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- W2155108361 abstract "The integration of various fields of investigation is of key importance to fully comprehending endocrine function. Here, I enact the theoretical framework of Nikolaas Tinbergen’s four questions for understanding behavior to help bridge the wide gap that exists between our relatively reductionist molecular knowledge of a particular neurohormone, gonadotropin-inhibitory hormone (GnIH), and its place in animal behavior. Hypothalamic GnIH, upon its discovery in 2000, was so named because of its inhibitory effect on the release of the gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH), from the pituitary. Because gonadotropins are necessary for reproduction, this finding stimulated questions about the functional significance of GnIH in reproduction and sexual behavior. After over a decade of research, invaluable knowledge has been gained regarding the mechanistic attributes of GnIH (mammalian homolog, RFamide-related peptide (RFRP)) in a variety of vertebrate species. However, many questions remain regarding the effect of the environment on GnIH and the subsequent effects of GnIH on behavior. I review the role of GnIH in shaping behavior using the framework of Tinbergen’s four questions of mechanism, ontogeny, function and phylogeny. The studies I review were conducted in various species of mammals, birds, and in one species of fish. Because GnIH can play a role in mediating behaviors such as those important for reproduction, sociality, feeding, and the stress response in a variety of species, an integrative approach to the study of GnIH will help provide a multipronged schema for answering questions of GnIH function. By using the framework highlighted by Tinbergen’s four questions, we will deepen and enhance our knowledge of the role of hormones in behavior from the point of view of the mechanisms involved." @default.
- W2155108361 created "2016-06-24" @default.
- W2155108361 creator A5070779225 @default.
- W2155108361 date "2014-07-01" @default.
- W2155108361 modified "2023-10-14" @default.
- W2155108361 title "An integrative overview of the role of gonadotropin-inhibitory hormone in behavior: Applying Tinbergen’s four questions" @default.
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