982974584 @default.
• W2155107321 cites W1984317687 @default.
• W2155107321 cites W1985747467 @default.
• W2155107321 cites W1988568308 @default.
• W2155107321 cites W1990499131 @default.
• W2155107321 cites W1992219232 @default.
• W2155107321 cites W1992400310 @default.
• W2155107321 cites W1995719450 @default.
• W2155107321 cites W1997417397 @default.
• W2155107321 cites W1999502628 @default.
• W2155107321 cites W1999977619 @default.
• W2155107321 cites W2001738630 @default.
• W2155107321 cites W2002413948 @default.
• W2155107321 cites W2005503435 @default.
• W2155107321 cites W2007276643 @default.
• W2155107321 cites W2007572953 @default.
• W2155107321 cites W2010484888 @default.
• W2155107321 cites W2020008880 @default.
• W2155107321 cites W2027711842 @default.
• W2155107321 cites W2036142047 @default.
• W2155107321 cites W2044288513 @default.
• W2155107321 cites W2047410002 @default.
• W2155107321 cites W2049512075 @default.
• W2155107321 cites W2050214509 @default.
• W2155107321 cites W2051568462 @default.
• W2155107321 cites W2053887731 @default.
• W2155107321 cites W2066520774 @default.
• W2155107321 cites W2067151224 @default.
• W2155107321 cites W2070181269 @default.
• W2155107321 cites W2070302549 @default.
• W2155107321 cites W2070753161 @default.
• W2155107321 cites W2080340510 @default.
• W2155107321 cites W2080732726 @default.
• W2155107321 cites W2088159177 @default.
• W2155107321 cites W2089182319 @default.
• W2155107321 cites W2094325308 @default.
• W2155107321 cites W2102239739 @default.
• W2155107321 cites W2104612326 @default.
• W2155107321 cites W2105236625 @default.
• W2155107321 cites W2107915383 @default.
• W2155107321 cites W2115614582 @default.
• W2155107321 cites W2131437398 @default.
• W2155107321 cites W2133903921 @default.
• W2155107321 cites W2135431511 @default.
• W2155107321 cites W2138305487 @default.
• W2155107321 cites W2138878035 @default.
• W2155107321 cites W2140257080 @default.
• W2155107321 cites W2142240143 @default.
• W2155107321 cites W2147777230 @default.
• W2155107321 cites W2148726987 @default.
• W2155107321 cites W2152545005 @default.
• W2155107321 cites W2152559989 @default.
• W2155107321 cites W2156220037 @default.
• W2155107321 cites W2159838014 @default.
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• W2155107321 cites W2604116219 @default.
• W2155107321 cites W2985100448 @default.
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• W2155107321 doi "https://doi.org/10.1016/j.neuroimage.2011.09.043" @default.
• W2155107321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21983184" @default.
• W2155107321 hasPublicationYear "2012" @default.
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