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• W2155111496 abstract "Introduction: Dyspnea is the most common and distressing symptoms in heart failure (HF) patients. The development of effective symptom management interventions necessitates the identification of the effect of dyspnea symptom trends on disease outcomes in HF patients. Specific Aims: To determine the relationship of trends in dyspnea (measured 3 times over 12 months) on HF patients' outcomes (i.e., mortality, emergency room visits, and hospitalization). Method: In this longitudinal study we determined the association of individual symptom trajectory on outcome in chronic HF patients. Dyspnea, clinical characteristics, and outcomes were measured at the baseline, three months, and 12 months later. Disease outcomes were measured by monthly phone interviews. This study uses a latent class growth model to examine the functional trajectories. Individuals were classified into 3 subgroups based on their dyspnea intensity at the baseline, after 3 months, and after 12 months. This classification reflected dyspnea trajectory over three time points. Kaplan-Meier survival analysis revealed the 12-month follow-up disease outcomes. Results: One hundred and seventeen HF patients were recruited (mean age 62.8 ± 13.0 yrs; 79% male; 39% NYHA III/IV). The first group (n = 90), labeled “constant good,” was characterized by a good dyspnea status at the baseline that remained stable in 12 months (B = -0.00765). The second group (n = 20), labeled “recovery,” was characterized by a poor dyspnea status at the baseline with a significantly positive linear slope (B = 0.38722). The third group (n = 7), labeled “getting worse,” was characterized by a good dyspnea status at the baseline with a significantly negative linear slope (B = −0.18087). The cumulative incidence of first event in HF patients who demonstrated a “getting worse” dyspnea trajectory was significantly higher than that in patients who demonstrated a “constant good” and “recovery” dyspnea trajectory (log-rank test, p-value = 0.046). Conclusion: Trends in dyspnea are better predictors to HF outcomes than one time assessment. Long-term physical symptom monitoring and attention can benefit to HF patients." @default.
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• W2155111496 date "2010-08-01" @default.
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• W2155111496 title "Trends in Dyspnea Predict 12-Month Outcomes in Patients With Heart Failure" @default.
• W2155111496 doi "https://doi.org/10.1016/j.cardfail.2010.06.016" @default.
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