Matches in SemOpenAlex for { <https://semopenalex.org/work/W2155111953> ?p ?o ?g. }
- W2155111953 endingPage "131" @default.
- W2155111953 startingPage "121" @default.
- W2155111953 abstract "Administration of mesenchymal stem cells (MSCs) that have a reliable potential for chondrogenic differentiation is a promising approach currently employed to treat articular cartilage lesions (focal defects and osteoarthritis) in patients as a mean to enhance the poor intrinsic capabilities of this specialized tissue for self-repair. However, there is still a critical need for improved designs, as reproduction of a native structural and functional unit in sites of cartilage damage is not occurring upon implantation of such cells. With the availability of optimized gene transfer systems, gene therapy offers powerful tools to stimulate the chondrogenic process in MSCs via the effective, safe, and durable delivery of candidate sequences with chondroprotective and/or chondroregenerative properties, both in vitro and in experimental models of cartilage lesions in vivo. In the present article, we provide an overview of the current advances in gene- and stem cell-based treatments employed to promote cartilage repair in focal defects and for osteoarthritis, and discuss the challenges that remain to be addressed for a safe translation of such procedures into the clinics." @default.
- W2155111953 created "2016-06-24" @default.
- W2155111953 creator A5026715836 @default.
- W2155111953 creator A5028522969 @default.
- W2155111953 creator A5056594389 @default.
- W2155111953 creator A5083556223 @default.
- W2155111953 creator A5083684200 @default.
- W2155111953 date "2015-01-14" @default.
- W2155111953 modified "2023-10-10" @default.
- W2155111953 title "Current Progress in Stem Cell-Based Gene Therapy for Articular Cartilage Repair" @default.
- W2155111953 cites W14481853 @default.
- W2155111953 cites W14996649 @default.
- W2155111953 cites W1509278025 @default.
- W2155111953 cites W1522229466 @default.
- W2155111953 cites W1530066186 @default.
- W2155111953 cites W1572233670 @default.
- W2155111953 cites W1606976518 @default.
- W2155111953 cites W1648831305 @default.
- W2155111953 cites W1803306759 @default.
- W2155111953 cites W1859919406 @default.
- W2155111953 cites W1892871548 @default.
- W2155111953 cites W1939632735 @default.
- W2155111953 cites W1962540378 @default.
- W2155111953 cites W1964352781 @default.
- W2155111953 cites W1964467175 @default.
- W2155111953 cites W1965165277 @default.
- W2155111953 cites W1965380417 @default.
- W2155111953 cites W1965387344 @default.
- W2155111953 cites W1965665343 @default.
- W2155111953 cites W1967269017 @default.
- W2155111953 cites W1967474304 @default.
- W2155111953 cites W1968746947 @default.
- W2155111953 cites W1969646755 @default.
- W2155111953 cites W1969834555 @default.
- W2155111953 cites W1970043108 @default.
- W2155111953 cites W1970643731 @default.
- W2155111953 cites W1973037878 @default.
- W2155111953 cites W1973950443 @default.
- W2155111953 cites W1974196968 @default.
- W2155111953 cites W1974870421 @default.
- W2155111953 cites W1976960856 @default.
- W2155111953 cites W1979738387 @default.
- W2155111953 cites W1984095256 @default.
- W2155111953 cites W1988592246 @default.
- W2155111953 cites W1990226086 @default.
- W2155111953 cites W1991028558 @default.
- W2155111953 cites W1991415492 @default.
- W2155111953 cites W1993355100 @default.
- W2155111953 cites W1994609162 @default.
- W2155111953 cites W1995122819 @default.
- W2155111953 cites W1996315523 @default.
- W2155111953 cites W1999013968 @default.
- W2155111953 cites W1999775304 @default.
- W2155111953 cites W2000097208 @default.
- W2155111953 cites W2002522628 @default.
- W2155111953 cites W2002791185 @default.
- W2155111953 cites W2004247546 @default.
- W2155111953 cites W2004471754 @default.
- W2155111953 cites W2004724795 @default.
- W2155111953 cites W2006437934 @default.
- W2155111953 cites W2006797212 @default.
- W2155111953 cites W2014486018 @default.
- W2155111953 cites W2014684686 @default.
- W2155111953 cites W2018648995 @default.
- W2155111953 cites W2019082902 @default.
- W2155111953 cites W2021222096 @default.
- W2155111953 cites W2024323703 @default.
- W2155111953 cites W2024835620 @default.
- W2155111953 cites W2025371271 @default.
- W2155111953 cites W2025589108 @default.
- W2155111953 cites W2026734181 @default.
- W2155111953 cites W2027779389 @default.
- W2155111953 cites W2028046200 @default.
- W2155111953 cites W2028212402 @default.
- W2155111953 cites W2032282401 @default.
- W2155111953 cites W2035395313 @default.
- W2155111953 cites W2035741764 @default.
- W2155111953 cites W2036280386 @default.
- W2155111953 cites W2038052982 @default.
- W2155111953 cites W2038071953 @default.
- W2155111953 cites W2039488563 @default.
- W2155111953 cites W2044185280 @default.
- W2155111953 cites W2045289830 @default.
- W2155111953 cites W2048962178 @default.
- W2155111953 cites W2051531880 @default.
- W2155111953 cites W2052356779 @default.
- W2155111953 cites W2052853106 @default.
- W2155111953 cites W2054957214 @default.
- W2155111953 cites W2055431807 @default.
- W2155111953 cites W2056510698 @default.
- W2155111953 cites W2057315313 @default.
- W2155111953 cites W2057886697 @default.
- W2155111953 cites W2061035981 @default.
- W2155111953 cites W2062183994 @default.
- W2155111953 cites W2062253021 @default.
- W2155111953 cites W2063795648 @default.
- W2155111953 cites W2064274538 @default.
- W2155111953 cites W2065154652 @default.