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• W2155111319 abstract "HomeHypertensionVol. 35, No. 6On the Biological Actions of Intracellular Angiotensin Free AccessOtherPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessOtherPDF/EPUBOn the Biological Actions of Intracellular Angiotensin Richard N. Re Richard N. ReRichard N. Re From the Alton Oschner Medical Foundation, New Orleans, La. Search for more papers by this author Originally published1 Jun 2000https://doi.org/10.1161/01.HYP.35.6.1189Hypertension. 2000;35:1189–1190Other version(s) of this articleYou are viewing the most recent version of this article. Previous versions: September 8, 2018: Previous Version of Record Over the last 2 decades, it has become clear that angiotensin can be generated not only in the systemic circulation but also in multiple tissue sites, where its production can be regulated by local factors. Given the ability of angiotensin II to influence target cell proliferation, hypertrophy, and apoptosis, tissue angiotensin systems potentially play an important role in a wide variety of physiological processes. In this issue of Hypertension, De Mello and Danser1 review the evidence for the synthesis of angiotensin II in the heart and discuss its possible role in health and disease. Their review complements other recent reviews of this subject, such as that by Dostal and Baker.2 Uniquely, however, the present review discusses the potential role of intracellular angiotensin II, called intracrine angiotensin II, in intercellular signaling and calcium flux in the heart. These findings are based on De Mello’s studies1 of renin, angiotensin I, and angiotensin II dialyzed into rat cardiac cells. The evidence for the influence of an intracellular AT1-like angiotensin II receptor on intercellular communication is compelling and supports the concept of an intracrine angiotensin II system in the heart, with possible implications for cardiac conduction and contractility in health and disease. Also, the review emphasizes the potential importance of the uptake of prorenin by cells and its subsequent activation in the intracellular milieu, as demonstrated by De Mello and Danser.1 However, a more complete discussion of the role of locally synthesized renin must be found elsewhere.2 In this regard, it can be noted that once the possibility of intracellular angiotensin action is accepted, quantitative arguments discounting the importance of local synthesis of renin or angiotensinogen become less compelling, in that effective intracellular concentrations of hormone can be achieved even if only small quantities of protein are produced.The concept of intracellular peptide hormone action, ie, intracrine action, remains foreign to most. Our laboratory introduced the term intracrine on the basis of extensive studies of the intracellular actions of angiotensin II, including its interactions with specific nuclear receptors to regulate gene transcription.3 The term intracrine was applied to the actions of hormones synthesized intracellularly as well as to the intracellular actions of hormone internalized from the extracellular space. In the case of angiotensin II, a small but growing body of evidence has developed to indicate that angiotensin II does indeed bind to intracellular receptors with effects on the transcriptional regulation of renin and angiotensinogen and with effects on calcium ion fluxes.45 The latter findings parallel those previously reported by De Mello and Danser1 involving intracellular calcium currents and intercellular communication in the heart. Also possibly related is the observation that some effects of angiotensin on sodium transport by renal tubular cells appear to require hormone internalization.6 Thus, evidence is emerging to indicate that angiotensin II can perform a variety of physiologically relevant intracrine actions, including influencing cardiac conduction and contractility.Do other intracrine systems exist? Over the last 20 years, evidence has accumulated to indicate that many, and perhaps all, peptide growth factors and hormones operate in part through an intracellular mode of action. Included among these growth factors, hormones, and proteins are the following: insulin, fibroblast growth factor (FGF) A and FGF B (FGF-1 and FGF-2, respectively), platelet-derived growth factor, nerve growth factor, epidermal growth factor, growth hormone, prolactin, parathyroid hormone–related protein, angiogenin, tat protein, interferon-γ, hepatoma-derived growth factor, and a wide variety of other protein hormones.37891011 Of note is the fact that in some cases (eg, parathyroid hormone–related protein and FGF-2), relatively large amounts of peptide hormone can be demonstrated in association with intracellular organelles such as the nucleus. In some cases, nucleolar binding is noted. In some cases, intracellular hormone appears to be associated with specific high-affinity receptors (eg, angiotensin II), whereas in other cases (eg, FGF-2), lower specificity binding is found. Finally, intracrine hormone can be synthesized in situ or act after internalization. Thus, intracrine function is complex and poorly understood.Are there any principles of intracrine peptide hormone action? The existence of intracellular regulatory peptide factors influencing gene transcription or other intracellular functions is well established. Indeed, intracellular peptide feedback loops have been associated with the regulation of cellular processes such as the establishment of biological rhythms.12 If intracellular peptide hormones can similarly form feedback loops, might they not play a role in such processes as cellular differentiation and memory?3 The answer to this question will have to await further experimentation. However, there are even now observations that may bear on this issue. For example, it has been reported that the treatment of spontaneously hypertensive rats early in life with a converting enzyme inhibitor produces a long-lasting normalization of blood pressure and long-lasting effects on angiotensin receptor number in specific cells.13 A similar phenomenon has been reported after AT1 antisense therapy.14 How is this effect produced? Clearly, a long-lived change has been produced in these animals at either the tissue or cellular level, and among the possible explanations is the idea that the interruption of intracrine systems could play a role; ie, if intracrine angiotensin II stimulates the cellular production and secretion of angiotensin II with a resulting upregulation of intracrine angiotensin II in nearby target cells, the interruption of this process with a converting enzyme inhibitor could lead to long-lasting downregulation of tissue angiotensin. Other forms of angiotensin-induced memory could result from a similar mechanism.15 Likewise, the apparent amplification of physiological effects that is associated with some forms of gene therapy could be due to the upregulation of similar intracrine hormone systems, with resulting stimulation of nearby cells to operate at a higher level of activity.1516 In this process, the intracrine pool of hormone would serve as a reservoir to maintain hormone action in the face of short-term variations in ambient extracellular concentrations of hormone. Thus, the introduction of genes for vascular endothelial growth factor (VEGF) in relatively few cells could, through an intracrine action in those cells, stimulate the enhanced secretion of VEGF, which (after internalization) upregulates intracrine VEGF in surrounding cells, thereby producing a wave of long-lived VEGF production and, ultimately, the formation of new vessels.These latter mechanisms must remain conjecture, but the review of De Mello and Danser1 clearly marks a step forward in the ultimate elucidation of intracrine action and its role in biology and medicine. Their review should also stimulate new investigation into the effects of angiotensin on cardiac conduction and contractility in health and disease.The opinions expressed in this editorial are not necessarily those of the editors or of the American Heart Association.FootnotesCorrespondence to Richard N. Re, Alton Oschner Medical Foundation, 1516 Jefferson Hwy, BH 511, New Orleans, LA 70121-2484. References 1 De Mello WC, Danser AHJ. Angiotensin II and the heart: on the intracrine renin-angiotensin system. Hypertension..2000; 35:1183–1188.CrossrefMedlineGoogle Scholar2 Dostal DE, Baker KM. The cardiac renin-angiotensin system: conceptual, or a regulator of cardiac function? Circ Res.1999; 85:643–650.CrossrefMedlineGoogle Scholar3 Re RN. The nature of intracrine peptide hormone action. Hypertension.1999; 34:534–538.CrossrefMedlineGoogle Scholar4 Eggena P, Zhu JH, Clegg K, Barrett JD. Nuclear angiotensin receptors induce transcription of renin and angiotensinogen in RNA. Hypertension.1993; 22:496–501.LinkGoogle Scholar5 Haller H, Lindschau C, Quass P, Luft FC. Intracellular actions of angiotensin II in vascular smooth muscle cells. J Am Soc Nephrol. 1999;10(suppl 11):S75–S83.Google Scholar6 Becker BN, Harris RC. A potential mechanism for proximal tubule angiotensin II-mediated sodium flux associated with receptor-mediated endocytosis and arachidonic acid release. Kidney Int Suppl..1996; 57:S66–S72.MedlineGoogle Scholar7 Goldfine ID, Smith GJ, Yong KY, Jones AL. Cellular uptake and nuclear binding of insulin in human cultured lymphocytes: evidence for potential intracellular sites of insulin action. Proc Natl Acad Sci U S A.1977; 74:1368–1372.CrossrefMedlineGoogle Scholar8 Bouche G, Gus N, Prats H, Baldin V, Tauber JP, Teissie J, Amalric F. Basic fibroblast growth factor enters the nucleolus and stimulates the transcription of ribosomal genes in ABAE cells undergoing G0-G1 transition. Proc Natl Acad Sci U S A.1987; 84:6770–6774.CrossrefMedlineGoogle Scholar9 Rakowicz-Szulczynska EM, Rodeck U, Herlyn M, Koprowski H. Chromatin binding of epidermal growth factor, nerve growth factor and platelet derived growth factor in cells bearing appropriate surface receptors. Proc Natl Acad Sci U S A.1986; 83:3728–3732.CrossrefMedlineGoogle Scholar10 Delrieu I. The high molecular weight isoforms of basic fibroblast growth factor (FGF-2): an insight into an intracrine mechanism. FEBS Lett..2000; 468:6–10.CrossrefMedlineGoogle Scholar11 Everett AD, Lobe DR, Mâtsumura ME, Nakamura H, McNamara CA. Hepatoma-derived growth factor stimulates smooth muscle cell growth and is expressed in vascular development. J Clin Invest..2000; 105:567–575.CrossrefMedlineGoogle Scholar12 Kume K, Zylka MJ, Sriram S, Sheraman LP, Weaver DR, Jin X, Maywood ES, Hastings MH, Reppert SM. mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell.1999; 98:193–205.CrossrefMedlineGoogle Scholar13 Berecek KH, Swords BH, Low S, Kirk KA. Effect of angiotensin converting enzyme inhibitor upon brain angiotensin II binding. J Hypertens..1992; 10:545–552.CrossrefMedlineGoogle Scholar14 Martiens JR, Reavis PY, Lu D, Katovich MJ, Bereck KH, Bishop S, Raizda MK, Gelband CH. Prevention of renovascular and cardiac pathophysiological changes in hypertension by angiotensin II type 1 receptor antisense gene therapy. Proc Natl Acad Sci U S A.1998; 95:2664–2669.CrossrefMedlineGoogle Scholar15 Richard T, Danilo P, Jr, Cohen IS, Burkhoff D, Rosen MR. A role for the renin-angiotensin system in the evolution of cardiac memory. J Cardiovasc Electrophysiol.1999; 10:545–551.CrossrefMedlineGoogle Scholar16 Isner J, Asahara T. Angiogenesis and vasculogenesis as therapeutic strategies for post-natal neovascularization. J Clin Invest.1999; 103:1231–1236CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetailsCited By C. Li X, Paula de Oliveira Leite A, Chen X, Zhao C, Zheng X, Zhang J and L. Zhuo J (2020) The Intratubular and Intracrine Renin-Angiotensin System in the Proximal Tubules of the Kidney and Its Roles in Angiotensin II-Induced Hypertension Selected Chapters from the Renin-Angiotensin System, 10.5772/intechopen.88054 Li X and Zhuo J (2015) The Renin-Angiotensin System and the Kidney: New Insights and Perspectives , Colloquium Series on Integrated Systems Physiology: From Molecule to Function, 10.4199/C00124ED1V01Y201501ISP059, 7:1, (1-61), Online publication date: 18-Mar-2015. Zhang D, Liu J, Zheng H, Tu H, Muelleman R and Li Y (2015) Effect of angiotensin II on voltage-gated sodium currents in aortic baroreceptor neurons and arterial baroreflex sensitivity in heart failure rats, Journal of Hypertension, 10.1097/HJH.0000000000000563, 33:7, (1401-1410), Online publication date: 1-Jul-2015. Rukavina Mikusic N, Kravetz M, Kouyoumdzian N, Della Penna S, Rosón M, Fernández B and Choi M (2014) Signaling Pathways Involved in Renal Oxidative Injury: Role of the Vasoactive Peptides and the Renal Dopaminergic System, Journal of Signal Transduction, 10.1155/2014/731350, 2014, (1-15), Online publication date: 11-Nov-2014. Cook J and Re R (2012) Review: Lessons from in vitro studies and a related intracellular angiotensin II transgenic mouse model , American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 10.1152/ajpregu.00493.2011, 302:5, (R482-R493), Online publication date: 1-Mar-2012. Ellis B, Li X, Miguel-Qin E, Gu V and Zhuo J (2012) Review: Evidence for a functional intracellular angiotensin system in the proximal tubule of the kidney , American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 10.1152/ajpregu.00487.2011, 302:5, (R494-R509), Online publication date: 1-Mar-2012. Li X, Cook J, Rubera I, Tauc M, Zhang F and Zhuo J (2011) Intrarenal transfer of an intracellular fluorescent fusion of angiotensin II selectively in proximal tubules increases blood pressure in rats and mice, American Journal of Physiology-Renal Physiology, 10.1152/ajprenal.00329.2010, 300:5, (F1076-F1088), Online publication date: 1-May-2011. Zhuo J and Li X (2011) New insights and perspectives on intrarenal renin-angiotensin system: Focus on intracrine/intracellular angiotensin II, Peptides, 10.1016/j.peptides.2011.05.012, 32:7, (1551-1565), Online publication date: 1-Jul-2011. Salgado D, Rocco J, Silva E and Vincent J (2009) Modulation of the renin–angiotensin–aldosterone system in sepsis: a new therapeutic approach?, Expert Opinion on Therapeutic Targets, 10.1517/14728220903460332, 14:1, (11-20), Online publication date: 1-Jan-2010. DeMello W and Re R (2009) Systemic Versus Local Renin Angiotensin Systems. 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